CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons

Liu, Zhi-Zhi; Zhu, Jian; Wang, Chang-Ling; Wang, Xin; Han, Yingying; Liu, Lingyan; Xu, Hong

doi:10.1155/2018/8791304

Cited by 8 publications

(13 citation statements)

References 42 publications

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“…Misregulation of sema3d alone does not, however, result in defects as intense as we observed, but rather in guidance errors of some RGC axons, leading to mixed ipsilateral and contralateral projections [28]. The same was shown after inactivation of other parts of Semaphorin signaling, including nrp1a, sema3e, adcy8, crmp4 and the sema-independent islr2 [27,45,55,56]. For rgmd, lrig1 and ephb2b, no mutant, KO or KD phenotype regarding RGC projections has been identified and they were not differentially regulated following Cyclopamine treatment.…”

Section: Discussionsupporting

confidence: 76%

BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish

Knickmeyer

Mateo

Heermann

2021

IJMS

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Decussation of axonal tracts is an important hallmark of vertebrate neuroanatomy resulting in one brain hemisphere controlling the contralateral side of the body and also computing the sensory information originating from that respective side. Here, we show that BMP interferes with optic chiasm formation and RGC pathfinding in zebrafish. Experimental induction of BMP4 at 15 hpf results in a complete ipsilateral projection of RGC axons and failure of commissural connections of the forebrain, in part as the result of an interaction with shh signaling, transcriptional regulation of midline guidance cues and an affected optic stalk morphogenesis. Experimental induction of BMP4 at 24 hpf, resulting in only a mild repression of forebrain shh ligand expression but in a broad expression of pax2a in the diencephalon, does not per se prevent RGC axons from crossing the midline. It nevertheless shows severe pathologies of RGC projections e.g., the fasciculation of RGC axons with the ipsilateral optic tract resulting in the innervation of one tectum by two eyes or the projection of RGC axons in the direction of the contralateral eye.

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Section: Discussionsupporting

confidence: 76%

BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish

Knickmeyer

Mateo

Heermann

2021

IJMS

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“…Misregulation of sema3d alone does not, however, result in defects as intense as we observed, but rather in guidance errors of some RGC axons, leading to mixed ipsi-and contralateral projections (Sakai and Halloran, 2006). The same was shown after inactivation of other parts of Semaphorin signaling, including nrp1a, sema3e, adcy8, crmp4, and the sema-independent islr2 (Dell et al, 2013;Xu et al, 2010;Liu et al, 2018;Panza et al, 2015). For rgmd, lrig1, and ephb2b, no mutant, KO or KD phenotype regarding RGC projections has been identified and they were not differentially regulated following Cyclopamine treatment.…”

Section: Discussionsupporting

confidence: 72%

BMP signaling interferes with optic chiasm formation and retinal ganglion cell pathfinding in zebrafish

Knickmeyer

Mateo

Heermann³

2021

Preprint

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Decussation of axonal tracts is an important hallmark of vertebrate neuroanatomy resulting in one brain hemisphere controlling the contralateral side of the body and also computing the sensory information originating from that respective side. Here, we show that BMP interferes with optic chiasm formation and RGC pathfinding in zebrafish. Experimental induction of BMP4 at 15 hpf results in a complete ipsilateral projection of RGC axons and failure of commissural connections of the forebrain in part being the result of an interaction with shh signaling, transcriptional regulation of midline guidance cues and an affected optic stalk morphogenesis. Experimental induction of BMP4 at 24 hpf, resulting in only a mild repression of forebrain shh ligand expression but in a broad expression of pax2a in the diencephalon, does not per se prevent RGC axons from crossing the midline. It nevertheless shows severe pathologies of RGC projections e.g. the fasciculation of RGC axons with the ipsilateral optic tract resulting in the innervation of one tectum by two eyes or the projection of RGC axons in the direction of the contralateral eye.

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“…DPYSL2 knockout results in reduced dendritic spine density (Hiroko et al, 2016), and its dysfunction has been implicated in neurodevelopmental and psychiatric disorders with delayed onset, such as autism spectrum disorders and schizophrenia (Beasley et al, 2006;Hong et al, 2005). DPYSL2 is associated with neuronal microtubules and regulates axonal growth, and growth cone guidance (Liu et al, 2018;Hiroko et al, 2016). Brain slices from DPYSL2 knockout mice show abnormal long-term potentiation of synaptic transmission (Zhang et al, 2016), and behaviorally the mice exhibit increased locomotion, social, cognitive, and affective behavioral impairments (Zhang et al, 2016).…”

Section: Adev-il-10mentioning

confidence: 99%

Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability

Chaudhuri

Dasgheyb

DeVine

et al. 2019

Glia

101

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Extracellular vesicles have now emerged as key players in cell‐to‐cell communication. This is particularly important in the central nervous system, where glia–neuron cross‐talk helps maintain normal neuronal function. Astrocyte‐derived extracellular vesicles (ADEVs) secreted constitutively promote neurite outgrowth and neuronal survival. However, extracellular stimuli can alter the cargo and downstream functions of ADEVs. For example, ADEVs secreted in response to inflammation contain cargo microRNAs and proteins that reduce neurite outgrowth, neuronal firing, and promote neuronal apoptosis. We performed a comprehensive quantitative proteomic analysis to enumerate the proteomic cargo of ADEVs secreted in response to multiple stimuli. Rat primary astrocytes were stimulated with a trophic stimulus (adenosine triphosphate, ATP), an inflammatory stimulus (IL‐1β) or an anti‐inflammatory stimulus (IL10) and extracellular vesicles secreted within a 2 hr time frame were collected using sequential ultracentrifugation method. ADEVs secreted constitutively without exposure to any stimulus were used a control. A tandem mass tag‐based proteomic platform was used to identify and quantify proteins in the ADEVs. Ingenuity pathway analysis was performed to predict the downstream signaling events regulated by ADEVs. We found that in response to ATP or IL10, ADEVs contain a set of proteins that are involved in increasing neurite outgrowth, dendritic branching, regulation of synaptic transmission, and promoting neuronal survival. In contrast, ADEVs secreted in response to IL‐1β contain proteins that regulate peripheral immune response and immune cell trafficking to the central nervous system.

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CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons

Cited by 8 publications

References 42 publications

BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish

BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish

BMP signaling interferes with optic chiasm formation and retinal ganglion cell pathfinding in zebrafish

Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability

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