Critical review on anthocyanins in blue honeysuckle (Lonicera caerulea L.) and their function

Guo, Liangchuan; Qiao, Jinli; Zhang, Lijun; Yan, Weijiao; Zhang, Meihui; Lu, Yongchuan; Wang, Yutong; Ma, Hexi; Liu, Yan; Zhang, Yue; Li, Jichuan; Qin, Dong; Huo, Junwei

doi:10.1016/j.plaphy.2023.108090

Cited by 8 publications

(2 citation statements)

References 61 publications

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“…A high content of polyphenolic compounds in Lonicera fruits was also reported by other authors [10,11]. Some of the health-promoting activities of Lonicera fruit consumption have also been attributed to its anthocyanin content [12,13]. In addition to having antioxidant and anti-inflammatory activities, anthocyanins have a broad spectrum of colors, making this class of compounds a potential replacement for synthetic dyes used in most industries (food, textile and cosmetics).…”

Section: Introductionsupporting

confidence: 57%

Bioactive Compounds in the Residue Obtained from Fruits of Some Cultivars of Lonicera caerulea

Cosmulescu,

Vijan,

Mazilu

et al. 2024

Horticulturae

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This paper aimed to investigate the bioactive compounds in the dry powder residue of honeysuckle cultivars after extracting the juice. Based on the analyses performed on the total content of phenolic compounds, flavonoids, anthocyanins, tannins, carotenoids and vitamin C, the results indicated that dried Lonicera caerulea residue represented a rich source of phenolic compounds (8041.36 mg GAE 100 g−1), of which about 80% were tannins (6432.10 mg GAE 100 g−1). The flavonoid content varied around 2436.95 mg CE 100 g−1. Vitamin C (185 mg 100 g−1), lycopene and β-carotene (over 2.5 and 2.8 mg 100 g−1, respectively) were also quantified. Among the phenolic acids, chlorogenic acid predominated (316 mg 100 g−1), followed by cryptochlorogenic acid (135 mg 100 g−1) and neochlorogenic acid (32 mg 100 g−1). Flavonoids were mainly represented by catechin (2594 mg 100 g−1) and anthocyanins (1442 mg 100 g−1). Similar amounts of epicatechin and rutin were measured (156 mg 100 g−1 and 148 mg 100 g−1), while the isoquercetin concentration was below 15 mg 100 g−1. In conclusion, the high level of phytocompounds and the diverse composition of dry Lonicera caerulea residue support its high nutraceutical value and high health-promoting potential.

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Section: Introductionsupporting

confidence: 57%

Bioactive Compounds in the Residue Obtained from Fruits of Some Cultivars of Lonicera caerulea

Cosmulescu,

Vijan,

Mazilu

et al. 2024

Horticulturae

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“…The scientific literature recognizes that LCF extract has anti-diabetic properties by inhibiting the enzyme activities of α -amylase, α -glucosidase, and dipeptidyl peptidase-4, the intensity of their pharmacological actions depending on the cultivar type and harvesting date. Additionally, it may also prevent the production of late glycosylation end products [ 9 , 102 , 103 ]. Moreover, another study has shown that the antidiabetic effects of LC berries vary depending on the form in which they are utilized, such as powdered fruit, pomace, juice, and sugar-free juice products (SFJP).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.

Bora,

Lombrea,

Batrina

et al. 2024

Antioxidants

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In the light of growing concerns faced by Western societies due to aging, natality decline, and epidemic of cardio-metabolic diseases, both preventable and treatable, new and effective strategical interventions are urgently needed in order to decrease their socio-economical encumbrance. The recent focus of research has been redirected towards investigating the potential of haskap (Lonicera caerulea L.) as a novel functional food or superfruit. Therefore, our present review aims to highlight the latest scientific proofs regarding the potential of Lonicera caerulea L. (LC), a perennial fruit-bearing plant rich in polyphenols, in reversing cardio-metabolic dysfunctions. In this regard, a systematic search on two databases (PubMed and Google Scholar) from 1 January 2016 to 1 December 2023 was performed, the keyword combination being Lonicera caerulea L. AND the searched pharmacological action, with the inclusion criteria consisting of in extenso original articles, written in English. The health-enhancing characteristics of haskap berries have been examined through in vitro and in vivo studies from the 35 included original papers. Positive effects regarding cardiovascular diseases and metabolic syndrome have been assigned to the antioxidant activity, hypolipidemic and hypoglycemic effects, as well as to the hepatoprotective and vasoprotective potential. Latest advances regarding LCF mechanisms of action are detailed within this review as well. All these cutting-edge data suggest that this vegetal product would be a good candidate for further clinical studies.

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The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

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Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical forms, such as tablets and capsules, only partially overcome these limitations, restricting their efficacy. With the recent development of nanotechnology, nanocarriers can enhance the bioavailability, stability, and precise intracellular transport of plant bioactive compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into the development of natural plant compounds with significant success. Moreover, natural products benefit from nanotechnological enhancement and contribute to the innovation and optimization of nanocarriers via self‐assembly, grafting modifications, and biomimetic designs. This review aims to elucidate the collaborative and reciprocal advancement achieved by integrating nanocarriers with botanical products, such as bioactive compounds, polysaccharides, proteins, and extracellular vesicles. This review underscores the salient challenges in nanomedicine, encompassing long‐term safety evaluations of nanomedicine formulations, precise targeting mechanisms, biodistribution complexities, and hurdles in clinical translation. Further, this study provides new perspectives to leverage nanotechnology in promoting the development and optimization of natural plant products for nanomedical applications and guiding the progression of NDDS toward enhanced efficiency, precision, and safety.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Critical review on anthocyanins in blue honeysuckle (Lonicera caerulea L.) and their function

Cited by 8 publications

References 61 publications

Bioactive Compounds in the Residue Obtained from Fruits of Some Cultivars of Lonicera caerulea

Bioactive Compounds in the Residue Obtained from Fruits of Some Cultivars of Lonicera caerulea

A Systematic Review of Cardio-Metabolic Properties of Lonicera caerulea L.

The development of nanocarriers for natural products

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