Crohn's disease in the elderly. A statistical comparison with younger patients matched for sex and duration of disease

Harper, Philip C.

doi:10.1001/archinte.146.4.753

Cited by 50 publications

(41 citation statements)

References 6 publications

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“…[14][15][16][17][18] Patients with Crohn's disease or DD can have similar signs and symptoms, making clinical distinction between the two diseases difficult. 12,[19][20][21] One histologic pattern of Crohn's colitis has patchy inflammation with minimal or no crypt architectural distortion. A distinction between DDrelated inflammation and Crohn's disease may not be possible if only one biopsy tissue fragment is obtained.…”

Section: Discussionmentioning

confidence: 99%

Histology of the Mucosa in Sigmoid Colon Specimens With Diverticular Disease:Observations for the Interpretation of Sigmoid Colonoscopic Biopsy Specimens

Goldstein

Ahmad

1997

Am J Clin Pathol

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We examined retrospectively 100 sigmoid colon resection specimens removed for diverticulitis (DD [diverticular diseasel-diverticulitis), 53 adenocarcinoma specimens that also had diverticulosis (DD-adenocarcinoma), and 50 adenocarcinoma specimens that did not have DD (adenocarcinoma only) to study the mucosal changes that occur in DD. Documenting these histologic features could be helpful in deciphering changes seen in colonoscopic biopsy specimens from the sigmoid colon in older patients. Prominent mucosal folds were present in approximately 90% of all DD specimens. Increased mucosal lymphoplasmacytic inflammation at the bases of the prominent folds was present in 15% and 9% of DD-diverticulitis and DD-adenocarcinoma specimens, respectively. Eleven percent of the DD-diverticulitis and 4% of the DD-adenocarcinoma specimens had prolapselike mucosal abnormalities of the mucosa on the surface of the prominent mucosal folds. Mildly Diverticular disease (DD) is common in the sigmoid colon. In Western countries, it affects more than 30% of p e o p l e older than 60 y e a r s .

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Section: Discussionmentioning

confidence: 99%

Histology of the Mucosa in Sigmoid Colon Specimens With Diverticular Disease:Observations for the Interpretation of Sigmoid Colonoscopic Biopsy Specimens

Goldstein

Ahmad

1997

Am J Clin Pathol

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“…Early historical studies have suggested that the phenotypic clinical expression of Crohn's disease differs substantially, depending on the age of initial diagnosis [16][17][18][19][20] . This agedependent phenotypic clinical expression probably reflects the dynamic nature of the disorder [21] .…”

Section: Age-related Phenotypic Expressionmentioning

confidence: 99%

Long-term natural history of Crohn’s disease

Freeman¹

2009

WJG

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“…In one study, the interval between onset of symptoms and the diagnosis of CD was 6.4 years in the elderly as compared with 2.4 years in younger people [11]. The prevalence of extraintestinal manifestations of CD is unaffected by the age of onset [11].…”

Section: Opinion Statementmentioning

confidence: 98%

“…Up to 25% of patients with newly diagnosed CD are elderly; most studies have noted a female predominance of almost 2:1 when the disease presents later in life as compared with the relatively equal incidence of CD in both sexes when the disease has its onset in younger subjects [2]. CD limited to the colon (Crohn's colitis) occurs more commonly in the elderly than in the young, and there is a trend towards involvement of more distal sites in the colon just as with UC [6,[10][11][12][13]. The clinical presentation of CD in the elderly generally is similar to that in younger populations, with diarrhea and abdominal pain being the most frequent symptoms [3].…”

Section: Opinion Statementmentioning

confidence: 99%

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Inflammatory bowel disease after age 60

Greenwald

Brandt

2003

Curr Treat Options Gastro

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New-onset idiopathic inflammatory bowel disease (IBD) is not uncommon among the elderly, although more common are colonic infection, ischemia, or neoplasia, all of which may mimic IBD. Although the clinical presentation of IBD in the elderly often resembles that of younger subjects, atypical manifestations are common and may lead to difficulty in diagnosis. Much progress has been made in both medical and surgical therapy for IBD, but such therapy poses additional challenges in the elderly, who are more likely to experience adverse effects of medications or complications of surgery. The elderly generally have a favorable outcome to both medical and surgical therapy for IBD. Although concern about possible untoward effects of therapy is warranted, treatment should not be withheld because of fear of complications.

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Crohn's disease in the elderly. A statistical comparison with younger patients matched for sex and duration of disease

Cited by 50 publications

References 6 publications

Histology of the Mucosa in Sigmoid Colon Specimens With Diverticular Disease:Observations for the Interpretation of Sigmoid Colonoscopic Biopsy Specimens

Histology of the Mucosa in Sigmoid Colon Specimens With Diverticular Disease:Observations for the Interpretation of Sigmoid Colonoscopic Biopsy Specimens

Long-term natural history of Crohn’s disease

Inflammatory bowel disease after age 60

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