Crocin attenuates the granular cells damages on the dentate gyrus and pyramidal neurons in the CA3 regions of the hippocampus and frontal cortex in the rat model of Alzheimer's disease

Hadipour, Mohammadmehdi; Meftahi, Gholam Hossein; Afarinesh, Mohammad Reza; Jahromi, Gila Pirzad; Hatef, Boshra

doi:10.1016/j.jchemneu.2020.101837

Cited by 20 publications

(12 citation statements)

References 46 publications

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“…The hippocampus and cortex are basic areas for cognitive function in the brain, as well as the key structures for learning and memory [ 44 ]. In patients with AD, the hippocampus DG and cortex regions are characterized by atrophy and neuronal density reduction [ 45 ]. HMD can cause impaired learning and memory by damaging hippocampus and cortex neurons [ 7 ], being consistent with other models [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet

Lang

Liu

et al. 2022

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Background: High methionine-diet (HMD) causes Alzheimer's disease (AD)-like symptoms. Previous studies have shown that Dendrobium nobile Lindle. alkaloids (DNLA) had potential benefits for AD. Object: Whether DNLA can improve AD-like symptoms induced by HMD is to be explored. Method: Mice were fed with 2% HMD diet for 11 weeks, the DNLA20 control group (20 mg/kg), DNLA10 group (10 mg/kg), and DNLA20 group (20 mg/kg) were administrated with DNLA for 3 months. Morris water maze test was used to detect learning and memory ability. Neuron damage was evaluated by HE and Nissl stainings. Levels of homocysteine (Hcy), beta-amyloid 1-42 (Aβ1-42), S-adenosine methionine (SAM), and S-adenosine homocysteine (SAH) were detected by ELISA. Immunofluorescence and western blotting (WB) were used to determine the expression of proteins. CPG island methylation. Results: Morris water maze test revealed that DNLA improved learning and memory dysfunction. HE, Nissl, and immunofluorescence stainings showed that DNLA alleviated neuron damage and reduced the 5-methylcytosine (5-mC), Aβ1-40, and Aβ1-42 levels. DNLA also decreased the levels of Hcy and Aβ1-42 in the serum, along with decreased SAM/SAH levels in the liver tissue. WB results showed that DNLA down-regulated the expression of the amyloid-precursor protein (APP), presenilin-1 (PS1), beta-secretase-1 (BACE1), DNA methyltransferase1 (DNMT1), Aβ1-40, and Aβ1-42 proteins. DNLA also up-regulated the expression of the protein of insulin-degrading enzyme (IDE), neprilysin (NEP), DNMT3a, and DNMT3b. Meanwhile, DNLA increased CPG island methylation levels of APP and BACE1 genes. Conclusions: DNLA alleviated AD-like symptoms induced by HMD via the DNA methylation pathway.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet

Lang

Liu

et al. 2022

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“… 2019 ; Hadipour et al. 2021 ). There is accumulating evidence that crocin demonstrates a variety of bioactivities such as antitumor, antioxidant, anti-inflammatory, anti-hyperlipidaemic, anti-atherosclerotic, free-radical scavenging and neuroprotective activities (Naghizadeh et al.…”

Section: Introductionmentioning

confidence: 99%

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways

Gao

Zhao

et al. 2022

Pharmaceutical Biology

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Context Crocin has been reported to have multiple bioactivities. However, the effect of crocin administration on caecal ligation and puncture (CLP)-induced sepsis remains unknown. Objective We investigated the effects of crocin on CLP-induced sepsis in mice and the underlying mechanism of action. Materials and methods Five experimental groups ( n = 10) of BALB/c mice were used: control, CLP (normal saline) and CLP + crocin (50, 100 and 250 mg/kg, 30 min prior to CLP). Mice were sacrificed 24 h after CLP. Liver, kidney and lung histopathology, indicator levels, apoptotic status, pro-inflammatory cytokines and relative protein levels were evaluated. Results Compared to the CLP group, crocin treatment significantly increased the survival rate (70%, 80%, 90% vs. 30%). Crocin groups exhibited protection against liver, kidney and lung damage with mild-to-moderate morphological changes and lower indicator levels: liver (2.80 ± 0.45, 2.60 ± 0.55, 1.60 ± 0.55 vs. 5.60 ± 0.55), kidney (3.00 ± 0.71, 2.60 ± 0.55, 1.40 ± 0.55 vs. 6.20 ± 0.84) and lungs (8.00 ± 1.59, 6.80 ± 1.64, 2.80 ± 0.84 vs. 14.80 ± 1.79). The proinflammatory cytokines (IL-1β, TNF-α, IL-6 and IL-10 levels in the crocin groups) were distinctly lower and the apoptotic index showed a significant decrease. Crocin administration significantly suppressed p38 MAPK phosphorylation and inhibited NF-κB/IκBα and Bcl-2/Bax activation. Discussion and conclusions Pre-treatment with crocin confers protective effects against CLP-induced liver, kidney and lung injury, implying it to be a potential therapeutic agent.

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“…Crocin may be a potential therapeutic candidate for lipopolysaccharide (LPS)‐induced depressive‐like behaviors via inhibiting the NLRP3 inflammasome and attenuating microglial M1‐polarization (Zhang et al, 2018). Crocin can improve synaptic loss and neuronal death in Alzheimer's rats, possibly by reducing neuronal apoptosis (Hadipour, Meftahi, Afarinesh, Jahromi, & Hatef, 2021). However, the effect of crocin on cognitive impairment associated with atherosclerosis has not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR^−/− mice fed a high‐fat/cholesterol diet

Song

Han

Gao

et al. 2022

Phytotherapy Research

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Crocin has been extensively investigated in treating neurodegenerative diseases.However, its effect on cognitive impairment associated with atherosclerosis remains unknown. The present study aimed to explore the potential mechanism of crocin on cognitive impairment in a mouse model of atherosclerosis. LDLR À/À mice fed a highfat/cholesterol diet were administered variable-dose crocin for 56 days through gavage. Biochemical tests showed that serum triglycerides and circulating lipopoly-

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Crocin attenuates the granular cells damages on the dentate gyrus and pyramidal neurons in the CA3 regions of the hippocampus and frontal cortex in the rat model of Alzheimer's disease

Cited by 20 publications

References 46 publications

Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet

Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways

Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR^−/− mice fed a high‐fat/cholesterol diet

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Crocin attenuates the granular cells damages on the dentate gyrus and pyramidal neurons in the CA3 regions of the hippocampus and frontal cortex in the rat model of Alzheimer's disease

Cited by 20 publications

References 46 publications

Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet

Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs via inhibition of p38 MAPK/NF-κB and Bax/Bcl-2 signalling pathways

Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR−/− mice fed a high‐fat/cholesterol diet

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Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR^−/− mice fed a high‐fat/cholesterol diet