Crohn Disease with Endoscopic Correlation: Single-Shot Fast Spin-Echo and Gadolinium-enhanced Fat-suppressed Spoiled Gradient-Echo MR Imaging

Low, Russell N.; Sebrechts, Christopher; Politoske, Douglas; Bennett, Michael T.; Flores, Sergio; Snyder, Richard J; Pressman, Jeffrey H

doi:10.1148/radiol.2223010811

Cited by 182 publications

(128 citation statements)

References 26 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…Studies have confirmed the capability of MRI to detect fistulae and abscesses (6,7). Actively inflamed fistulous tracts and abscesses have been reported to have characteristic enhancement features on dynamic contrastenhanced MRI (8).…”

mentioning

confidence: 87%

MRI appearance of perianal carcinoma in Crohn's disease

Lad

Haider

Brown

et al. 2007

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Detection of carcinoma in perianal Crohn's disease can be difficult. The purpose of this study was to describe the MRI appearance of anorectal cancer in patients with perianal Crohn's disease. A total of six patients with anorectal carcinoma (four mucinous adenocarcinoma, two squamous) in Crohn's disease were retrospectively reviewed. Axial T2 and dynamic postcontrast fat‐suppressed T1‐weighted gradient echo sequences were performed, and findings were compared with 18 noncancer patients with perianal fistulae in Crohn's disease. MRI characteristics of carcinoma were irregular inner wall contours and delayed mild enhancement of internal tissue. The combined features of an irregular internal wall and delayed enhancing tissue were seen exclusively in cancer patients. The four cases of mucinous adenocarcinoma all displayed a pattern of lobulated fluid‐filled cavities with delayed internal tissue enhancement. This pattern was not seen in any of the control cases. The presence of a double‐layered enhancement pattern was seen in both cases of squamous carcinoma and in only one of four cases of mucinous adenocarcinoma and one of 18 noncancer cases. The pattern of contrast enhancement is valuable in the MRI diagnosis of carcinoma in perianal Crohn's disease. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.

show abstract

mentioning

confidence: 87%

MRI appearance of perianal carcinoma in Crohn's disease

Lad

Haider

Brown

et al. 2007

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Chronic inflammatory disease, and in particular, CD, represents the most common application of MRI of small bowel [1][2][3][4][5]8,9,15,[28][29][30][31][32][33][34][35]38] .…”

Section: Inflammatory Bowel Disease (Cd) (Figures 1-4)mentioning

confidence: 99%

“…Using shorter TE (60-90 m) can obtain simultaneous evaluation of fluids, bowel wall and surrounding structures. The use of fat saturation pulses is a useful complement to the acquisition of T2-weighted sequences [2,13,14,[29][30][31] . Fat saturation causes an increase in contrast between bowel wall and the surrounding fat tissue.…”

Section: Sequencesmentioning

confidence: 99%

“…Scores ranging from 0 to approximately 600 with values below 150 are considered as remission and values over 150 as active disease. MR imaging was used to evaluate disease activity [9,[30][31][32][33][34][35]38,41,44,48,49] . Based on different experiences, contrast-enhanced(CE) fat-suppressed T1-weighted images offer the best correlation between MR findings and CDAI, although a correlation that used fatsuppressed T2-weighted images is also demonstrated.…”

Section: Assessment Of Disease Activitymentioning

confidence: 99%

“…Consequently, this technique is reliably applicable to the follow-up of patients with CD. MRI is able to detect significant variations in bowel wall thickness and contrast enhancement (CE), reflecting favorable clinical response to medical treatment of CD's relapse [30,34,49] . …”

mentioning

confidence: 99%

See 2 more Smart Citations

Updating magnetic resonance imaging of small bowel: Imaging protocols and clinical indications

Zhu¹,

Xu²,

Gong³

et al. 2008

WJG

View full text Add to dashboard Cite

High soft tissue contrast resolution, acquisition of multi-planar images and the possibility to obtain functional information make magnetic resonance an interesting imaging technique to evaluate the small bowel disease. The absence of ionizing radiation is an important feature of magnetic resonance imaging (MRI) examinations because inflammatory diseases such as Crohn's disease (CD) are studied most frequently, which are prevalent among children and young adults. MRI, using modern equipment and a rigorous technical approach, can offer detailed morphologic information and functional data on the small bowel. This article discusses the MRI protocols for small bowel and the MR imaging findings of small bowel diseases, such as CD and small bowel neoplasms. There are two main approaches for MRI of the small bowel: (1) study following oral administration of contrast material; and (2) study with distension of lumen obtained with contrast material that is introduced through a naso-jejunal tube (MR enteroclysis). Oral contrast agents for small bowel MRIOral contrast agents can be classified into positive, negative and biphasic categories according to their action on the signal intensity of bowel lumen.A positive agent is a paramagnetic substance that produces a high signal intensity on T1-weighted sequences. It reduces T1 relaxation time without, or only minimally, influencing T2 relaxation time. Because of the water content of the contrast solution, it also results in high signal intensity on T2-weighted images. Positive contrast agents include paramagnetic substances, such as gadolinium chelates, ferrous and manganic ions and manganese ions [12][13][14][15][16] . The use of positive oral contrast agents has been abandoned almost completely because a hyperintense lumen does not enable a clear differentiation with inflammatory parietal enhancement.A negative agent is a substance that produces a low signal intensity on T1-and T2-weighted sequences. These substances induce local inhomogeneity in the magnetic field that affects T1 and T2 relaxation time. T2 effects predominate and are caused by spin dephasing with a consequent loss of signal intensity. Negative contrast agents include perfluorooctyl bromide [17] , iron oxides [15,18] , and oral magnetic particles [14,15] . Barium sulfate, if used at high concentrations, can be considered a negative contrast agent [19] . Negative contrast agents are more favorable if hyperintense signal of the bowel wall and the surrounding fat tissue signs of acute inflammation have to be detected on T2-weighted sequences [15] . However, magnetic susceptibility on gradient echo sequences may alter image quality on breath-held T1-weighted images.The term "biphasic" recently was introduced to define those substances that show different signal intensities depending on different sequences [20] . The first group (hyperintense signal on T1-weighted images and hypointense signal on T2-weighted images) included manganese and substances that contain manganese, and gadolinium chelates, w...

show abstract

Magnetic Resonance Imaging of the Gastrointestinal Tract

Low

2004

CP Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

The early focus in body MR imaging was on imaging solid visceral organs, such as the liver and kidney. MRI of the extrahepatic abdomen, including the gastrointestinal (GI) tract, posed significant challenges related to motion artifacts and long exam times. However, new advances in MR imaging hardware and software have overcome all of these challenges, so that MR imaging of the GI tract has evolved to become a powerful and robust imaging technique. The improved efficiency of new MR scanners and software allows one to image the abdomen and pelvis rapidly using breath-hold sequences. The excellent contrast conspicuity of MR imaging when combined with gadolinium chelates and intraluminal contrast material facilitates depiction of mural diseases of the stomach, small intestine, and colon ( Fig.

show abstract

Crohn Disease with Endoscopic Correlation: Single-Shot Fast Spin-Echo and Gadolinium-enhanced Fat-suppressed Spoiled Gradient-Echo MR Imaging

Abstract: In patients with Crohn disease, gadolinium-enhanced fat-suppressed spoiled GRE MR imaging better depicted the extent and severity of intestinal disease compared with single-shot fast SE imaging.

Cited by 182 publications

References 26 publications

MRI appearance of perianal carcinoma in Crohn's disease

MRI appearance of perianal carcinoma in Crohn's disease

Updating magnetic resonance imaging of small bowel: Imaging protocols and clinical indications

Magnetic Resonance Imaging of the Gastrointestinal Tract

Contact Info

Product

Resources

About