Critically ill systemic lupus erythematosus patients referred to the intensive care unit of Fayoum University Hospital: Frequency, complications and outcome

Momtaz, Osama; Senara, Soha; Zaky, Sherif; Mohammed, Eman Sameh

doi:10.1016/j.ejr.2018.05.003

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Overall, these 35 studies comprise a total of 8158 patients. 8, 14–18, 20, 21, 23, 25, 26, 29–52 The largest cohort was retrieved from a public database, including 34,991 admissions of patients with SLE admitted to the ICU. 52…”

Section: Resultsmentioning

confidence: 99%

“…96 Nine studies reported the age of patients and the time of SLE diagnosis when the death occurred. 16, 29, 30, 32, 39, 41, 43, 45, 53 The median age was 37.3 (IQR: 30.2–45.5) years, and the median time after SLE diagnosis was 6.35 (IQR: 3.6–10.6) years. In eight of the studies, the leading cause of mortality was infection, and in one of them was CAPS.…”

Section: Discussionmentioning

confidence: 99%

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Systemic lupus erythematosus in the intensive care unit: a systematic review

Suárez-Avellaneda

Quintana

Aragón

et al. 2020

Lupus

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Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous pathophysiologic mechanisms and diverse clinical manifestations. SLE is a frequent cause of intensive care unit (ICU) admissions. Multiple studies with controversial findings on the causes, evolution and outcomes of ICU-admitted patients with SLE have been published. The aim of this paper is to review the literature reporting the clinical characteristics and outcomes, such as mortality and associated factors, in such patients. Among the main causes of ICU admissions are SLE disease activity, respiratory failure, multi-organ failure and infections. The main factors associated with mortality are a high Acute Physiology and Chronic Health Evaluation (APACHE) score, the need for mechanical ventilation, and vasoactive and inotropic agent use. Reported mortality rates are 18.4%–78.5%. Therefore, it is important to evaluate SLE disease severity for optimizing clinical management and patient outcomes.

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