Critically ill patients with chikungunya virus infection during the carribean outbreak 2013 - 2014

Thiéry, Guillaume; Crosby, Lori E.; Perreau, C; Madeux, Benjamin; Cossic, Jeanne; Armand, C.; Herrmann-Storcke, C; Najioullah, Fatiha; Valentino, Ruddy

doi:10.1186/2197-425x-3-s1-a348

Cited by 4 publications

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“…Many sources reported arrythmia in general, as well as palpitations [ 15 , 46 , 53 , 76 , 77 ] ( Table 2 and Table 3 ). Additional cardiac alterations included myocardial infarct, heart failure, cardiac arrest, and myocarditis [ 14 , 26 , 29 , 30 , 41 , 43 , 44 , 53 , 61 , 67 , 74 ] ( Table 2 and Table 3 ). In children (ages 1 year to 18 years), the symptoms were similar to that in adults with tachycardia, bradycardia, hypertensive shock, myocarditis, cardiorespiratory failure, and death being reported [ 2 , 34 , 38 , 50 , 52 , 66 , 72 ] ( Table 2 and Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…There are a number of cases in which the CHIKV infection may have aggravated a pre-existing heart condition, including hypertension, ischemic heart disease, cardiac compromise, and heart failure [ 37 , 41 , 44 , 55 , 61 , 70 , 71 , 74 , 79 , 80 ] ( Table 2 and Table 3 ). Additionally, those who are elderly, especially if they have cardiac alterations, were found to be at higher risk of death [ 81 ] ( Table 2 and Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…In three studies, patients who developed myocarditis, with or without pre-existing conditions, were at risk of death [ 44 , 52 , 57 ] ( Table 2 and Table 3 ). Five studies reported that when patients were admitted to hospitals, the mortality rate for CHIKV positive patients with severe conditions (including cardiac compromise) ranged from 26% to 48% [ 30 , 43 , 44 , 49 , 82 ] ( Table 2 and Table 3 ). In order to explore specific clinical features and their correlation with death, studies were divided into single patient case reports and clinical studies with multiple patients.…”

Section: Resultsmentioning

confidence: 99%

“…Of patients admitted to hospitals, the mortality rate for CHIKV positive patients with severe conditions (including cardiac compromise) ranges from 26% to 48% [ 30 , 43 , 44 , 49 , 82 ]. While there are few studies that thoroughly examine the number of CHIKV patients who present with cardiac complications (including the use of echocardiograms to verify arrythmias), Castillo et al estimates that 10% of their 32 patients exhibited heart complications [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

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Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome

et al. 2021

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Chikungunya virus (CHIKV) is vectored by Aedes aegypti and Aedes albopictus mosquitoes and is found throughout tropical and sub-tropical regions. While most infections cause mild symptoms such as fever and arthralgia, there have been cases in which cardiac involvement has been reported. In adults, case reports include symptoms ranging from tachycardia and arrythmia, to myocarditis and cardiac arrest. In children, case reports describe symptoms such as arrythmia, myocarditis, and heart failure. Case reports of perinatal and neonatal CHIKV infections have also described cardiovascular compromise, including myocardial hypertrophy, ventricular dysfunction, myocarditis, and death. Myocarditis refers to inflammation of the heart tissue, which can be caused by viral infection, thus becoming viral myocarditis. Since viral myocarditis is linked as a causative factor of other cardiomyopathies, including dilated cardiomyopathy, in which the heart muscle weakens and fails to pump blood properly, the connection between CHIKV and the heart is concerning. We searched Pubmed, Embase, LILACS, and Google Scholar to identify case reports of CHIKV infections where cardiac symptoms were reported. We utilized NCBI Virus and NCBI Nucleotide to explore the lineage/evolution of strains associated with these outbreaks. Statistical analysis was performed to identify which clinical features were associated with death. Phylogenetic analysis determined that CHIKV infections with cardiac symptoms are associated with the Asian, the East Central South African, and the Indian Ocean lineages. Of patients admitted to hospital, death rates ranged from 26–48%. Myocarditis, hypertension, pre-existing conditions, and the development of heart failure were significantly correlated with death. As such, clinicians should be aware in their treatment and follow-up of patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome

et al. 2021

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Chikungunya Fever

Chandrakanta,

Prajapati,

Sah

2024

Rising Contagious Diseases

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Chikungunya Encephalitis: an Inconsistently Reported Headache and Cause of Death in Patients with Pre-Existing Conditions

2022

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Chikungunya virus (CHIKV) is an alphavirus of the family Togaviridae with outbreaks occurring across Africa, Asia, parts of Europe, and South and Central America. There are three main lineages of CHIKV, including the West African lineage, the East Central South African (ECSA) lineage, and the Asian lineage. While CHIKV infection usually results in a self-limited febrile illness, there have been reports of concerning neurological manifestations, including encephalitis. Herein we discuss findings of over 700 cases of CHIKV encephalitis and risk factors for death. Additionally, we examined the genotypes of CHIKV associated with encephalitis and found that both the Asian and ECSA lineages were responsible for encephalitis but not the West African lineage. Protein analysis of consensus sequences of CHIKV strains associated with encephalitis identified mutations in the nsP1, nsP2, and nsP3 proteins. Reports and manuscripts of CHIKV encephalitis were inconsistent in reporting viral, demographic, and clinical features which complicated the delineation of risk factors associated with the disease and viral evolution. As climate change contributes to the range expansion of natural vectors, it is important for researchers and clinicians to consistently report patient and viral data to facilitate research and countermeasures for the ecology and epidemiology of CHIKV due to the lack of a targeted treatment or vaccine.

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Critically ill patients with chikungunya virus infection during the carribean outbreak 2013 - 2014

Cited by 4 publications

References 0 publications

Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome

Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome

Chikungunya Fever

Chikungunya Encephalitis: an Inconsistently Reported Headache and Cause of Death in Patients with Pre-Existing Conditions

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