Crohn's disease is associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene

Negoro, Kenichi; Kinouchi, Yoshitaka; Hiwatashi, Nobuo; Takahashi, Seiichi; Takagi, Sho; Satoh, Jo; Shimosegawa, Tooru; Toyota, Takayoshi

doi:10.1016/s0016-5085(99)70390-2

Cited by 172 publications

(144 citation statements)

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“…CARD15 was found to be associated with IBD by means of genome-wide sib-pair (Hampe et al 2001;Hugot et al 2001;Ogura et al 2001). Through the candidate gene approach, various genes, such as mucin 3 (MUC3), tumor necrosis factor (TNF), and HLA class II, were identified as candidate genes susceptible to IBD in some populations (Nakajima et al 1995;Kyo et al 1999Kyo et al , 2001Negoro et al 1999). In addition, recent studies identified three candidate susceptibility genes at two loci, one was SLC22A4 and SLC22A5 on chromosome 5 corresponding to IBD5 (Peltekova et al 2004), and the other was DLG5 on chromosome 10 (Stoll et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease

et al. 2004

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Crohn disease (CD) is an inflammatory bowel disease characterized by chronic transmural, segmental, and typically granulomatous inflammation of the gut. Recently, two novel candidate gene loci associated with CD, SLC22A4 and SLC22A5 on chromosome 5 known as IBD5 and DLG5 on chromosome 10, were identified through association analysis of Caucasian CD patients. We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023). However, the reported genetic variants that were indicated to be causative in the Caucasian population were completely absent in or were not associated with Japanese CD patients. These findings imply significant differences in genetic background with CD susceptibility among different ethnic groups and further indicate some difficulty of population-based studies.Keywords Crohn disease AE Single-nucleotide polymorphism (SNP) AE DLG5 AE SLC22A4 AE SLC22A5 AE OCTN1 AE OCTN2 AE Japanese population

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Section: Discussionmentioning

confidence: 99%

Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease

et al. 2004

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“…This study also found À863A to be associated with HCV clearance. 13 The TNF gene has been examined in many other diseases, and À863A has been associated with diseases related to increased immune activation including Crohn's disease 19 and human T-cell lymphotrophic virus-1 uveitis. 20 Other studies of HCV have not noted this association, but most were small and did not examine the SNP at À863.…”

Section: Discussionmentioning

confidence: 99%

An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection

et al. 2004

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The cytokine tumor necrosis factor alpha (TNF-a) is important in generating an immune response against a hepatitis C virus (HCV) infection. The functions of TNF-a may be altered by single-nucleotide polymorphisms (SNPs) in its gene, TNF. We hypothesized that SNPs in TNF may be important in determining the outcome of an HCV infection. To test this hypothesis, we typed nine TNF SNPs in a cohort of individuals with well-defined HCV outcomes. Three of these SNPs were typed in a second cohort. Data were analyzed using logistic regression stratifying by ethnicity, since rates of HCV clearance differ in black subjects versus white subjects. The SNP À863A was associated with viral clearance in black subjects (odds ratios (OR) 0.52, 95% confidence interval (CI) 0.29-0.93). Furthermore, the common wild-type haplotype À863C/À308G was associated with viral persistence in black subjects (OR 1.91, 95% CI 1.24-2.95). These findings were independent of linkage with human leukocyte antigen (HLA) alleles. Further study of this polymorphism and haplotype is needed to understand these associations and the role of TNF-a in determining outcomes of HCV infection.

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“…These alleles have been associated with juvenile rheumatoid arthritis (Date et al 1999) and Crohn's disease (Negoro et al 1999) among the Japanese. However, there are no reports indicationg an association of these polymorphisms with metabolic syndrome or atherosclerosis.…”

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Association of TNF-.ALPHA. Gene Promoter C-857T Polymorphism with Higher Serum LDL Cholesterol Levels and Carotid Plaque Formation in Japanese Patients with Type 2 Diabetes

Yamashina

Kaneko

Maesawa

et al. 2007

Tohoku J. Exp. Med.

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Crohn's disease is associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene

Cited by 172 publications

References 34 publications

Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease

Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease

An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection

Association of TNF-.ALPHA. Gene Promoter C-857T Polymorphism with Higher Serum LDL Cholesterol Levels and Carotid Plaque Formation in Japanese Patients with Type 2 Diabetes

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