Crohn’s Disease and Colorectal Cancer

Colorectal Cancer in Patients With Inflammatory Bowel Disease: The Need for a Real Surveillance Program

“…The main risk factors for the development of CRC in IBD patients are: long disease duration, extent of disease, young age at diagnosis, coexistence of primary sclerosing cholangitis (PSC), severity of inflammation, and family history of CRC. 5,6,22,25,26 Patients with IBD show a risk of developing CRC that is proportional to duration and extent of disease. The higher risk in this kind of patient is due to persistent colonic inflammation.…”

“…This suggests that early onset is not an independent risk factor for IBD-CRC. 4,5 Patients who developed CD at a young age were found to have a significantly increased RR of developing CRC. 19 Two studies reported the RR in 562 patients who were younger than aged 25 years at the time of diagnosis to be 21.46 (95% CI, 11.39-40.44; P < .01).…”

“…The association between inflammatory bowel disease (IBD) and colorectal cancer (CRC) has been recognized for nearly a century and it is known to be promoted by a process of cancerogenesis linked to chronic inflammation, in combination with a genetic predisposition. [1][2][3][4][5][6][7] In 1925 Crohn and Rosenberg were the first to clarify the relation between ulcerative colitis (UC) and CRC and in 1928 Bargen described 20 cases of CRC in patients with UC. 8 The magnitude of the risk of CRC in IBD is still the focus of heated debate.…”