Critical Review of Pharmacology, Toxicology, Pharmacokinetics of Vincristine, Vindesine, Vinblastine

Brade, W.

doi:10.1159/000428623

Cited by 12 publications

(7 citation statements)

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“…11 Vincristine binds strongly to axonal microtubules. 4 This high affinity for neural tissue may mean that after vincristine is absorbed transderamally it binds strongly to axon terminals, thus allowing minimal, if any, drug leak into the circulation. Lack of alterations in blood cell counts is supportive evidence that vincristine is not absorbed systemically.…”

Section: Discussionmentioning

confidence: 99%

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Iontophoretic Vincristine in the Treatment of Postherpetic Neuralgia

Dowd

Day

Timon

et al. 1999

Journal of Pain and Symptom Management

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The effect of iontophoretic administration of vincristine in the treatment of postherpetic neuralgia (PHN) was investigated in a prospective, double-blind, placebo-controlled trial. Twenty patients with intercostal or lumbar PHN for more than 6 months that was unresponsive to conventional medical therapy were randomized to receive vincristine 0.01% (n = 11) or saline (n = 9), by iontophoresis over 1 hour daily for 20 days. Demographics and median duration of pain were similar in both groups. Pain scores decreased over the treatment period and were significantly lower on day 20 compared to baseline in both groups. Pain relief was described as moderate or greater in 40% of patients with vincristine and 55% of patients with placebo. There was no statistical difference an actual pain scores on day 20 between the two groups. Moderate or greater pain relief was maintained in 30% of patients with vincristine and 33% of patients with placebo at follow-up on day 90. We conclude that iontophoresed vincristine is no better than iontophoresed saline in the treatment of PHN. The maintained improvement in both groups at 3 months follow-up may reflect the natural history of PHN, or might possibly by related to a beneficial effect of iontophoresis.

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Section: Discussionmentioning

confidence: 99%

“…Vincristine, a naturally occurring alkaloid of the periwinkle plant, 4 has been used to treat PHN. Previous studies have reported astonishing relief (complete relief of pain in 75%-100%) from the pain of PHN with vincristine administered by iontophoresis.…”

Section: Introductionmentioning

confidence: 99%

Iontophoretic Vincristine in the Treatment of Postherpetic Neuralgia

Dowd

Day

Timon

et al. 1999

Journal of Pain and Symptom Management

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“…This results in inhibition of tubulin polymerization which interrupts mitosis and leads to cell death. 3 Vindesine is considered to be cell-cycle specific and exerts its maximum lethal effects to cells during the "S" phase of the cell ~y c l e .~,~…”

Section: Chemistrymentioning

confidence: 99%

Pharmacology, Clinical Efficacy and Adverse Effects of Vindesine Sulfate, A New Vinca Alkaloid

et al. 1983

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Vindesine is a new vinca alkaloid antineoplastic agent derived from vinblastine. However, its antineoplastic spectrum more closely resembles that of vincristine. Clinical studies indicate activity against acute leukemia, lung cancer, carcinoma of the breast, squamous cell carcinoma of the esophagus and head and neck, Hodgkin's disease and non-Hodgkin's lymphomas. Pharmacokinetic studies indicate that vindesine exhibits a triphasic elimination pattern with a terminal half-life of 24.2 hours. Elimination is primarily through hepatic metabolism. The major side effects associated with vindesine therapy are myelosuppression and neurotoxicity. Other side effects include alopecia, nausea and vomiting and local tissue irritation associated with extravasation. Vindesine will be a positive addition to the antineoplastic armamentarium. The full extent of its activity remains to be established.

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“…Κατά σειράν συχνότητας εμφανίσεως ή έλάττωσις τών τενοντίων αντανακλάσεων καί ιδιαίτερα τοϋ αχιλλείου τένοντος είναι τό συχνότερο εύρημα. 'Ακολουθείται άπό παραισθησίες, μυϊκή αδυναμία, κινητικές διαταραχές, δυσκοιλιότητα, μυαλ γίες καί παραλυτικό ειλεό 15 . "Οπως καί μετά από χορήγηση Vincristine, δεν παρατηρούνται δοσοεξαρτώμενες αισθητικές διαταραχές 174177178 .…”

Section: δσυζητησηunclassified

“…καί ΗΜΜ 165 ένώ πα ρατηρείται στό 9% 55 -3 5 % ι "τών ασθενών μετά άπό χορήγηση VM-26. Μετά άπό χορήγη ση τοϋ Vindesine ή αλωπεκία είναι συχνή παρενέργεια 15 . Οί παρατηρήσεις μας επομένως έπί τοϋ θέματος συμφωνούν μέ τά βιβλιογραφικά δεδομένα, καθόσον οτι οί παρατηρηθεΤσες περι πτώσεις αλωπεκίας παρατηρήθηκαν μέ τήν χορήγηση τοϋ σχήματος Β.…”

Section: δσυζητησηunclassified

Μελετη Για Την Αντιμετωπιση Των Ανθεκτικων Λεμφωματων Με Δυο Νεα Χημειοθεραπευτικα Σχηματα

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Critical Review of Pharmacology, Toxicology, Pharmacokinetics of Vincristine, Vindesine, Vinblastine

Cited by 12 publications

References 0 publications

Iontophoretic Vincristine in the Treatment of Postherpetic Neuralgia

Iontophoretic Vincristine in the Treatment of Postherpetic Neuralgia

Pharmacology, Clinical Efficacy and Adverse Effects of Vindesine Sulfate, A New Vinca Alkaloid

Μελετη Για Την Αντιμετωπιση Των Ανθεκτικων Λεμφωματων Με Δυο Νεα Χημειοθεραπευτικα Σχηματα

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