Critical tissue copper residues for marine bivalve (Mytilus galloprovincialis) and echinoderm (Strongylocentrotus purpuratus) embryonic development: Conceptual, regulatory and environmental implications

Rosen, Gunther; Rivera-Duarte, Ignacio; Chadwick, D. B.; Ryan, Adam C.; Santore, Robert C.; Paquin, Paul

doi:10.1016/j.marenvres.2008.05.006

Cited by 46 publications

(44 citation statements)

References 47 publications

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“…Copper is highly toxic for sea urchin embryos (King & Riddle, 2001;Kobayashi & Okamura, 2004;Rosen et al, 2008). In Lytechinus pictus embryos, we obtained an EC 50 of 32 ppb of copper for CuSO 4 , which is similar to the value reported for Paracentrotus lividus (67 ppb of copper, Fernández & Beiras, 2001).…”

Section: Discussionsupporting

confidence: 87%

Developmental effects of two different copper oxide nanomaterials in sea urchin (Lytechinus pictus) embryos

et al. 2015

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Copper oxide nanomaterials (nano-CuOs) are widely used and can be inadvertently introduced into estuarine and marine environments. We analyzed the effects of different nano-CuOs (a synthesized and a less-pure commercial form), as well as ionic copper (CuSO 4 ) on embryo development in the white sea urchin, a well-known marine model. After 96 h of development with both nano-CuO exposures, we did not detect significant oxidative damage to proteins but did detect decreases in total antioxidant capacity. We show that the physicochemical characteristics of the two nano-CuOs play an essential role in their toxicities. Both nano-CuOs were internalized by embryos and their differential dissolution was the most important toxicological parameter. The synthesized nano-CuO showed greater toxicity (EC 50 ¼ 450 ppb of copper) and had increased dissolution (2.5% by weight over 96 h) as compared with the lesspure commercial nano-CuO (EC 50 ¼ 5395 ppb of copper, 0.73% dissolution by weight over 96 h). Copper caused specific developmental abnormalities in sea urchin embryos including disruption of the aboral-oral axis as a result in changes to the redox environment caused by dissolution of internalized nano-CuO. Abnormal skeleton formation also occurred.

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Section: Discussionsupporting

confidence: 87%

Developmental effects of two different copper oxide nanomaterials in sea urchin (Lytechinus pictus) embryos

et al. 2015

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“…They are constantly exposed to a number of pollutants (Bellas et al, 2008a;Rosen et al, 2008). Sea urchins have been adopted as an excellent model system to study the ecotoxicological response of marine invertebrates to environmental pollutants (Geraci et al, 2004;Bonaventura et al, 2005;Cakal Arslan and Parlak, 2007;Bellas et al, 2008b;Nahon et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7

et al. 2016

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a b s t r a c tDiatoms are an important class of unicellular algae that produce bioactive secondary metabolites with cytotoxic activity collectively termed oxylipins, including polyunsaturated aldehydes (PUAs), hydroxyacids (HEPEs), oxo-acids and epoxyalcohols. Previous results showed that at higher concentrations, the PUA decadienal induced apoptosis on copepods and sea urchin embryos via caspase-3 activation; at lower concentrations decadienal affected the expression levels of the caspase-8 gene in embryos of the sea urchin Paracentrotus lividus. In the present work, we studied the effects of other common oxylipins produced by diatoms: two PUAs (heptadienal and octadienal) and four hydroxyacids (5-, 9-11-and 15-HEPE) on P. lividus cell death and caspase activities. Our results showed that (i) at higher concentrations PUAs and HEPEs induced apoptosis in sea urchin embryos, detected by microscopic observation and through the activation of caspase-3/7 and caspase-8 measured by luminescent assays; (ii) at low concentrations, PUAs and HEPEs affected the expression levels of caspase-8 and caspase-3/7 (isolated for the first time here in P. lividus) genes, detected by Real Time qPCR. These findings have interesting implications from the ecological point of view, given the importance of diatom blooms in nutrient-rich aquatic environments.

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“…Sensitivity of copper to this genus, therefore, is similar to other common sea urchins, such as S. purpuratus (14.3 to 15.3 µg/L; Phillips et al, 2003;Rosen et al, 2008) and P. lividus (62 µg/L; Novelli et al, 2003). Although these concentrations are relatively low in the copper species sensitivity distribution (SSD) (USEPA, 1995a), the presence of similar species and sensitivities of existing copper criteria suggest that Diadema spp.…”

Section: Discussionmentioning

confidence: 63%

“…This approach is similar to successfully executed projects for copper at U.S. Navy installations in Pearl Harbor, HI (Earley et al, 2007) and Sinclair and Dyes Inlets, Puget Sound, WA (Rosen et al, 2009). It incorporates various aspects of the latest state of the science Rosen et al, 2005Rosen et al, , 2008Chadwick et al, 2008;Earley et al, 2010). The ultimate goal of the study design was to provide scientific information supporting site-specific discharge limits using USEPA approved procedures, including (1) a chemical translator for copper and nickel, (2) an assessment of the applicability of the Recalculation Procedure, (3) Water Effect Ratio (WER), and (4) a mixing zone analysis of the discharge environment.…”

Section: Introductionmentioning

confidence: 99%

Development of Site-Specific Water Quality Criteria for the Arpa Harbor Wastewater Treatment Plant in Tipalao Bay, Guam

Earley¹,

Rosen²,

Rivera-Duarte³

et al. 2016

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Critical tissue copper residues for marine bivalve (Mytilus galloprovincialis) and echinoderm (Strongylocentrotus purpuratus) embryonic development: Conceptual, regulatory and environmental implications

Cited by 46 publications

References 47 publications

Developmental effects of two different copper oxide nanomaterials in sea urchin (Lytechinus pictus) embryos

Developmental effects of two different copper oxide nanomaterials in sea urchin (Lytechinus pictus) embryos

Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7

Development of Site-Specific Water Quality Criteria for the Arpa Harbor Wastewater Treatment Plant in Tipalao Bay, Guam

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