Crocin, a natural molecule with potentially beneficial effects against skin ageing

Abstract

Results could designate this molecule as a promising skin ageing prevention cosmetic agent. Of note, some of these effects could be mediated by protein O-glycosylation and interaction of crocin with osidic receptors of keratinocytes.

Anti-aging Effects of Select Botanicals: Scientific Evidence and Current Trends

“…Crocin is responsible for the color of saffron [45]. Crocin is also found in the fruit of Gardenia jasminoides Ellis [45]. It is classified as a carotenoid glycoside [45].…”

“…Crocin has antioxidant effects, protects squalene against UV-induced peroxidation, and prevents the release of inflammatory mediators [45]. The antioxidant effect has been demonstrated in in vitro assays that showed superior antioxidant activity compared to Vitamin C [45].…”

“…Crocin has antioxidant effects, protects squalene against UV-induced peroxidation, and prevents the release of inflammatory mediators [45]. The antioxidant effect has been demonstrated in in vitro assays that showed superior antioxidant activity compared to Vitamin C [45]. Additionally, crocin inhibits UVA-induced cell membrane peroxidation and inhibits the expression of numerous pro-inflammatory mediators including IL-8, PGE-2, IL-6, TNF-α, IL-1α, and LTB4 [45,46].…”

“…The antioxidant effect has been demonstrated in in vitro assays that showed superior antioxidant activity compared to Vitamin C [45]. Additionally, crocin inhibits UVA-induced cell membrane peroxidation and inhibits the expression of numerous pro-inflammatory mediators including IL-8, PGE-2, IL-6, TNF-α, IL-1α, and LTB4 [45,46]. It also decreases the expression of multiple NF-κB dependent genes [45].…”

“…Additionally, crocin inhibits UVA-induced cell membrane peroxidation and inhibits the expression of numerous pro-inflammatory mediators including IL-8, PGE-2, IL-6, TNF-α, IL-1α, and LTB4 [45,46]. It also decreases the expression of multiple NF-κB dependent genes [45]. In a study using cultured human fibroblasts, crocin reduced UV-induced ROS, promoted expression of extracellular matrix protein Col-1, and decreased the number of cells with senescent phenotypes after UV radiation [47].…”