Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field

Cailletaud, Johan; Bleye, Charlotte De; Netchacovitch, Lauranne; Gut, Yoann; Boiret, Mathieu; Ginot, Yves‐Michel; Hubert, Ph.; Ziémons, Eric

doi:10.1016/j.jpba.2017.06.056

Cited by 81 publications

(38 citation statements)

References 101 publications

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“…Cailletaud et al described recent advances in the applications of SERS in pharmaceutical analysis [19]. In the present review, we will summarize the developments of SERS utilized in the field of analysis, focusing on three aspects, including DNA, protein and drug detection.…”

Section: Introductionmentioning

confidence: 99%

Novel Surface-Enhanced Raman Spectroscopy Techniques for DNA, Protein and Drug Detection

Chen

Liu

Tian

et al. 2019

Sensors

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Surface-enhanced Raman spectroscopy (SERS) is a vibrational spectroscopic technique in which the Raman scattering signal strength of molecules, absorbed by rough metals or the surface of nanoparticles, experiences an exponential growth (103–106 times and even 1014–1015 times) because of electromagnetic or chemical enhancements. Nowadays, SERS has attracted tremendous attention in the field of analytical chemistry due to its specific advantages, including high selectivity, rich informative spectral properties, nondestructive testing, and the prominent multiplexing capabilities of Raman spectroscopy. In this review, we present the applications of state-of-the-art SERS for the detection of DNA, proteins and drugs. Moreover, we focus on highlighting the merits and mechanisms of achieving enhanced SERS signals for food safety and clinical treatment. The machine learning techniques, combined with SERS detection, are also indicated herein. This review concludes with recommendations for future studies on the development of SERS.

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Section: Introductionmentioning

confidence: 99%

Novel Surface-Enhanced Raman Spectroscopy Techniques for DNA, Protein and Drug Detection

Chen

Liu

Tian

et al. 2019

Sensors

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“…Surface-Enhanced Raman Scattering (SERS) is becoming a versatile spectroscopic technique in different scientific fields, such as analytical chemistry, for the detection of analytes/contaminants [1,2] at trace levels, even reaching single-molecule detection [3], biochemistry and forensic medicine, [4,5,6] for the detection of RNA by the recognition of adenine and cytosine using silver nanoparticles, pharmaceutical medicine [7], in the study of new target drugs, and other applications in restoration and artistic heritage [8], archeology [8], food [9,10], etc. ; that is, most SERS studies deal with the molecular recognition of vibrational fingerprints of molecules at low concentration.…”

Section: Introductionmentioning

confidence: 99%

A DFT Approach to the Surface-Enhanced Raman Scattering of 4-Cyanopyridine Adsorbed on Silver Nanoparticles

et al. 2019

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A Surface-Enhanced Raman Scattering (SERS) spectrum of 4-cyanopyridine (4CNPy) was recorded on silver plasmonic nanoparticles and analyzed by using Density Functional Theory (DFT) calculations. Two simple molecular models of the metal–4CNPy surface complex with a single silver cation or with a neutral dimer (Ag+–4CNPy, Ag2–4CNPy), linked through the two possible interacting sites of 4CNPy (aromatic nitrogen, N, and nitrile group, CN), were considered. The calculated vibrational wavenumbers and intensities of the adsorbate and the isolated species are compared with the experimental Raman and SERS results. The analysis of the DFT predictions and the experimental data indicates that 4CNPy adsorbs preferentially on neutral/charged active sites of the silver nanoparticles through the nitrogen atom of the aromatic ring with a perpendicular orientation.

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“…A common problem that stands in the widespread, routine quantitative analytical use of both SERS and NELIBS is that robust substrates having a very even and well controlled NP surface distribution, thereby generating a reproducible signal enhancement, and a long lifetime are needed, which are not easy to fabricate. Most applications therefore focus on "qualitative detection" or "sensing" of certain analytes, instead of quantitative analysis [15,16].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Nanoparticle enhanced laser induced breakdown spectroscopy of liquid samples by using modified surface-enhanced Raman scattering substrates

Palásti

Albrycht

Janovszky

et al. 2020

Spectrochimica Acta Part B: Atomic Spectroscopy

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Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field

Cited by 81 publications

References 101 publications

Novel Surface-Enhanced Raman Spectroscopy Techniques for DNA, Protein and Drug Detection

Novel Surface-Enhanced Raman Spectroscopy Techniques for DNA, Protein and Drug Detection

A DFT Approach to the Surface-Enhanced Raman Scattering of 4-Cyanopyridine Adsorbed on Silver Nanoparticles

Nanoparticle enhanced laser induced breakdown spectroscopy of liquid samples by using modified surface-enhanced Raman scattering substrates

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