Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats

Karayakali, Melike; Altınöz, Eyüp; Elbe, Hülya; Koca, Oğuzhan; Onal, Melike Ozgul; Bicer, Yasemin; Demır, Mehmet

doi:10.1007/s11356-023-25766-3

Cited by 5 publications

(4 citation statements)

References 87 publications

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“…In addition to the effects mentioned above, crocins also possess other pharmacological properties, such as antidiabetic, anti-atherosclerotic, and organ-protective effects. They also have a role in immune modulation and the treatment of glaucoma and diabetic retinopathy [70][71][72][73][74][75][76][77][78][79][80].…”

Section: Other Functionsmentioning

confidence: 99%

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

Hua,

Liu,

Yan

2024

Beilstein J. Org. Chem.

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Crocins are water-soluble apocarotenoids isolated from the flowers of crocus and gardenia. They exhibit various pharmacological effects, including neuroprotection, anti-inflammatory properties, hepatorenal protection, and anticancer activity. They are often used as coloring and seasoning agents. Due to the limited content of crocins in plants and the high cost of chemical synthesis, the supply of crocins is insufficient to meet current demand. The biosynthetic pathways for crocins have been elucidated to date, which allows the heterologous production of these valuable compounds in microorganisms by fermentation. This review article provides a comprehensive overview of the chemistry, pharmacological activity, biosynthetic pathways, and heterologous production of crocins, aiming to lay the foundation for the large-scale production of these valuable natural products by using engineered microbial cell factories.

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Section: Other Functionsmentioning

confidence: 99%

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

Hua,

Liu,

Yan

2024

Beilstein J. Org. Chem.

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“…Crocin (Cr), an exclusive water‐soluble carotenoid that is considered as one of the key constituents of saffron, is well identified as a potent antioxidant. Various studies have verified the ability of crocin to induce several pharmacological effects, such as prevention of cardiovascular diseases, 11 inhibition of tumor cell proliferation, 12 renal protection, 13 neuroprotection 14 and hepatoprotection 15 . Crocin can protect cells from oxidative stress by scavenging free radicals, notably superoxide anions.…”

Section: Introductionmentioning

confidence: 99%

“…Various studies have verified the ability of crocin to induce several pharmacological effects, such as prevention of cardiovascular diseases, 11 inhibition of tumor cell proliferation, 12 renal protection, 13 neuroprotection 14 and hepatoprotection. 15 Crocin can protect cells from oxidative stress by scavenging free radicals, notably superoxide anions. Crocin works with sperm cryopreservation and protects hepatocytes against toxins.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of crocin against testicular toxicity induced by ionizing radiation via AKT/FOXO pathway

El‐Sheikh,

Aziz,

Abdelrahman

et al. 2023

Environmental Toxicology

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Crocin, a pharmacologically active component of Crocus sativus L. (saffron), has been informed to be beneficial in the treatment of stress‐related oxidative impairment. In the present study, we examined the protective role of crocin against testicular damage induced by radiation (acute and fractionated) and the alteration of the AKT/FOXO signaling pathway. Male Wister albino rats were exposed to acute dose of 6 Gy and a fractionated dose of gamma radiation (2 Gy every 2 days up to 6 Gy total doses). Rats were pretreated intraperitoneally with crocin in a dose of 50 mg/kg for seven consecutive days prior to exposure to irradiation at a level of 6 Gy and during the fractionated irradiation of rats. Control groups were run concurrently. Ionizing radiation caused changes in the level of oxidative stress biomarkers manifested as elevation of thiobarbituric acid reactive substance, total nitrate/nitrite and reactive oxygen species (ROS) associated with a decrease in catalase as well as in the level of inflammatory parameters (decrease in expression of Nrf2 which was related to a significant increase in expression of NF‐κB p65). Irradiation produced cellular damage characterized by an increase in serum lactate dehydrogenase. These findings were aligned with increased expression of the forkhead box O‐1 (FOXO‐1) and activation of protein kinase B (AKT) pathway. Irradiation of rats led to reduction in serum testosterone level and testicular weights. Pretreatment with the indicated dose of crocin shielded against the changes in all the evaluated parameters. Administration of crocin can be introduced as a novel preclinical approach for regulation of testicular damage induced by radiation; via controlling the ongoing oxidative stress and inflammatory reaction as well as activation FOXO/AKT signaling pathway.

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“…Yapılan araştırmalar, AC maruziyetinin hemoglobin seviyelerinin düşmesine neden olabileceğini ve aynı zamanda oksidatif stresin artabileceğini önermektedir [13,14]…”

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Ratlarda Akrilamid Nedenli Hematoksisite Üzerine Karvakrolun Koruyucu Etkilerinin Araştırılması

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats

Cited by 5 publications

References 87 publications

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

The protective effect of crocin against testicular toxicity induced by ionizing radiation via AKT/FOXO pathway

Ratlarda Akrilamid Nedenli Hematoksisite Üzerine Karvakrolun Koruyucu Etkilerinin Araştırılması

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