Critical Role of Oxalate Restriction in Association with Calcium Restriction to Decrease the Probability of Being a Stone Former: Insufficient Effect in Idiopathic Hypercalciuria

Abstract

The probability of being a stone former (PSF) was calculated in 3 groups of idiopathic calcium stone formers [with normocalciuria (NC), dietary hypercalciuria (DH) and idiopathic hypercalciuria (IH)] in 4 conditions: while (1) on a free diet; (2) on a calcium- and oxalate-restricted diet during 4 days; (3) after an oxalate load, while on a 1.5-gram calcium diet, and (4) after an oxalate load while on a calcium-restricted diet. Combined calcium and oxalate restriction significantly decreased PSF only in NC and DH whereas the decrease was not significant in IH because of a concomitant significant increase in oxalate excretion. Increase of PSF with the oxalate load was significantly greater during a calcium-restricted diet than during the 1.5-gram calcium diet in all groups of patients (4,6 and 12 times greater in NC, DH and IH, respectively). These data show the critical role of oxalate restriction when calcium is restricted in order to decrease the PSF. This combined restriction is however not sufficient in idiopathic hypercalciuric patients to decrease their PSF.

Role of the insulin-like growth factor system in epiphyseal cartilage on the development of Langshan and Arbor Acres chickens, Gallus domesticus

“…Intake of a moderately high-calcium diet appears to be beneficial to decrease the urinary oxalate excretion and IGFBP-7 in patients with idiopathic hypercalciuria (Nakada et al, 1988). Increase of IGFBP-7 with the oxalate load was significantly greater on calcium-restricted than on calcium-unrestricted diets in all groups of patients (Bataille et al, 1983). We found that IGFBP-7 mRNA expression was higher in LL chickens than in AA chickens, and a strain difference was observed in IGFBP-7 expression between LA and LL chickens (Table 6).…”