Crocetin from the tubular calyx of<i>Nyctanthes arbor-tristis</i>

Gadgoli, Chhaya; Shelke, Sandeep K.

doi:10.1080/14786411003754363

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…Peak 2 (Figure 2(b)) (RT = 20.509 min, λ = 440 nm, and MW = 652.27) (Figure 4) had [M + H] + at m/z 653.1994 and was identified as carotenoid, glycosides, namely, β -monogentiobioside ester of α -Crocetin (or Crocin-3) with loss of 1,5-anhydro-D-glucitol that ion appeared at m/z 165.0651 and m/z 491 carotenoid ester with other fragments at m/z 459, 315, and 147 [22]. The reddish-orange coloured tubular calyx of flower of N. arbortristis is due to carotenoid pigments (Crocetin and its derivatives) which are reported from the flowers of this plant [22, 23]. …”

Section: Resultsmentioning

confidence: 99%

In VitroAntioxidant, Antiproliferative, and Phytochemical Study in Different Extracts ofNyctanthes arbortristisFlowers

Manjulatha

Avadhanula

Setty

2014

BioMed Research International

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Nyctanthes arbortristis L. (Oleaceae) is widely used in the Indian system of traditional medicine and is reported to have various biological activities. The present study was intended to evaluate the antioxidant and antiproliferative activities of flower extracts of Nyctanthes arbortristis. The shade dried flowers were extracted with 95% ethanol under sonication and the antioxidant activities were investigated using in vitro assays along with the determination of phytochemical constituents (total polyphenol and total flavonoid). Arborside C and β-monogentiobioside ester of α-Crocetin were identified in crude active extracts through LCMS/MS analysis. The antiproliferative activity was carried out by MTT assay by employing different human cancer cell lines. The lowest IC50 value of 24.56 ± 6.63 μg/mL was observed against Colo 205 cell line. The extract exhibited significant antioxidant and antiproliferative properties and the observed biological activities in this study provide scientific validation of ethnomedicinal use of this plant.

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Section: Resultsmentioning

confidence: 99%

In VitroAntioxidant, Antiproliferative, and Phytochemical Study in Different Extracts ofNyctanthes arbortristisFlowers

Manjulatha

Avadhanula

Setty

2014

BioMed Research International

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“…Saffron is a Chinese traditional herb, and Crocetin is the major constituent of saffron, which has recently found to have multiple pharmacological effects including anticancer [15][16][17]. However, the effects of Crocetin on asthma as well as the underlying mechanisms have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Crocetin Activates Foxp3 Through TIPE2 in Asthma-Associated Treg Cells

Ding

Zhang

et al. 2015

Cell Physiol Biochem

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Background/Aims: Regulatory T cells (Treg) are critical regulators of asthma. Crocetin is isolated from Chinese herb saffron and is a natural carotenoid dicarboxylic acid with anti-inflammatory potential. However, the effects of Crocetin on asthma as well as the underlying mechanisms have not been studied. Methods: We used Crocetin to treat mice with established ovalbumin (OVA)-induced asthma. We purified CD4+CD25+ Treg cells by flow cytometry and analyzed the levels of two immunoregulatory proteins Foxp3 and tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2) in Treg cells. We depleted either Foxp3 or TIPE2 in mouse lung through lentivirus-mediated delivery of shRNA, and analyzed their effects on severity of asthma and Treg cells after Crocetin treatment. Results: Crocetin treatment significantly reduced the severity of an ovalbumin (OVA)-induced asthma in mice. Moreover, Crocetin significantly increased the levels of TIPE2 and Foxp3 in Treg cells and the number of Treg cells. Depletion of Foxp3 abolished the increased in Treg cells, and the effects of Crocetin on the severity of asthma, without affecting TIPE2 levels in Treg cells. On the other hand, depletion of TIPE2 abolished both the increased in Treg cells and the effects of Crocetin on the severity of asthma, through suppressing Foxp3. Conclusion: Crocetin may activate Foxp3 through TIPE2 in asthma-associated Treg cells to mitigate the severity of asthma.

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“…The elucidation of the structure through a detailed spectroscopic study revealed that the carotenoid molecule is Crocetin, which is the major aglycone present in the stigma of Crocus sativus. The compound exhibited a good membrane stabilizing activity as compared to the corresponding glycoside crocin (Gadgoli and Shelke, 2010). The decoction of the leaves of Nyctanthes arbortristis Linn (Harsingar) is widely used in Ayurveda system of medicine for the treatment of sciatica, arthritis, fevers, and various painful conditions and as laxative.…”

Section: Phytochemical and Pharmacogical And Tissue Culture Study Of mentioning

confidence: 99%

Systemic Review on Anti-Sciatica Plant “Night Jasmine” (Nyctanthes arbortristis Linn.)

Kumar¹,

Rathi²,

Tyagi³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Crocetin from the tubular calyx ofNyctanthes arbor-tristis

Cited by 21 publications

References 12 publications

In VitroAntioxidant, Antiproliferative, and Phytochemical Study in Different Extracts ofNyctanthes arbortristisFlowers

In VitroAntioxidant, Antiproliferative, and Phytochemical Study in Different Extracts ofNyctanthes arbortristisFlowers

Crocetin Activates Foxp3 Through TIPE2 in Asthma-Associated Treg Cells

Systemic Review on Anti-Sciatica Plant “Night Jasmine” (Nyctanthes arbortristis Linn.)

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