Critically ill infants with SARS-COV-2 delta variant infection

Borgi, Aida; Louati, Assaad; Miraoui, Amal; Lahmar, L.; Ayari, Ahmed; Hajji, Ahmed; Bouziri, A.; Menif, Khaled; Smaoui, H.; JABALLAH, Nejla BEN.

doi:10.1016/j.pedneo.2022.09.014

Cited by 4 publications

(7 citation statements)

References 16 publications

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“…Therefore, the present study contributes to the evidence indicating that children can be affected by COVID-19 and may experience severe illness requiring hospitalization. The study by Borgi et al has previously described the clinical scenario of COVID-19 infection and hospitalization in the PICU from June 2021 to August 2021 in Tunisia [15]. The study had included only 20 patients with no comorbidities.…”

Section: Discussionmentioning

confidence: 99%

“…The patients admitted to the intensive care unit (ICU) during the period when the Delta variant was predominant were analyzed. However, this study had the limitation of a smaller sample size [15]. Furthermore, for the 17 months following the first case detection in March 2020, high variability in the SARS-CoV-2 lineage was reported in Tunisia [16].…”

Section: Introductionmentioning

confidence: 88%

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Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Borgi,

Meftah,

Trabelsi

et al. 2024

Viruses

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Due to low susceptibility of coronavirus disease of 2019 (COVID-19) in children, limited studies are available regarding COVID-19 in the pediatric population in Tunisia. The current study evaluated the incidence, clinical characteristics, and outcomes of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection among children hospitalized at Béchir Hamza Children’s Hospital. A retrospective cohort analysis was conducted using the hospital database between March 2020 and February 2022 with children aged ≤15 years with SARS-CoV-2 infection (confirmed by RT-PCR). A total of 327 COVID-19 hospitalized patients with a mean age of 3.3 years were included; the majority were male. Neurological disease (20%) was the most common comorbidity, while fever (95.3%) followed by cough (43.7%) and dyspnea (39.6%) were the most frequent symptoms reported. Severe disease with oxygen requirement occurred in 30% of the patients; 13% were admitted in the Intensive Care Unit. The overall incidence rate of COVID-19 hospitalization (in Tunis governorates) was 77.02 per 100,000 while the inpatient case fatality rate was 5% in the study population. The most prevalent circulating variant during our study period was Delta (48.8%), followed by Omicron (26%). More than 45% of the study population were <6 months and one-fourth (n = 25, 26.5%) had at least one comorbidity. Thus, the study findings highlight the high disease burden of COVID-19 in infants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Borgi,

Meftah,

Trabelsi

et al. 2024

Viruses

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“…Most publications on clinical experiences from African settings describe either case series or small cohorts of mostly asymptomatic children found through contact tracing [12–16]. Table 1 summarizes clinical data of four hospital-based studies in Africa, of which three are from Sub-Saharan Africa and one from North Africa (Tunisia) [8 ▪▪ ,17 ▪ ,18 ▪ ,19]. The Tunisian study only includes children admitted to the pediatric intensive care unit (PICU).…”

Section: Acute Coronavrus Disease 2019mentioning

confidence: 99%

Pediatric coronavirus disease 2019 in Africa

Zalm¹,

Donà²,

Rabie³

2023

Current Opinion in Pediatrics

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Purpose of reviewThree years into the coronavirus disease 2019 (COVID-19) pandemic, data on pediatric COVID-19 from African settings is limited. Understanding the impact of the pandemic in this setting with a high burden of communicable and noncommunicable diseases is critical to implementing effective interventions in public health programs.Recent findingsMore severe COVID-19 has been reported in African settings, with especially infants and children with underlying comorbidities at highest risk for more severe disease. Data on the role of tuberculosis and HIV remain sparse. Compared to better resourced settings more children with multisystem inflammatory disease (MISC) are younger than 5 years and there is higher morbidity in all settings and increased mortality in some settings. Several reports suggest decreasing prevalence and severity of MIS-C disease with subsequent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variant waves. Whether this decrease continues remains to be determined. Thus far, data on long-COVID in African settings is lacking and urgently needed considering the severity of the disease seen in the African population.SummaryConsidering the differences seen in the severity of disease and short-term outcomes, there is an urgent need to establish long-term outcomes in children with COVID-19 and MIS-C in African children, including lung health assessment.

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“…We have previously reported that neonates were more likely than older children to require respiratory support following SARS-CoV-2 infection when the wildtype variant was dominant,2 but it is not clear if this pattern persisted in later periods. The alpha and delta variants of SARS-CoV-2 resulted in more severe maternal SARS-CoV-2 infection,3 but there are few studies describing the impact of SARS-CoV-2 viral variants in neonates 4…”

Section: Introductionmentioning

confidence: 99%

“…The alpha and delta variants of SARS-CoV-2 resulted in more severe maternal SARS-CoV-2 infection, 3 but there are few studies describing the impact of SARS-CoV-2 viral variants in neonates. 4 …”

Section: Introductionmentioning

confidence: 99%

Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study

Gale,

Sharkey,

Fitzpatrick

et al. 2023

Arch Dis Child Fetal Neonatal Ed

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ObjectiveNeonatal infection with wildtype SARS-CoV-2 is rare and good outcomes predominate. We investigated neonatal outcomes using national population-level data to describe the impact of different SARS-CoV-2 variants.DesignProspective population-based cohort study.SettingNeonatal, paediatric and paediatric intensive care inpatient care settings in the UK.PatientsNeonates (first 28 days after birth) with confirmed SARS-CoV-2 infection who received inpatient care, March 2020 to April 2022. Neonates were identified through active national surveillance with linkage to national SARS-CoV-2 testing data, routinely recorded neonatal data, paediatric intensive care data and obstetric and perinatal mortality surveillance data.OutcomesPresenting signs, clinical course, severe disease requiring respiratory support are presented by the dominant SARS-CoV-2 variant in circulation at the time.Results344 neonates with SARS-CoV-2 infection received inpatient care; breakdown by dominant variant: 146 wildtype, 123 alpha, 57 delta and 18 omicron. Overall, 44.7% (153/342) neonates required respiratory support; short-term outcomes were good with 93.6% (322/344) of neonates discharged home. Eleven neonates died: seven unrelated to SARS-CoV-2 infection, four were attributed to neonatal SARS-CoV-2 infection (case fatality 4/344, 1.2% 95% CI 0.3% to 3.0%) of which three were born preterm due to maternal COVID-19. More neonates were born very preterm (23/54) and required invasive ventilation (27/57) when delta variant was predominant, and all four SARS-CoV-2-related deaths occurred in this period.ConclusionsInpatient care for neonates with SARS-CoV-2 was uncommon. Although rare, severe neonatal illness was more common during the delta variant period, potentially reflecting more severe maternal disease and associated preterm birth.Trial registration numberISRCTN60033461.

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Critically ill infants with SARS-COV-2 delta variant infection

Cited by 4 publications

References 16 publications

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Retrospective Analysis of Clinical Characteristics and Disease Outcomes in Children and Adolescents Hospitalized Due to COVID-19 Infection in Tunisia

Pediatric coronavirus disease 2019 in Africa

Characteristics and outcomes of neonates hospitalised with SARS-CoV-2 infection in the UK by variant: a prospective national cohort study

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