Most investigations on forced convective boiling have been conducted by using uniformly heated round tubes under a vertical upward flow condition, although the actual system has a non‐uniformly heated condition with several tube orientations. The non‐uniformity of the heat flux and tube inclination causes the liquid film distribution, which in turn affects the critical heat flux. In this investigation, the flow and heat‐transfer characteristics were experimentally investigated under non‐uniformly heated conditions along the circumferential direction with a 45° tube inclination. In the experiment, CHF was measured by using two different heated lengths, i.e., 900 and 1800 mm. The experimental results showed a unique tendency of CHF caused by the interrelationship of the non‐uniform heat flux distribution, the tube inclination, and liquid film redistribution. © 2011 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/htj.20333