Critical size defects for bone regeneration experiments in rabbit calvariae: systematic review and quality evaluation using <scp>ARRIVE</scp> guidelines

Delgado-Ruíz, Rafael Arcesio; Calvo-Guirado, José Luís; Romanos, Georgios E.

doi:10.1111/clr.12406

Cited by 60 publications

(56 citation statements)

References 69 publications

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“…The red number at the bottom of each column represents the total score for all manuscripts for each category; bold black letters at the bottom of each column show the maximum possible value for each category size, allocation, numbers analyzed, adverse effects, general applicability/relevance and funding. This also agrees with Schwarz et al (2012), Delgado-Ruiz et al (2014) and Vajgel et al (2014).…”

Section: Quality Assessment Using Arrive Guidelinessupporting

confidence: 88%

“…The manuscripts included for review were evaluated applying the ARRIVE guidelines for assessing in vivo animal experiments Schwarz et al 2012;Vajgel et al 2014) scoring the following items: To assess the quality of a study, each item received a grade following the procedure described by and Schwarz et al (2012); awarding each manuscript with a maximum possible score (MPS) as described by Delgado-Ruiz et al (2014) ( Table 1).…”

Section: Quality Assessmentmentioning

confidence: 99%

“…As a result, statistical comparison of the studies was not possible, a situation that agrees with Schwarz et al (2012) who identified wide variations between studies of this type which often failed to provide information in different areas. Delgado-Ruiz et al (2014) performed another systematic review of CSD healing in rabbit calvariae (empty defects) that also noted high variability and missing data.…”

Section: Quality Assessment Using Arrive Guidelinesmentioning

confidence: 99%

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Bone grafting materials in critical defects in rabbit calvariae. A systematic review and quality evaluation using ARRIVE guidelines

Delgado-Ruíz

Calvo-Guirado

Romanos

2015

Clinical Oral Implants Res

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Autogenous bone grafts increase NB. DC is enhanced by the use of fragmented adipose tissue. RG remains in the defect for longer when hydroxyapatite/beta-tricalcium phosphate with silica is used, and more CT can be expected when hydroxyapatite/beta-tricalcium phosphate with silica grafts are covered by a membrane. The addition of stem cells of different origins to grafting materials enhances bone formation in early healing periods. The ARRIVE guidelines are still insufficiently used and the overall quality of studies remains low.

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Section: Quality Assessment Using Arrive Guidelinessupporting

confidence: 88%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Quality Assessment Using Arrive Guidelinesmentioning

confidence: 99%

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Bone grafting materials in critical defects in rabbit calvariae. A systematic review and quality evaluation using ARRIVE guidelines

Delgado-Ruíz

Calvo-Guirado

Romanos

2015

Clinical Oral Implants Res

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“…The lack of an inverse relationship between marrow area and post‐ablation intramembranous bone volume was unexpected given that defect size is known to influence bone repair and that larger defects heal less well than smaller defects . The lack of correlation with ear punch healing was also unexpected because of the association between ear and cartilage healing recently reported .…”

Section: Discussionmentioning

confidence: 99%

“…Femurs were embedded in methylmethacrylate and cut in the coronal plane on a Leica RM2255 microtome to create alternating 4 and 8 μm thick sections . The 4 μm sections were stained using Von Kossa for mineralized tissue and counterstained with tetrachrome for soft tissues . In Experiment 2, calcein (15 mg/kg) was administered subcutaneously to all animals on days 5 and 2 prior to sacrifice.…”

Section: Methodsmentioning

confidence: 99%

Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation

Moran

Virdi

Sena

et al. 2015

Journal Orthopaedic Research

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Various intact and post-injury bone phenotypes are heritable traits. In this study, we sought to determine if intramembranous bone regeneration following marrow ablation differed among common inbred mouse strains and to identify how early the differences appear. We found a $four-fold difference in the regenerated bone volume 21 days after marrow ablation in females from four inbred mouse strains: FVB/N (15.7 AE 8.1%, mean and standard deviation), C3H/He (15.5 AE 4.2%), C57BL/6 (12.2 AE 5.2%), and BALB/c (4.0 AE 4.4%); with BALB/c different from FVB/N (p ¼ 0.007) and C3H/He (p ¼ 0.002). A second experiment showed that FVB/N compared to BALB/c mice had more regenerated bone 7 and 14 days after ablation (p < 0.001), while at 21 days FVB/N mice had a greater fraction of mineralizing surface (p ¼ 0.008) without a difference in mineral apposition rate. Thus, differences among strains are evident early during intramembranous bone regeneration following marrow ablation and appear to be associated with differences in osteogenic cell recruitment, but not osteoblast activity. The amount of regenerating bone was not correlated with other heritable traits such as the intact bone phenotype or soft tissue wound healing, suggesting that there may be independent genetic pathways for these traits. ß

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Surgical lymphedema models in the mice hindlimb—A systematic review and quality assessment

Bucan,

Frendø,

Ngo

et al. 2023

Microsurgery

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BackgroundLymphedema constitutes a major unsolved problem in plastic surgery. To identify novel lymphedema treatments, preclinical studies are vital. The surgical mouse lymphedema model is popular and cost‐effective; nonetheless, a synthesis and overview of the literature with evidence‐based guidelines is needed. The aim of this review was to perform a systematic review to establish best practice and support future high‐quality animal studies exploring lymphedema treatments.MethodsWe performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, searching four databases (PubMed, Embase, Web of Science, and Scopus) from inception–September 2022. The Animals in Research Reporting In Vivo Experiments 2.0 (ARRIVE 2.0) guidelines were used to evaluate reporting quality. Studies claiming to surgically induce lymphedema in the hindlimb of mice were included.ResultsThirty‐seven studies were included. Four main models were used. (1) Irradiation+surgery. (2) A variation of the surgery used by (1) + irradiation. (3) Surgery only (SPDF‐model). (4) Surgery only (PLND‐model). Remaining studies used other techniques. The most common measurement modality was the caliper. Mean quality coefficient was 0.57. Eighteen studies (49%) successfully induced sustained lymphedema. Combination of methods seemed to yield the best results, with an overrepresentation of irradiation, the removal of two lymph nodes, and the disruption of both the deep and superficial lymph vessels in the 18 studies.ConclusionSurgical mouse hindlimb lymphedema models are challenged by two related problems: (1) retaining lymphedema for an extended period, that is, establishing a (chronic) lymphedema model (2) distinguishing lymphedema from post‐operative edema.Most studies failed to induce lymphedema and used error‐prone measurements. We provide an overview of studies claiming to induce lymphedema and advocate improved research via five evidence‐based recommendations to use: (1) a proven lymphedema model; (2) sufficient follow‐up time, (3) validated measurement methods; (4) ARRIVE‐guidelines; (5) contralateral hindlimb as control.

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Critical size defects for bone regeneration experiments in rabbit calvariae: systematic review and quality evaluation using ARRIVE guidelines

Cited by 60 publications

References 69 publications

Bone grafting materials in critical defects in rabbit calvariae. A systematic review and quality evaluation using ARRIVE guidelines

Bone grafting materials in critical defects in rabbit calvariae. A systematic review and quality evaluation using ARRIVE guidelines

Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation

Surgical lymphedema models in the mice hindlimb—A systematic review and quality assessment

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