A systematic computer-aided analysis of the process model is used as a presolution step for integration of design and control problems [Russel et al. Comput. Chem. Eng. 2002, 26 (2), 213-225]. In this paper, this analysis is applied to an energy-integrated distillation pilot plant to identify the set of common variables that have important roles in design as well as in control structure definition. This identified set of variables is used to develop an actuator structure for the pilot plant for the purpose of optimizing control by exploiting interactions between plant design and control design. The process model is presented first, followed by a model analysis, which directly leads to the coupling among process design, process sensitivity, and actuator structure. Furthermore, the analysis reveals how the heat pump should operate the pilot plant using a set of actuators on the heat-pump side to achieve mainly independent control of the boil-up flow rate and column pressure.