Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity

Abou-Hany, Hadeer O.; Atef, Hoda; Said, Eman; El‐Kashef, Hassan A.; Salem, Hatem A.

doi:10.1016/j.etap.2018.03.017

Cited by 27 publications

(5 citation statements)

References 38 publications

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“…TLR4 inhibitory activity of crocin could lead to the protective effect against ischemia reperfusion‐induced acute kidney injury. Pretreatment with oral crocin improved renal histopathology, enhanced antioxidant defenses, and reduced oxidative stress via down‐regulation of TLR4 and IL6 expression (Abou‐Hany, Atef, Said, Elkashef, & Salem, 2018b). The hepatoprotective effect of crocin against cisplatin hepatotoxicity could be related to TLR4 antagonistic activity (Khedr et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Crocin molecular signaling pathways at a glance: A comprehensive review

Boozari

Rahbardar

2022

Phytotherapy Research

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Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus. Numerous in vitro and in vivo research projects have been published about the biological and pharmacological properties and toxicity of crocin. Crocin acts as a memory enhancer, anxiolytic, aphrodisiac, antidepressant, neuroprotective, and so on. Here, we introduce an updated and comprehensive review of crocin molecular mechanisms based on previously examined and mentioned in the literature. Different studies confirmed the significant effect of crocin to control pathological conditions, including oxidative stress, inflammation, metabolic disorders, neurodegenerative disorders, and cancer. The neuroprotective effect of crocin could be related to the activation of phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT)/mammalian target of rapamycin (mTOR), Notch, and cyclic‐AMP response element‐binding protein signaling pathways. The crocin also protects the cardiovascular system through the inhibitory effect on toll‐like receptors. The regulatory effect of crocin on PI3K/AKT/mTOR, AMP‐activated protein kinase, mitogen‐activated protein kinases (MAPK), and peroxisome proliferator‐activated receptor pathways can play an effective role in the treatment of metabolic disorders. The crocin has anticancer activity through the PI3K/AKT/mTOR, MAPK, vascular endothelial growth factor, Wnt/β‐catenin, and Janus kinases‐signal transducer and activator of transcription suppression. Also, the nuclear factor‐erythroid factor 2‐related factor 2 and p53 signaling pathway activation may be effective in the anticancer effect of crocin. Finally, among signaling pathways regulated by crocin, the most important ones seem to be those related to the regulatory effect on the PI3K/AKT/mTOR pathway.

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Section: Introductionmentioning

confidence: 99%

Crocin molecular signaling pathways at a glance: A comprehensive review

Boozari

Rahbardar

2022

Phytotherapy Research

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“…In a rat model of unilateral renal IR, oral administration of 20 mg/kg of crocin for 7 days also lightened renal injuries by attenuating oxidative stress and inflammatory responses. Attention to the results of this study demonstrates that improvement of renal function indexes was associated with the level enhanced of SOD and CAT activity and glutathione (GSH) and decreased concentration of MDA and IL-6 in rats exposed by corcin (Abou-Hany et al, 2018b). Doxorubicin is a cytotoxic antibiotic with anticancer properties.…”

Section: Effect On Urinary Systemmentioning

confidence: 86%

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

Anaeigoudari,

Kheirkhah‐Vakilabad

2023

Physiological Reports

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Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The outcomes of human and animal experiments indicate that therapeutic impacts of saffron and its constituents, crocin, crocetin, and safranal, mainly are mediated via inhibiting the inflammatory reactions and scavenging free radicals. It has been suggested that saffron and crocin extracted from it also up‐regulate the expression of sirtuin 1 (SIRT1) and nuclear factor erythroid 2‐related factor 2 (Nrf2), down‐regulate nuclear factor kappa B (NF‐κB) signaling pathway and untimely improve the body organs dysfunction. Inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 (COX2) also is attributed to crocin. The current review narrates the therapeutic effects of saffron and its constituents on various body systems through looking for the scientific databases including Web of Science, PubMed, Scopus, and Google Scholar from the beginning of 2010 until the end of 2022.

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“…In diabetic rats, crocin reduces serum creatinine levels, BUN, proteinuria, triglycerides and total cholesterol with concomitant increase in urinary creatinine clearance, improving kidney functions [ 28 , 54–56 ]. Additionally, in animal models of unilateral renal ischemia reperfusion injury, crocin pretreatment improves renal injury, as evidenced by reduced serum creatinine, BUN and proteinuria and enhanced creatinine clearance [ 27 ]. Moreover, in rats with nephropathy, crocin blocks diabetic nephropathy as indicated by decreased albumin and enhanced creatinine clearance [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Crocin improves the renal autophagy in rat experimental membranous nephropathy via regulating the SIRT1/Nrf2/HO-1 signaling pathway

Liu,

Cheng,

Wang

et al. 2023

Renal Failure

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Membranous nephropathy (MN) is a glomerular disease. Crocin is isolated from saffron and gardenia. Its antioxidant, anti-inflammatory, anti-hyperlipidemic, anti-atherosclerotic, anti-tumor, free-radical scavenging and neuroprotective activities have been well established. We investigated the biological functions of crocin and its related mechanisms in MN. We established an experimental passive Heymann nephritis (PHN) rat model induced by anti-Fx1A antiserum. The rats were divided into sham, sham + crocin, PHN, PHN + crocin, and PHN + enalapril groups. Blood samples and kidneys of rats were collected for estimation of biochemical parameters in serum and oxidative stress indicators in kidney tissues. Histopathological changes of renal tissues were evaluated by hematoxylin and eosin, periodic acid-Schiff (PAS) and Masson staining. The podocyte number was estimated by immunohistochemistry staining of Wilms tumor type 1 (WT1). The deposition of rat anti-rabbit IgG antibodies, complement C3 and C5b-9 was detected by immunofluorescence staining. Western blotting was performed to measure the levels of Sirtuin 1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1) and apoptosis-related proteins. The total cholesterol, triglycerides, creatinine, blood urea nitrogen, urine volume and urine albumin of PMN rats were significantly reduced by crocin. Additionally, crocin attenuated the renal histopathological changes. Moreover, the oxidative stress damage and podocyte loss and immune injury were relieved by crocin in PHN rats. Mechanistically, crocin administration activated the Sirt1/Nrf2/HO-1 pathways. The results provide a scientific basis that crocin could alleviate MN by inhibiting immune injury and podocyte damage through activating the Sirt1/Nrf2/HO-1 pathways.

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Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity

Cited by 27 publications

References 38 publications

Crocin molecular signaling pathways at a glance: A comprehensive review

Crocin molecular signaling pathways at a glance: A comprehensive review

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

Crocin improves the renal autophagy in rat experimental membranous nephropathy via regulating the SIRT1/Nrf2/HO-1 signaling pathway

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