Abstract:Our previous studies have shown that prostacyclin (PGI2) plays an important role in regulating mucosal inflammatory responses and the development of IL-17-producing innate T cells. Using mice lacking the PGI2 receptor, IP, we have investigated the role of this prostanoid in innate immune responses in the intestine. IL-22 belongs to the IL-10 family of cytokines and targets innate immune pathways due to the restricted expression of IL-22 receptors on innate cells critical to maintaining barrier function, such a… Show more
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