Crocetin Prevents Dexamethasone-Induced Insulin Resistance in Rats

Liu, Xi; Qian, Zhiyu; Shen, Xiangchun; Wen, Ning; Zhang, Ya-Bing

doi:10.1055/s-2005-871248

Cited by 57 publications

(41 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have also demonstrated the potential of crocetin to reduce insulin resistance in rats (Xi, Qian, Shen, Wen, & Zhang, 2005;Xi et al, 2007). In a 2005 study, rats were administered dexamethasone (a glucocorticoid that contributes to insulin resistance) and dexamethasone+ crocetin for a six-week period.…”

Section: Insulin Resistancementioning

confidence: 98%

Chemical and biological properties of the world's most expensive spice: Saffron

Melnyk

Wang

Marcone

2010

Food Research International

305

189

View full text Add to dashboard Cite

Section: Insulin Resistancementioning

confidence: 98%

Chemical and biological properties of the world's most expensive spice: Saffron

Melnyk

Wang

Marcone

2010

Food Research International

305

189

View full text Add to dashboard Cite

“…1, >98%, HPLC), a carotenoid compound, was isolated from Gardenia jasminoids Ellis by our laboratory (Xi et al, 2005). Our recent study showed that crocetin inhibits angiotensin II (Ang II)-induced proliferation of VSMCs (Zhou et al, 2006).…”

Section: Introductionmentioning

confidence: 98%

Protein kinase C pathway is involved in the inhibition by crocetin of vascular smooth muscle cells proliferation

Zhou¹,

Xiang²,

He³

et al. 2010

Phytotherapy Research

View full text Add to dashboard Cite

Crocetin is a natural carotenoid compound isolated from Gardenia jasminoids Ellis. Our previous study showed that crocetin inhibits angiotensin II (Ang II)-induced proliferation of vascular smooth muscle cells (VSMCs). The present study investigated the involvement of the protein kinase C (PKC) pathway in the growth-inhibitory action of crocetin in VSMCs. The findings showed that PKC activity in the membrane fraction of VSMCs increased following stimulation with Ang II, which was suppressed significantly by pretreating the cells with crocetin. Inhibition of PKC activity by crocetin appeared to be associated with growth inhibition in VSMCs, because chelerythrine chloride, a specific PKC inhibitor, likewise decreased cell proliferation. PKC-a, a conventional PKC isoform, was detected in bovine aorta VSMCs by RT-PCR and western blotting analysis. Crocetin inhibited Ang II-induced membrane translocation of PKC-a, and the inhibition of crocetin on PKC activity in membrane fraction coincided with its suppression on membrane translocation of PKC-a. In addition, Ang II-induced mRNA expressions of c-fos, c-jun and c-myc were also decreased by crocetin. Taken together, the data suggest that the inhibition by crocetin of PKC activity, at least in part due to inactivation of PKC-a, and the subsequent suppression of proto-oncogene expressions might mediate its inhibitory effect on VSMCs proliferation.

show abstract

“…Further reasons to focus on CCT are that this compound can be obtained from various sources other than saffron, such as Gardenia jasminoides Ellis, and it has favorable cardiovascular effects, such as a decrease in oxidative stress [12,13,14] and inhibitory action on the development of insulin resistance [15,16]. Other related studies have determined that CCT can ameliorate the effects of atherosclerosis and related diseases [12,15,16,17,18,19,20]. …”

Section: Introductionmentioning

confidence: 99%

Crocetin, a Carotenoid Derived from Saffron (<b><i>Crocus sativus</i></b> L.), Improves Acetylcholine-Induced Vascular Relaxation in Hypertension

Mancini

Serrano-Díaz²,

Nava

et al. 2014

J Vasc Res

View full text Add to dashboard Cite

Background: Hypertension is associated with endothelial dysfunction characterized by decreased vasorelaxation. Crocetin, a bioactive compound of saffron, exhibits favorable cardiovascular properties. We analyze the vasomodulatory effects of crocetin in hypertension. Methods: Myographical experiments were performed to compare the relaxation induced by acetylcholine (ACH) on aortic rings from normotensive (Wistar) and hypertensive (SHR) rats, incubated with or without crocetin or saffron extract and L-NAME or indomethacin. Extracts were also assayed in deendothelialized rings. UV-vis spectrophotometry and HPLC-DAD were used to characterize and quantify the saffron used. Results: Crocetin enhanced the ACH relaxations in aorta from hypertensive (strongly) and normotensive rats (weakly). Saffron extract did not modify this. Crocetin plus L-NAME abolished the relaxant response in SHR but not in Wistar aorta. Crocetin plus indomethacin did not modify the indomethacin response in either SHR or Wistar aorta. Crocetin in rubbed segments did not modify the ACH responses. In contrast, saffron increased this response in rubbed segments from SHR but not Wistar rats. Conclusion: Crocetin exerts healthy vasomodulatory effects in hypertension, strongly improving endothelium-dependent ACH relaxations via endothelial nitric oxide but not the cyclooxygenase pathway. This work proposes that crocetin supplements are a possible complement in the therapy of hypertension.

show abstract

Crocetin Prevents Dexamethasone-Induced Insulin Resistance in Rats

Cited by 57 publications

References 28 publications

Chemical and biological properties of the world's most expensive spice: Saffron

Chemical and biological properties of the world's most expensive spice: Saffron

Protein kinase C pathway is involved in the inhibition by crocetin of vascular smooth muscle cells proliferation

Crocetin, a Carotenoid Derived from Saffron (<b><i>Crocus sativus</i></b> L.), Improves Acetylcholine-Induced Vascular Relaxation in Hypertension

Contact Info

Product

Resources

About