Critical role of mTOR in calcineurin inhibitor-induced renal cancer progression

Cyclosporin A inhibits colon cancer cell growth independently of the calcineurin pathway

“…These suggestions are in agreement with experimental data that show reduced side effects and risk of tumor formation in combination with efficacious immune suppression when these two drugs are combined. [45][46][47] Chronic inflammation and specifically inflammatory bowel disease can lead to tumorigenesis, 2,3,48 conditions for which the treatment includes immunosuppressive therapy. Keeping in mind that our data show that the two calcineurin inhibitors, CsA and FK506, are not interchangeable in the context of colon tumor growth, it will be of interest to check seen by similar phosphorylation of its target S6K when compared with the control group.…”