Crohn’s Disease of the Upper Gastrointestinal Tract

Haggitt, Rodger C.; Meissner, William A.

doi:10.1093/ajcp/59.5.613

Cited by 76 publications

(37 citation statements)

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“…The regional esophagitis in 12 of the previously reported cases was associated with Crohn's disease of the small bowel, colon, or both [1,4,8,9,[11][12][13][14]17]. Similarly, our 2 patients had pathologically proven granulomatous ileocolitis, and a third site of involvement in the gastric antrum was noted during barium studies and laparotomy in case 2.…”

Section: Discussionsupporting

confidence: 56%

“…D Barium enema examination shows the diffusely nodular mucosa of the colon with lack of haustral markings. The narrowed terminal ileum and sigmoid are displaced by the extrinsic pressure of inflamed ileal loops occupying the right lower abdomen ever, the esophageal involvement by Crohn's disease represents a rarity [1,4,[7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Casementioning

confidence: 99%

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Esophageal manifestations of Crohn's disease

Ghahremani

Gore

Breuer

et al. 1982

Gastrointest Radiol

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Two patients with concurrent esophagitis and ileocolitis due to Crohn's disease are presented. The initial feature of esophageal involvement was dysphagia caused by severe inflammation of the distal esophagus with mucosal ulcerations and polypoid folds. Long-term observation of both cases revealed a gradually progressive course leading to development of rigid esophageal structure, intramural sinus tract, and esophagobronchial or esophagogastric fistulas. The clinical and radiographic manifestations of Crohn's esophagitis in these 2 patients and in 18 previously reported cases are reviewed.

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Section: Discussionsupporting

confidence: 56%

Section: Casementioning

confidence: 99%

Esophageal manifestations of Crohn's disease

Ghahremani

Gore

Breuer

et al. 1982

Gastrointest Radiol

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“…The noncaseating granuloma is generally accepted as histologic proof of Crohn's disease, provided that other causes of granulomatous involvement of the gastrointestinal tract can be excluded [2]. It is, however, extremely rare to find a granuloma in endoscopic biopsies.…”

Section: Discussionmentioning

confidence: 99%

Crohn's disease of the esophagus

et al. 1989

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Esophageal involvement in patients with Crohn's disease is uncommon. Histologic proof is rarely obtained by means of endoscopic biopsies. Moreover, the natural history of this condition and its response to therapy are largely unknown. We report a case of biopsy-proven esophageal Crohn's disease, which presented with a stricture of the distal third of the esophagus and was successfully treated by progressive endoscopic dilatation.

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“…In contrast, Crohn’s disease (CD) has been identified in all parts of the gastrointestinal tract, from the mouth to the anus [1]. The involvement of the upper gastrointestinal tract in IBD is generally considered characteristic of CD [2,3,4,5,6], and the demonstration of typical CD lesions (granulomas and multinucleated giant cells) in surgical specimens or biopsy samples taken at upper endoscopy clearly differentiates patients with CD from those with other forms of idiopathic IBD [7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

Immunological Status of the Stomach in Inflammatory Bowel Disease – Comparison between Ulcerative Colitis and Crohn’s Disease

Ando¹,

Watanabe²,

Nobata³

et al. 2008

Digestion

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Background/Aims: Ulcerative colitis (UC) mainly affects the colon and rectum, whereas the chronic inflammatory process in Crohn’s disease (CD) can affect any part of the gastrointestinal tract. Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients. Methods: 26 patients each with UC, CD or functional dyspepsia (FD) underwent diagnostic upper gastrointestinal endoscopy, and biopsy specimens were obtained from the gastric antrum.The contents of interleukin (IL)-6 and IL-8 in the organ culture supernatants of antral mucosal tissues were measured with enzyme-linked immunosorbent assay. Results: Endoscopically abnormal findings in the stomach were more frequent in CD than in UC or FD patients. Mononuclear cell infiltration and IL-6 production in the gastric antrum did not significantly differ between UC and FD patients, but were higher in those with CD. There was no significant difference in neutrophil infiltration or IL-8 production between UC, CD, and FD patients. Conclusions: UC patients did not show the immunological abnormalities in the stomach seen in CD patients.

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Crohn’s Disease of the Upper Gastrointestinal Tract

Cited by 76 publications

References 0 publications

Esophageal manifestations of Crohn's disease

Esophageal manifestations of Crohn's disease

Crohn's disease of the esophagus

Immunological Status of the Stomach in Inflammatory Bowel Disease – Comparison between Ulcerative Colitis and Crohn’s Disease

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