CROC-4: A Novel Brain Specific Transcriptional Activator of c-fos Expressed from Proliferation through to Maturation of Multiple Neuronal Cell Types

Jeffrey, Peter L.; Capes‐Davis, Amanda; Dunn, Joanne; Tolhurst, Ornella; Seeto, Greg; Hannan, Anthony J.; Lin, Stanley L.

doi:10.1006/mcne.2000.0866

Cited by 26 publications

(28 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rat, CROC-4 expression is associated with cells proliferating around the fourth ventricle and in the developing optic vesicle. It has been suggested, based on its localization with proliferating and migrating cells during early brain development, that CROC-4 participates in pathways involved in modulating cellular architecture during neuronal development and plasticity (Jeffrey et al 2000). The same could be FIGURE 3.…”

Section: Resultsmentioning

confidence: 96%

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

Baskerville¹,

Bartel²

2005

RNA

1,304

1,069

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

Baskerville¹,

Bartel²

2005

RNA

1,304

1,069

View full text Add to dashboard Cite

“…For instance CROC-4, a transcriptional activator of c-fos, was identified in the cluster of genes specific to the 50-day-old fetal brain libraries. This gene has been described as being expressed in early development of the brain and is involved in cell proliferation and differentiation [44]. Large numbers of ribosomal proteins and hypothetical proteins were also observed in these brain libraries.…”

Section: Resultsmentioning

confidence: 99%

Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags

Gorodkin

Cirera

Hedegaard³

et al. 2007

Genome Biol

View full text Add to dashboard Cite

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Sino-Danish PigEST resource

A resource consisting of one million porcine ESTs is described, providing an essential resource for annotation, comparative genomics, assembly of the pig genome sequence, and further porcine transcription studies.

Abstract Background: Knowledge of the structure of gene expression is essential for mammalian transcriptomics research. We analyzed a collection of more than one million porcine expressed sequence tags (ESTs), of which two-thirds were generated in the Sino-Danish Pig Genome Project and one-third are from public databases. The Sino-Danish ESTs were generated from one normalized and 97 non-normalized cDNA libraries representing 35 different tissues and three developmental stages.

show abstract

“…4A). The miR-9-1 primary transcript derives from the C1orf61 locus which encodes for CROC-4 protein, a transcriptional activator for the c-fos proto-oncogene (14). An EST database analysis revealed the existence of an internal product of the C1orf61 locus.…”

Section: Figmentioning

confidence: 99%

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

Bazzoni

Rossato

Fabbri

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

518

470

View full text Add to dashboard Cite

Inflammation involves a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanisms. Recent studies have shown that microRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide noncoding RNAs, contribute to the regulation of inflammation by repressing gene expression at the posttranscriptional level. In this study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after TLR4 activation. miR-9 is also induced by TLR2 and TLR7/8 agonists and by the proinflammatory cytokines TNF-␣ and IL-1␤, but not by IFN␥. Among the 3 different genes encoding miR-9 precursors in humans, we show that LPS selectively induces the transcription of miR-9 -1 located in the CROC4 locus, in a MyD88-and NF-B-dependent manner. In PMN and monocytes, LPS regulates NFKB1 at both the transcriptional and posttranscriptional levels, and a conserved miR-9 seed sustained a miR-9-dependent inhibition of the NFKB1 transcript. Overall, these data suggest that TLR4-activated NF-B rapidly increases the expression of miR-9 that operates a feedback control of the NF-B-dependent responses by fine tuning the expression of a key member of the NF-B family.inflammation ͉ innate immunity ͉ Toll-like receptors ͉ cytokines ͉ NFKB1

show abstract

CROC-4: A Novel Brain Specific Transcriptional Activator of c-fos Expressed from Proliferation through to Maturation of Multiple Neuronal Cell Types

Cited by 26 publications

References 55 publications

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

Contact Info

Product

Resources

About