Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics

Tang, Longguang; Zhang, Fuwu; Yu, Fang; Sun, Wenjing; Song, Menglin; Chen, Xiaoyuan; Zhang, Xianzhong; Sun, Xiaolian

doi:10.1016/j.biomaterials.2017.03.009

Cited by 80 publications

(63 citation statements)

References 46 publications

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“…As shown in Figure e, the character peak at 490 nm of DOX was observed in the UV–vis spectra of AuNR@PDOX, indicating that PDOX had been successfully conjugated on the AuNR surface . Similarly, the maximum absorption peak of PEG‐PCRVP was found to be 780 nm (Figure f), which is consistent with the absorption peak observed for the CR780 . This characteristic signal was also found in the UV–vis spectra of the core–shell hybrid nanostructure.…”

Section: Resultssupporting

confidence: 72%

Two‐Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli‐Responsive Polymer‐Gold Nanorod Assembly for Increased Tumor Penetration

Liu

Tong

et al. 2019

Adv Funct Materials

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A promising theranostic platform for solid tumors would deliver and release anticancer nanomedicine effectively in tumor cells. However, diverse biological barriers, especially related to the tumor microenvironment, impede these theranostic agents from reaching the tumor cell. Herein, a sequential pH and reduction-responsive polymer and gold nanorod (AuNR) core-shell assembly to overcome these barriers via a two-stage size decrease and disassembly of the nano platform responding to the specified tumor microenvironment are reported. The tumor uptake of the hybrid nanoparticle (NP) is 14.2% ID g −1 , which is two and four times higher than the noneresponsive hybrid NPs and small AuNR@PEG, respectively. After tumor uptake of the hybrid NPs, the disassembled ultrasmall AuNRs coated with a polymer of polymerized reduction-responsive doxorubicin (DOX) prodrug monomers penetrate into the solid tumor and lead to localized DOX release in the tumor cell. A linear increase in photoacustic (PA) effects from the PA activating polymer on an AuNR cluster surface indicates a critical role of electromagnetic fields in the AuNR assembly, which is consistent with the theoretical calculation results. Furthermore, the hybrid NP can serve as a promising deep-tissue PA and surfaceenhanced Raman scattering imaging agent for real-time in vivo investigation of physiological behaviors and deep tumor penetrating nanotherapy effects.

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Section: Resultssupporting

confidence: 72%

Two‐Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli‐Responsive Polymer‐Gold Nanorod Assembly for Increased Tumor Penetration

Liu

Tong

et al. 2019

Adv Funct Materials

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“…The C‐HSA‐BOPx‐IR825 NP was employed to test the pH in the tumor region by both ratiometric PA and fluorescence imaging. Other NIR dyes, including naphthalocyanines, phthalocyanine, croconine, squaraine, and Prussian blue, can also serve as PA contrast agents.…”

Section: Organic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

Self Cite

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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“…To specifically deliver the anticancer drugs to the tumor tissue for improved local‐regional chemotherapy, intelligent NDDSs have been developed for localized drug release at the tumor site. Among the stimuli exploited so far, near‐infrared (NIR) laser irradiation‐induced on‐demand drug delivery has attracted extensive attention due to high tissue penetrability and good biosafety of NIR light . Meanwhile, several independent groups including ourselves have demonstrated that NIR laser‐conducted photodynamic therapy (PDT) prompted up the drug release in the tumor tissue or inside the cancer cells by inducing reactive oxygen species (ROS) generation to degrade the ECM or endocytic vesicles .…”

Section: Introductionmentioning

confidence: 99%

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

Zhou

Feng

Wang

et al. 2017

Adv Funct Materials

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A reactive oxygen species (ROS)-activatable doxorubicin (Dox) prodrug vesicle (RADV) is presented for image-guided ultrafast drug release and local-regional therapy of the metastatic triple-negative breast cancer (TNBC). RADV is prepared by integrating a ROS-activatable Dox prodrug, a poly(ethylene glycol) (PEG)-modified photosensitizer pyropheophorbide-a, an unsaturated phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine, and cholesterol into one single nanoplatform. RADV is of extremely high drug loading ratio (27.5 wt%) by selfassembly of the phospholipid-mimic Dox prodrug into the liposomal bilayer membrane. RADV displays good colloidal stability to prevent premature drug leakage during the blood circulation and inert photochemotoxicity to avoid nonspecific side effect. RADV passively accumulates at tumor site through the enhanced permeability and retention effect when administrated systemically. Once deposited at the tumor site, RADV generates fluorescent and photoacoustic signals to guide near-infrared (NIR) laser irradiation, which can induce localized ROS generation, not only to trigger prodrug activation and ultrafast drug release but also conduct photodynamic therapy in a spatiotemporally controlled manner. In combination with NIR laser irradiation, RADV efficiently inhibits the tumor growth and distant metastasis of TNBC. Local-regional tumor therapy using intelligent theranostic nanomedicine might provide an alternative option for highly efficient treatment of the metastatic TNBC.

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Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics

Cited by 80 publications

References 46 publications

Two‐Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli‐Responsive Polymer‐Gold Nanorod Assembly for Increased Tumor Penetration

Two‐Stage Size Decrease and Enhanced Photoacoustic Performance of Stimuli‐Responsive Polymer‐Gold Nanorod Assembly for Increased Tumor Penetration

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Theranostic Prodrug Vesicles for Reactive Oxygen Species‐Triggered Ultrafast Drug Release and Local‐Regional Therapy of Metastatic Triple‐Negative Breast Cancer

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