Critical inflammatory mechanisms underlying arrhythmias

Vonderlin, Nadine; Siebermair, Johannes; Kaya, Elif; Köhler, Miriam; Rassaf, Tienush; Wakili, Reza

doi:10.1007/s00059-019-4788-5

Cited by 34 publications

(32 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the mechanisms for the development of arrhythmias in these patients are not completely understood, it is possible that the arrhythmias occur secondary to a direct effect of the cytokines on the electrical system, similar to what has been found in patients with inflammatory diseases like rheumatoid arthritis [38] or myocarditis, or in patients after cardiac surgery [39] (Figure 2).…”

Section: Arrhytmyas Related To Car T-cell Therapymentioning

confidence: 56%

“…Similarly, inflammation has been associated with the initiation and maintenance of atrial fibrillation. [49] The proposed mechanisms for the development of atrial fibrillation include abnormal calcium homeostasis caused by ILs and tumor necrosis factor a [39] as well as downregulation of connexins 43 and 40 by IL-6. [50] There are multiple studies demonstrating the association with elevated inflammatory biomarkers, especially CRP with persistent atrial fibrillation.…”

Section: Arrhytmyas Related To Car T-cell Therapymentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias

Simbaqueba

Aponte

Kim

et al. 2020

Journal of Immunotherapy and Precision Oncology

View full text Add to dashboard Cite

In recent years, cancer treatment has evolved, and new therapies have been introduced with significant improvement in prognosis. The immunotherapies stand out owing to their efficacy and remission rate. Chimeric antigen receptor (CAR) T-cell therapy is a part of this new era of therapies. Chimeric antigen receptor T-cell therapy is a form of adoptive cellular therapy that uses a genetically encoded CAR in modified human T cells to target specific tumor antigens in a nonconventional, non-major histocompatibility complex (MHC) protein presentation. Chimeric antigen receptor T-cell therapy successfully identifies tumor antigens and through activation of T cells destroys tumoral cells. It has been found to efficiently induce remission in patients who have been previously treated for B-cell malignancies and have persistent disease. As the use of this novel therapy increases, its potential side effects also have become more evident, including major complications like cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Cytokine release syndrome is a major systemic inflammatory process as a result of massive cytokine production by the proliferating and activated CAR T cells in which multiple interleukins and immune cells contribute to the inflammatory response. Cytokine release syndrome has been associated with cardiovascular life-threatening complications including hypotension, shock, tachycardia, arrhythmias, left ventricular dysfunction, heart failure, and cardiovascular death. Arrhythmias, among its major complications, vary from asymptomatic prolonged corrected QT interval (QTc) to supraventricular tachycardia, atrial fibrillation, flutter, and ventricular arrhythmias like Torsade de pointes. This article focuses on the cardiovascular complications and arrhythmias associated with CRS and CAR T-cell therapy.

show abstract

Section: Arrhytmyas Related To Car T-cell Therapymentioning

confidence: 56%

Section: Arrhytmyas Related To Car T-cell Therapymentioning

confidence: 99%

Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias

Simbaqueba

Aponte

Kim

et al. 2020

Journal of Immunotherapy and Precision Oncology

View full text Add to dashboard Cite

show abstract

“…65,66 It may be related to ion channel mutations, such as SCN5A in Brugada syndrome. 64 Besides, abnormal sodium current also plays an important role. 67,68 In addition, fever can cause tachyarrhythmias in individuals without inherited heart disease.…”

Section: Putative Mechanis Ms Of Arrhy Thmia S In Sar S -Cov-2mentioning

confidence: 99%

“…All these will promote the development of reentrant arrhythmias such as malignant ventricular arrhythmia. 64,77 In addition, acute left atrial ischemia led to ATP-sensitive potassium current (IKATP) conductor-dependent shortened APD, as well as spontaneous focal discharges and reentry loops. 79 Chronic atrial ischemia/ infarction promoted atrial fibrillation by unprompted ectopy and sustained reentry.…”

Section: Putative Mechanis Ms Of Arrhy Thmia S In Sar S -Cov-2mentioning

confidence: 99%

Cardiac arrhythmias in patients with COVID‐19

Wang

Tse

et al. 2020

Journal of Arrhythmia

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has reached pandemic status. Although clinical manifestations in patients with COVID-19 are mainly related to the respiratory system, cardiovascular complications have also been identified in the earliest reported cases from Wuhan, the epicenter of the outbreak. 1-3 COVID-19 can significantly affect cardiac function and induce cardiac injury. And the latter is associated with increased disease

show abstract

“…Inflammation is also related to tissue repair after injury. Tissue repair is accompanied by parenchymal cell regeneration and finally fibrous tissue formation, namely, scar formation ( Klein et al, 2000 ; Said et al, 2011 ; Gorenek et al, 2014 ; Vonderlin et al, 2019 ).…”

Section: Macrophage-related Inflammation and Ventricular Arrhythmiasmentioning

confidence: 99%

The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias

Chen

Wang

et al. 2020

Front. Physiol.

View full text Add to dashboard Cite

In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.

show abstract

Critical inflammatory mechanisms underlying arrhythmias

Cited by 34 publications

References 73 publications

Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias

Cardiovascular Complications of Chimeric Antigen Receptor T-Cell Therapy: The Cytokine Release Syndrome and Associated Arrhythmias

Cardiac arrhythmias in patients with COVID‐19

The Role of Cardiac Macrophage and Cytokines on Ventricular Arrhythmias

Contact Info

Product

Resources

About