Crohn’s Disease Biologic Therapies Advances: A current review

Abstract

Crohn's Disease (CD) is an intestinal chronic inflammatory disease included in the group of inflammatory bowel disease. It is associated with an inflammatory process and may affect any part of the gastrointestinal tract. The pathogenesis of CD has become better understood owing to advances in genetic and immunologic technology. Studies suggest that the origin of the inflammation may be due to an exacerbated response of the immune system. The elevated production of inflammatory cytokines, such as tumor necrosis factor-alpha, in CD patients were described. The new therapeutic with biological agents were developed for CD patients who not respond to conventional therapy. These novel biologics has been shown frequently to decrease the inflammatory activity in the gut, with the goal to achieve remission with mucosal healing. The Infliximab therapy is one of more used in these patients. However, there are many patients who do not respond or lose response. Who do not respond to these therapeutics have other biologic therapeutics such as Certolizumab Pegol, Natalizumab, Vedolizumab, Ustekinumab and Secukinumab. It is necessary to analyse the effectiveness and safety of these treatments to see which is most effective.