Critical roles of periostin in the process of orthodontic tooth movement

Rangiani, Afsaneh; Jing, Yan; Ren, Yinshi; Yadav, Sumit; Taylor, Reginald W.; Feng, Jian Q.

doi:10.1093/ejo/cjv071

Cited by 29 publications

(38 citation statements)

References 26 publications

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“…In this study, the change patterns of sclerostin expression in the compression and tension sites during tooth movement were different. Our result was partially in agreement with a study by Rangiani’ [36], who reported an increase in SOST expression at the compression site and a reduction in expression at the tension site 8 days after orthodontic force loading in a tooth movement model in mice. The different expression pattern of sclerostin in compression and tension sites during tooth movement was a novel finding, which indicated that additional research on the biological function of sclerostin in toothmovement is needed.…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, explaining sclerostin expression and the role of sclerostin in tooth movement bone remodeling was necessary. Two recently published papers investigated sclerostin expression in tooth movement models [35, 36]; however, the researchers only studied the expression of sclerostin at a single time point. To our knowledge, this study is the first one to trace the expression pattern of sclerostin throughout an entire orthodontic cycle (four weeks) in rats.…”

Section: Discussionmentioning

confidence: 99%

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Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement

et al. 2017

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Tooth movement is a biological process of bone remodeling induced by mechanical force. Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling. However, little is known regarding the role of sclerostin in tooth movement. In this study, models of experimental tooth movement were established in rats and mice. Sclerostin expression was investigated with immunohistochemistry staining, and osteoclastic activity was analyzed with tartrate-resistant acid phosphatase (TRAP) staining. MLO-Y4 osteocyte-like cells underwent uniaxial compression and tension stress or were cultured in hypoxia conditions. Expression of sclerostin was assessed by RT-qPCR and ELISA. MLO-Y4 cells were cultured with recombinant human sclerostin (rhSCL) interference and then co-cultured with RAW264.7 osteoclast precursor cells. Expressions of RANKL and OPG were analyzed by RT-qPCR, and osteoclastic activity was assessed by TRAP staining. During tooth movement, sclerostin was expressed differently in compression and tension sites. In SOST knock-out mice, there were significantly fewer TRAP-positive cells than in WT mice during tooth movement in compression sites. In-vitro studies showed that the expression of sclerostin in MLO-Y4 osteocyte-like cells was not different under a uniaxial compression and tension force, whereas hypoxia conditions significantly increased sclerostin expression in MLO-Y4 cells. rhSCL interference increased the expression of RANKL and the RANKL/OPG ratio in MLO-Y4 cells and the osteoclastic induction ability of MLO-Y4 cells in experimental osteocyte-osteoclast co-culture. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement

et al. 2017

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“…Periostin has been shown to contribute to bone and periodontal tissue remodeling following mechanical stress in experimental models of tooth movement, and is closely related to mechanical sensing (Wilde et al, 2003;Kudo, 2011;Rangiani et al, 2016). The presence of periostin not only affects the composition of ECM, but also alters the physical properties of the ECM such as matrix stiffness that influence stem cell behavior (Guilak et al, 2009;Lv et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Periostin plays role in force‐induced stem cell potential by periodontal ligament stem cells

Panchamanon

Pavasant

Leethanakul

2019

Cell Biology International

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Mechanical stimuli have been shown to play an important role in directing stem cell fate and maintenance of tissue homeostasis. One of the functions of the mechanoresponsive tissue periodontal ligament (PDL) is to withstand the functional forces within the oral cavity. Periodontal ligament stem cells (PDLSCs) derived from periodontal tissue have been demonstrated to be able to respond directly to mechanical forces. However, the mechanisms of action of mechanical force on PDLSCs are not totally understood. The aim of this study was to investigate the mechanisms by which compressive force affects PDLSCs, especially their stemness properties. PDLSCs were established from extracted human third molars; their stem cell characteristics were validated by detecting the expression of stem cell markers and confirming their ability to differentiate into osteogenic and adipogenic lineages. PDLSCs were subjected to various magnitudes of static compressive force (0 [control], 0.5, 1.0, 1.5, or 2 g/cm 2 ). Application of 1.0 g/cm 2 compressive force significantly upregulated a panel of stem cell marker genes, including NANOG and OCT4. Conversely, higher force magnitudes downregulated these genes. Mechanical loading also upregulated periostin, a matrix protein that plays important roles in tissue morphogenesis. Interestingly, knockdown of periostin using siRNA abolished force-induced stem cell marker expression in PDLSCs. This study suggests a proper magnitude of compressive force could be one important factor involved in the modulation of the pluripotency of PDLSCs through the action of periostin. The precise mechanism by which periostin regulates stemness requires further detailed investigation.Periostin in force-induced PDLSC potential P. Panchamanon et al. 2Periostin in force-induced PDLSC potential P. Panchamanon et al. 4Periostin in force-induced PDLSC potential P. Panchamanon et al.

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“…There are two areas that Postn has been examined in 1) periodontal surgery (Padial-Molina, et al, 2015) and 2) experimental tooth movement (Rangiani, et al, 2015, Wilde, et al, 2003). Using an observational prospective case-control study Padial-Molina and colleagues assessed Postn expression in patients with and without periodontitis.…”

Section: Periodontiummentioning

confidence: 99%

“…During experimental tooth movement, Postn expression has been shown to be upregulated in the compression sites compared to tension sites of the PDL following experimental tooth movement in mice (Wilde, et al, 2003). In a subsequent study by Rangiani and colleagues, they assessed experimental tooth movement, comparing the process directly in Postn −/− and Postn +/+ mice (Rangiani, et al, 2015). Interestingly, the process of tooth movement was significantly slower in Postn −/− mice compared to wild types, and this was concomitant with no change in sclerostin expression, but reduced numbers of osteoclasts and the integrity of collagen fibers was also significantly compromised.…”

Section: Periodontiummentioning

confidence: 99%

Periostin as a multifunctional modulator of the wound healing response

et al. 2016

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During tissue healing, dynamic and temporal alterations occur in the structure and composition of the extracellular matrix (ECM) that are required for effective repair to occur. Matricellular proteins (MPs) are a group of diverse non-structural ECM components, which bind cell surface receptors mediating interactions between the cell and its microenviroment, effectively regulating adhesion, migration, proliferation, signaling and cell phenotype. Periostin (Postn), a pro-fibrogenic secreted glycoprotein, was defined as a MP based on its expression pattern and regulatory roles during development, healing and in disease processes. Postn consists of a typical signal sequence, an EMI domain responsible for binding to fibronectin, four tandem fasciclin-like domains that are responsible for integrin binding and a C-terminal region where multiple splice variants originate. This review will focus specifically on the role of Postn in wound healing and remodeling, an area of intense research in the last 10 years particularly related to skin healing as well as in myocardium post infarction. Postn interacts with cells through various integrin pairs and is an essential downstream effector of TGF-β superfamily signaling. As will be discussed, across different tissues, Postn is associated with pro-fibrogenic process, specifically, the transition of fibroblasts to myofibroblasts, collagen fibrillogenesis and ECM synthesis. Although the complexity of Postn as a modulator of cell behavior in tissue healing is only beginning to be elucidated, its expression is clearly a defining event in moving wound healing through the proliferative and remodeling phases.

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Critical roles of periostin in the process of orthodontic tooth movement

Cited by 29 publications

References 26 publications

Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement

Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement

Periostin plays role in force‐induced stem cell potential by periodontal ligament stem cells

Periostin as a multifunctional modulator of the wound healing response

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