Crohn's disease lymphadenopathy: MR imaging findings

Gourtsoyianni, Sofia; Papanikolaou, Nikolaos; Amanakis, Emmanouil; Bourikas, Leonidas A.; Roussomoustakaki, Maria; Grammatikakis, John; Gourtsoyiannis, Nicholas

doi:10.1016/j.ejrad.2008.11.009

Cited by 41 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature search revealed 2501 abstracts related to MRI use in CD. Of these, 244 were retrieved and 62 studies were deemed appropriate for inclusion (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: magnetic resonance enterography signs for the detection of inflammation and intestinal damage in Crohn's disease

Church

Turner

Feldman

et al. 2014

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Summary Background In the treatment of Crohn's disease (CD), mucosal healing has become a major goal, with the hope of avoiding intestinal damage from chronic inflammation. Magnetic resonance enterography (MRE) has emerged as a non‐invasive means of monitoring inflammation and damage. Aims As part of the development of MRE‐based multi‐item measures of inflammation and damage for paediatric studies, we carried out a systematic review and meta‐analysis to identify MRE variables used to describe these two distinct concepts. Methods 2501 studies of MRI and CD were identified. Studies written in any language reporting individual MRE signs for patients diagnosed with CD were included. Two‐hundred‐and‐forty‐four studies were fully reviewed and 62 were included (inflammation, n = 51; damage, n = 24). Sensitivity, specificity and associated confidence intervals were calculated, and hierarchical summary ROC curves were constructed for each MRE sign. Results A total of 22 MRE signs were used to reflect inflammation, and 9 to reflect damage. Diagnostic accuracy of MRE signs of inflammation and damage was heterogeneous; however, wall enhancement, mucosal lesions and wall T2 hyperintensity were the most consistently useful for inflammation (most sensitivities >80% and specificities >90%), and detection of abscess and fistula were most consistently useful for damage (most sensitivities >90%, specificities >95%). Conclusions Identifying the best MRE variables to reflect inflammation and damage will maximise the utility of this rapidly emerging technique and is the first stage of constructing MRE‐based indices for evaluating inflammation and intestinal damage.

show abstract

“…The literature search revealed 2501 abstracts related to MRI use in CD. Of these, 244 were retrieved and 62 studies were deemed appropriate for inclusion (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: magnetic resonance enterography signs for the detection of inflammation and intestinal damage in Crohn's disease

Church

Turner

Feldman

et al. 2014

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Associated extraluminal findings indicating active inflammation include mesenteric hyperemia, reactive mesenteric lymphadenopathy, and inflammation of mesenteric fat [ 39 46 47 ]. The engorgement of mesenteric vascular structures, known as the comb sign, is depicted well on fat-saturated T2- and postcontrast T1-weighted sequences ( Fig.…”

Section: Interpretation Of Imaging Findingsmentioning

confidence: 99%

Pediatric Magnetic Resonance Enterography: Focused on Crohn's Disease

Lee

Kim

Choi

2015

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Crohn's disease is a chronic idiopathic inflammatory disease of the intestines characterized by frequent relapse and remission. It often develops in children and adolescents, who are vulnerable to repeated exposure to ionizing radiations. Magnetic resonance enterography (MRE) is an increasingly important radiation-free imaging modality that is used to evaluate pediatric patients with Crohn's disease. MRE can evaluate extraluminal and extraintestinal abnormalities as well as the status of the bowel wall. In addition, MRE has an advantage in the evaluation of the small bowel involvement. MRE can be used for the initial diagnosis of Crohn's disease, and can aid in the assessment of disease activity and complications such as penetrating and fibrostenotic diseases. The aims of this article are to review the MRE technique for obtaining diagnostic and high-quality images and to discuss interpretations of imaging findings in patients with Crohn's disease.

show abstract

“…8,9,22 Complications such as enteroenteric, enterovisceral, and enterocutaneous fistulas reflecting the extensive destruction of the digestive tract in CD can also be detected by MRE. 8,9 However, it should be mentioned that according to the more recent data, a dynamic assessment of CD activity in MRE might be superior to a static evaluation.…”

Section: Patients With Isolated Small-bowel Crohn's Diseasementioning

confidence: 99%