Crohn's disease: Influence of age at diagnosis on site and clinical type of disease

Polito, JM; Childs, Barton; Ed, Mellits; Tokayer, AZ; Harris, Mark; Bayless, TM

doi:10.1053/gast.1996.v111.pm8780560

Cited by 311 publications

(227 citation statements)

References 4 publications

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“…This is remarkably less than what was found by some authors, 20,22,23 but similar to recent reports, particularly the multicenter European study. 10 In this study a cumulative relapse rate of 57% (53%-61%) at 5 years and 67% (63%-71%) at 10 years were reported. These data indicate that there is a large proportion of patients with a disease course characterized by a decrease in symptoms during the follow-up period, in accordance with the patient's perception of their disease as described in the IBSEN study.…”

mentioning

confidence: 55%

“…In CD there is clear evidence showing that early-onset represents a distinct and more aggressive phenotype, 10 with greater need for surgery; however, in relation to UC the data are scarce. In this cross-sectional study, by applying the same stratification for the variable age at disease onset as the Montreal Classification for CD, younger patients seem to have a more aggressive initial course, with a higher rate of extraintestinal manifestations, pancolitis, and the need for steroids and immunomodulators.…”

Section: Discussionmentioning

confidence: 99%

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Ulcerative colitis in a Southern European country: A national perspective

Portela

Magro²,

Lago³

et al. 2010

Inflammatory Bowel Diseases

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mentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Ulcerative colitis in a Southern European country: A national perspective

Portela

Magro²,

Lago³

et al. 2010

Inflammatory Bowel Diseases

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“…The variable age at diagnosis, that is proper to assess time-dependent consequences of CD, in several studies has been related to disease location, gender, and familial history (10,18,21) . In 1996, Polito et al (21) , analyzing a cohort of 552 consecutive patients, found that a lesser age at diagnosis was associated with higher rates of familial history of CD, small bowel onset, stricturing disease, and surgery; younger age at diagnosis was also correlated with genetic factors (12) .…”

Section: Discussionmentioning

confidence: 99%

“…In 1996, Polito et al (21) , analyzing a cohort of 552 consecutive patients, found that a lesser age at diagnosis was associated with higher rates of familial history of CD, small bowel onset, stricturing disease, and surgery; younger age at diagnosis was also correlated with genetic factors (12) . Therefore, by adding a more refined pediatric category to this variable, MC allowed that future studies could confirm the age effects on diagnosis about the behavior of CD.…”

Section: Discussionmentioning

confidence: 99%

The Montreal classification for Crohn's disease: clinical application to a Brazilian single-center cohort of 90 consecutive patients

Torres

Rodrigues

Junqueira

et al. 2010

Arq. Gastroenterol.

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CONTEXT: Crohn's disease presents very heterogeneous features from a clinical point of view, and classifying Crohn's disease patients in homogeneous subgroups in the light of genetic, molecular and clinical aspects is challenging. The Montreal Classification for Crohn's disease was proposed in 2005 as an effort to characterize Crohn's disease patients according to recent clinical and research advances in the field of inflammatory bowel disease. Since its proposition, the Montreal Classification needs an ample validation and application among different populations around the world. To date, there are no known studies applying the Montreal Classification to a Brazilian cohort of Crohn's disease patients. OBJECTIVES: To apply the Montreal Classification to a Brazilian cohort of Crohn's disease patients at a referral center for inflammatory bowel disease in Northwestern São Paulo State, Brazil. METHODS: We selected 90 consecutive well-characterized Crohn's disease patients assisted at Inflammatory Bowel Disease Outpatient Clinic between January 1992 and January 2007, with a minimum follow-up of 2 years; data concerning demographic characteristics, clinical onset of disease, age at diagnosis, time of disease, location and behavior of disease, presence of extraintestinal manifestations, familial occurrence, perianal involvement, treatment with biological drugs, and history of surgical treatment were evaluated. RESULTS: Male patients were predominant (54%), with a mean age at diagnosis of 33 ± 14 years old, and a median followup of 5.5 years. Most of the patients were diagnosed between 17 and 40 years old (59%), and had disease located in terminal ileum 46%), with a nonstricturing, nonpenetrating behavior (71%). Time of disease was correlated with necessity of biological treatment, disease behavior, and surgical treatment (P<0.05). CONCLUSIONS: These study findings are consistent with results from other studies conducted among different populations, although a further multicentric study with a larger number of patients would be necessary to validate the Montreal Classification among Brazilian population.

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“…Older age at onset of Crohn's disease is indeed associated with more frequent colonic involvement. 14 In northern France, the incidence of MDS in the general population is approximately 2 to 4/10 5 , 15 and the incidence of IBD is approximately 6/10 5 . 16 Estimation of the chance for a given person to have both disorders would require knowing their prevalence in our region, which we do not.…”

Section: Discussionmentioning

confidence: 99%

Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature

et al. 1997

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We report seven patients with both myelodysplastic syndrome (MDS) and inflammatory bowel disease (IBD): Crohn's disease in six cases, ulcerative colitis in one case. We describe their characteristics, and those of 10 previously published similar cases are presented here. Median age at diagnosis of IBD (61 years) was high, as compared to the usual age at diagnosis of IBD. IBD was diagnosed first in nine cases, MDS first in one patient, and both diseases were diagnosed simultaneously in seven cases. Concerning IBD, there was a strong predominance of Crohn's disease (15/17 cases), with an unusually high frequency of colonic involvement (11/15 cases). MDS, in 12/17 cases, showed no excess of marrow blasts. Cytogenetic analysis was abnormal in five of the 13 evaluable cases. These observations suggest that the association between MDS and IBD may not be fortuitous in some cases, and that, in particular, patients with IBD and anemia of nonobvious origin should be evaluated for MDS. The pathogenesis of those associations, however, remains unclear.

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Crohn's disease: Influence of age at diagnosis on site and clinical type of disease

Cited by 311 publications

References 4 publications

Ulcerative colitis in a Southern European country: A national perspective

Ulcerative colitis in a Southern European country: A national perspective

The Montreal classification for Crohn's disease: clinical application to a Brazilian single-center cohort of 90 consecutive patients

Association between myelodysplastic syndromes and inflammatory bowel diseases. Report of seven new cases and review of the literature

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