Critical In Vitro Factors in Evaluation of Gastric Antacids I

Critical In Vitro Factors in Evaluation of Gastric Antacids II

“…Tpepsin on the in vitro activity of noneffervescent antacids has recently been reported (1). The significance of these findings is that similar inhibition might occur in the stomach.…”

“…This reasoning is supported by the results depicted in Figs. 1 and 2. A definite relationship exists between these two evaluatory procedures.…”

“…After intervals of 15, 30, 45, and 60 minutes, the contents of successive tlasks were rapidly filtered in vacuo, and the filtrate was analyzed for nitrogen content by a micro-Kjeldahl technique. 1 The results, summarized in Table I, show that the glutamic acid content in the solution had remained constant during the course of the reaction.…”

“…Relationship of Rate of Neutralization to Bullering Capacity.-It has been proposed that the polypeptide inhibitory effect on the ouffering capacity of noneffervescent antacids indicates a kinetic or reversible phenomenon rather than an irreversible state (1). This conclusion was based on t h e observation that the polypeptides had no effect on the total volume of acid neutralized but reduced the maximum pH attained auring the course of the experiments.…”