Crohn's disease of the colon.

McGovern, V. J.; Goulston, S. J. M.

doi:10.1136/gut.9.2.164

Cited by 114 publications

(17 citation statements)

References 11 publications

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“…However, we did not find any significant difference in the recurrence rate whether or not the ileum was involved at the time of excisional surgery, nor can we support the contention of McGovern and Goulston (1968) that granulomatous colitis with involvement of the terminal ileum behaves in a more benign manner than if the disease is confined to the colon. De Dombal et al (1971) suggest that the younger the patient at the time of the first operation the greater the risk of recurrence and our results support this suggestion.…”

Section: Discussioncontrasting

confidence: 53%

Excisional surgery with ileostomy for Crohn's colitis with particular reference to factors affecting recurrence

Steinberg¹,

Allan²,

Thompson³

et al. 1974

Gut

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SUMMARY This paper reports the indications for, and results of, excision of the large intestine with ileostomy in 73 patients with Crohn's colitis who have been followed for a mean of nine years since resection. Sixty-four of them are still alive and all but two of the survivors are now in good health.However, 23 (33 %) have developed recurrent Crohn's disease since resection. This is higher than that reported in many other series and may be due to differences in the length of follow up, the site and extent of colonic disease, the age of the patient at the time of excision with ileostomy, and differences in the pathological interpretation of the diagnosis of Crohn's disease. The high recurrence rate in this series lends caution to the view that the prognosis after excisional surgery and ileostomy for Crohn's colitis is as good as after the same operation for ulcerative colitis and should influence the decision when the alternative of medical or surgical management are being considered for patients with Crohn's colitis.

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Section: Discussioncontrasting

confidence: 53%

Excisional surgery with ileostomy for Crohn's colitis with particular reference to factors affecting recurrence

Steinberg¹,

Allan²,

Thompson³

et al. 1974

Gut

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“…Williams (1964) as well as McGovern and Goulston (1968) observed obstructive vasculitis only occasionally. According to Knutson et al (1968), intimal and medial hyperplastic with narrowing of arterial lumina is a common and significant finding in Crohn's disease.…”

Section: Commentsmentioning

confidence: 93%

A comparative radiographic and pathological study of intestinal vaso-architecture in Crohn's disease and in ulcerative colitis

Brahme¹,

Lindström²

1970

Gut

117

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“…Crohn's disease affects the large intestine much less frequently than it affects the terminal ileum and other parts of the small intestine. Crohn's disease of the colon involves most of the large intestine, even all of it, or it may occur in the form of single or multiple strictures (32,39). Rarely is it confined to the rectum.…”

Section: Crohn's Diseasementioning

confidence: 99%

Colon Diseases in Recent Years in Japan: From the Viewpoint of a Pathologist

Irie

1999

Bioscience Microflora

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As the cause of one disease becomes clear and specific therapies for it are established, other diseases formerly of lesser importance become serious problems. Ulcerative colitis and Crohn's disease, which were unfamiliar diseases in Japan about 20 years ago, are on the increase. The cause remains unclear, but the tendency seems to be closely related to changes in Japanese lifestyle, especially to changes in diet, which has become more similar to the Euro-American diet. Part 1 of this paper outlines the recent development of colonic inflammatory diseases in Japan as seen by the pathologist. The endoscope has enabled remarkable clinical progress, and colonoscopic examinations are performed readily in most patients who complain of intestinal problems. There are many opportunities to detect polyps of the colon, and such polyps rank with inflammatory bowel diseases. The adenoma-carcinoma sequence theory was proposed by Morson in 1968, but most adenomas do not generate cancer over the long term, and the wide utilization of polypectomy has not decreased the colon cancer rate. There is some doubt as to whether all colon cancers develop from adenoma. In recent years, practitioners have discovered very small elevated, flat or depressed colon carcinomas that have no polyp (adenoma) component. There are known as de novo cancers. However, neither the adenoma-carcinoma sequence nor de novo cancer give a complete account for the carcinogenesis of colon cancer yet. Part 2 of this paper explores the pathohistological relation between adenoma and carcinoma.

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Crohn's disease of the colon.

Cited by 114 publications

References 11 publications

Excisional surgery with ileostomy for Crohn's colitis with particular reference to factors affecting recurrence

Excisional surgery with ileostomy for Crohn's colitis with particular reference to factors affecting recurrence

A comparative radiographic and pathological study of intestinal vaso-architecture in Crohn's disease and in ulcerative colitis

Colon Diseases in Recent Years in Japan: From the Viewpoint of a Pathologist

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