Critically Ill Patients with Middle East Respiratory Syndrome Coronavirus Infection

Abstract

This article is one of ten reviews selected

Prevalence and risk factors of mortality among hospitalized patients with COVID-19: A systematic review and Meta-analysis

“…Currently, the total infected cases and the death of patients with SARS-CoV-2 virus is unpredictably high as compared to the previous two outbreaks [15][16][17][18][19][21][22][23][34][35][36][60][61][62] . The lower rate of ICU admission in patients with COVID-19 in this systematic review and Meta-Analysis might be due to a small number of studies assessing rates of admission compared to the number of cases and also the majority of studies were case series with small sample size.…”

“…The challenge of COVID-19 is very high globally due to a lack of proven treatment and the complexity of its transmission 13,[21][22][23][24][25][26][27] . However, it will be more catastrophic for low and middleincome countries because of very poor health care system, high illiteracy and low awareness of the disease and its prevention, lack of skilled health personnel, scarce Intensive Care Unit, a limited number of mechanical ventilators and prevalence of co-morbidities/infection along with malnutrition.…”

Characterization of Aerosols Generated During Patient Care Activities

“…Aerosol-generating procedures have also been suspected as a source of HCP infection in other outbreaks, such as 2009 H1N1 influenza [2,4,16], seasonal influenza [3,17,18], and MERS [19,20]. Some have also raised concerns that filoviruses, including Ebola, may be transmitted through aerosols, though this remains controversial [21].…”

Dynamics of scientific publications on the MERS-CoV outbreaks in Saudi Arabia

“…Effectiveness of consistent promotion and application of basic and advanced infection control procedures in reduction of cases has been demonstrated in hospital-associated MERS-CoV outbreaks in Saudi Arabia and Korea [53,85,91]. However, MERS-CoV has a high morbidity and case-fatality rate, particularly among ICU and/or critically ill patients, those with comorbid illness, older patients and those with a high viral load [11,12,15,[92][93][94]. The potential for viral mutations, for example in the viral spike (S) protein, which mediates viral entry into host cells, or in viral proteases such as Mpro, could increase viral affinity for human host cells and expand host cell range [50,[94][95][96].…”