Critical Review—Recent Progress in NIR Fluorophores Emitting over 1000 nm for Bioimaging

Jin, Takashi

doi:10.1149/2.0111901jss

Cited by 24 publications

(23 citation statements)

References 79 publications

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“…Only recently, Antaris et al described the synthesis of the biocompatible and renally cleared NIR-II organic fluorophore CH1055 (Figure 1A) and its use for targeted tumor imaging after conjugation with an anti-Epidermal Growth Factor Receptor (EGFR) affibody-molecule (Antaris et al, 2016). This field may gain more traction in the near future (Jin, 2019).…”

Section: Molecular-targeted Fluorescent Tracersmentioning

confidence: 99%

Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making

Debie

Hernot

2019

Front. Pharmacol.

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Fluorescence imaging is an emerging technology that can provide real-time information about the operating field during cancer surgery. Non-specific fluorescent agents, used for the assessment of blood flow and sentinel lymph node detection, have so far dominated this field. However, over the last decade, several clinical studies have demonstrated the great potential of targeted fluorescent tracers to visualize tumor lesions in a more specific way. This has led to an exponential growth in the development of novel molecular fluorescent contrast agents. In this review, the design of fluorescent molecular tracers will be discussed, with particular attention for agents and approaches that are of interest for clinical translation.

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Section: Molecular-targeted Fluorescent Tracersmentioning

confidence: 99%

Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making

Debie

Hernot

2019

Front. Pharmacol.

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“…Although FI is one of the most widely explored tumor imaging modalities, which also offers the advantages of ease of operation, high sensitivity, and multicolor imaging capabilities, its applications are limited owing to its low depth of light penetration in tissues and poor S/N ratio (Guo et al, 2014;Jin, 2019). The poor S/N in FI is attributed to the non-specific distribution of the imaging probe in tissues and background autofluorescence.…”

Section: Ph-responsive Fimentioning

confidence: 99%

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Kumar

Park

2020

Front. Bioeng. Biotechnol.

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Polymeric nanobiosensors (PNBS) that respond to tumor-related factors, including pH, have shown great potential for disease detection owing to their selectivity and sensitivity. PNBS can be converted into theranostic polymeric nanobiosensors (TPNBS) by incorporating therapeutic cargo, thereby enabling concomitant diagnoses and therapy of targeted diseases. The polymeric compartments in TPNBS play a significant role in the development and therapeutic efficacy of nanobiosensors. Polymers enhance the stability, biocompatibility, and selective or effective accumulation of nanobiosensors at desired pathological sites. The intrinsic pH sensitivity of either the polymers in TPNBS or the TPNBS themselves provides integrated potentialities such as cogent accumulation of TPNBS at the tumor, augmented tumor penetration, cellular uptake, and theranostic activation, including enhanced bioimaging signals and controlled release of therapeutics. In this review, we summarize recent developments in the design, preparation, and characterization of pH-responsive TPNBS and their ability to behave as efficient in vivo nanotheranostic agents in acidic cancer environments.

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“…In which, polymethine dyes are a large class of compounds currently commercially available. This class of probes has a wide range of applications from lasers to diagnostic, as sensitizers for photodynamic therapy [34]. The molecular structure of these dyes is characterized by a conjugated (polymethine) chain terminated at each end by a heterocyclic moiety [35].…”

Section: Nir Molecular Probesmentioning

confidence: 99%

Development of Molecular Imaging Probe for Dual NIR/MR Imaging

Dung

Umezawa

Nigoghossian

et al. 2020

J. Photopol. Sci. Technol.

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Imaging utilizing the near-infrared (NIR) light has attracted numerous attention due to the possibility in the deep tissue penetration as it can overcome the light scattering and absorption of tissue components. The ultraviolet (UV) unlikely penetrates the skin, while the visible (VIS) light can be scattered or absorbed by tissue components. This penetration likely improves as the wavelength shifts beyond 1000 nm region (also called NIR-II). Fat tissues are ascribed to the scattering of UV or VIS, while others such as water, melanin, hemoglobin are greatly attributed to absorbing light. Using NIR over 1000 nm (OTN-NIR) is currently considered as a critical approach for real-time dynamical visualization of the structure and functional features of tissues anatomically with refrained effects of fatty scattering and water absorption. However, the attempts to image anatomical structure by OTN-NIR is laborious and time-consuming. Then, for facile human applying, magnetic resonance imaging (MRI) is used as a guiding technique to localize the sites of interest. MRI is considered the most beneficial imaging technique without ionizing radiation which provides images with high resolution, preeminent tissue contrast. MRI also can visualize a large volume such as the human body to the few millimeter objects with great signal-to-noise ratio as well as contrastto-noise ratio. This review highlights the design of imaging probe for multimodal NIR/MR imaging, including the potential applications.

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Critical Review—Recent Progress in NIR Fluorophores Emitting over 1000 nm for Bioimaging

Cited by 24 publications

References 79 publications

Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making

Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making

Recent Developments in Pathological pH-Responsive Polymeric Nanobiosensors for Cancer Theranostics

Development of Molecular Imaging Probe for Dual NIR/MR Imaging

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