Palmer amaranth is the latest pigweed species documented in Connecticut in 2019. In a single dose experiment, the Connecticut Palmer amaranth biotype survived the field–use rates of glyphosate (840 g ae ha-1) and imazaquin (137 g ai ha-1) herbicides applied separately. Additional experiments were conducted to (1) determine the level of resistance to glyphosate and acetolactate synthase (ALS) inhibitors in the Connecticut–resistant (CT–Res) biotype using whole-plant dose-response bioassays, and (2) evaluate the response of the CT–Res biotype to POST herbicides commonly used in CT cropping systems. Based on the effective dose required for 90% control (ED90), the CT–Res biotype was 10–fold resistant to glyphosate when compared with the Kansas– susceptible (KS–Sus) biotype. Furthermore, the CT–Res biotype was highly resistant to ALS–inhibitor herbicides with only 18% control with 2,196 g ai ha-1 of imazaquin. It was also cross resistant to other ALS–inhibitor herbicides including: chlorimuron–ethyl (13.1 g ai ha-1), halosulfuron–methyl (70 g ai ha-1), and sulfometuron–methyl (392 g ai ha-1). The CT–Res Palmer amaranth was controlled 75 to 100% at 21 d after treatment (DAT) with POST applications of 2, 4–D (386 g ae ha-1), carfentrazone–ethyl (34 g ai ha-1), clopyralid (280 g ae ha-1), dicamba (280 g ae ha-1), glufosinate (595 g ai ha-1), lactofen (220 g ai ha-1), oxyfluorfen (1,121g ai ha-1), and mesotrione (105 g ai ha-1) herbicides. Atrazine (2,240 g ai ha-1) controlled the CT–Res biotype only 52%, suggesting the biotype is resistant to this herbicide as well. This research reports the first case of Palmer amaranth from Connecticut with multiple resistance to glyphosate and ALS–inhibitors. Growers should proactively use all available weed control tactics, including the use of effective PRE and alternative POST herbicides (tested in this study) for effective control of the CT–Res biotype.