Critical discussion on a method for derivation of reference limits in clinical chemistry from a patient population

Hemel, Jan; Hindriks, Fr; Vanderslik, W

doi:10.1155/s1463924685000062

Cited by 14 publications

(11 citation statements)

References 1 publication

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“…Where the Bhattacharya plot was found to be bent, a Gamma curve was selected as a model for the parameters distribution. This was in accordance with the selection criteria as recommended by Hemel et al 1985.…”

Section: S T a T I S T I C A L M E T H O D Smentioning

confidence: 53%

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Reference ranges for haematology parameters in pregnancy derived from patient populations

Balloch

Cauchi

2008

Clinical &Amp; Laboratory Haematology

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Summary Reference ranges for several haematology parameters in pregnancy were determined by the mathematical detection of Gaussian and Gamma distributions in partitioned but unselected patient data. For each trimester, red cell parameters were shown to be well described by Gaussian distributions. Platelet and white cell parameters were best described by Gamma distributions with the exception of eosinophil and basophil counts for which neither distribution was applicable. The reference ranges derived for each trimester are compared.

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Section: S T a T I S T I C A L M E T H O D Smentioning

confidence: 53%

“…The estimation of the R value (degrees of freedom) and 3, value (extension factor) of the Gamma curves were performed as described by Hemel et al 1985.…”

Section: S T a T I S T I C A L M E T H O D Smentioning

confidence: 99%

Reference ranges for haematology parameters in pregnancy derived from patient populations

Balloch

Cauchi

2008

Clinical &Amp; Laboratory Haematology

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“…Bhattacharya analysis derives a reference interval by the identification of a Gaussian distribution from a particular data set. However, for the analysis to be valid, the data set must show a distribution that is close to Gaussian, with only distortion from pathological cases in the tails . Therefore, we evaluated whether the log‐transformed PTH data from subjects with a 25‐OHD concentration of 75 nmol/L or greater met this criterion.…”

Section: Resultsmentioning

confidence: 99%

“…Bhattacharya analyses were performed using software available online . The software employs Naus’ modification of the Bhattacharya method . Bhattacharya analysis was performed after log transformation of data, and the goodness of fit of each analysis was assessed using a residual plot.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, stratification of subjects into multiple age‐ and sex partitions is possible without the loss of statistical power, even after applying rigorous exclusion criteria. Furthermore, statistical tools, such as Bhattacharya analysis, are available that can derive reference intervals from these data sets without the need to identify and exclude all subjects with parathyroid dysfunction . Data mining analysis has been shown to give reference intervals that closely match those of direct reference interval studies for a variety of analytes …”

Section: Introductionmentioning

confidence: 99%

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Parathyroid hormone: Data mining for age‐related reference intervals in adults

Farrell¹,

Nguyễn²,

Carter³

2017

Clinical Endocrinology

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Cholesterol levels in normal Irish adults: The mater hospital cholesterol screening survey

Collier¹,

Maguire²,

McGing³

et al. 1996

I.J.M.S.

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Serum samples from 954 Irish adults (604 males, 350 females) aged 18 to 65 years were analyzed within 24 hours of receipt for non-fasting total serum cholesterol levels. The subjects were volunteer blood donors (Blood Transfusion Service Board, Pelican House, Dublin) presenting from June 1990 to February 1991. Serum cholesterol increased significantly with age in both males and females. Mean serum cholesterol in males increased from 4.5 (+/- 0.9) mmol/l in those < 25 years, to 5.7 (+/- 1.0) mmol/l at age 55-64 years. In females, mean serum cholesterol increased from 4.3 (+/- 0.9) mmol/l less than 25 years to 6.2 (+/- 0.8) mmol/l at age 55-64 years. Options for reporting cholesterol ranges are discussed. The overall mean cholesterol concentration of 5.1 mmol/l seen in this study is lower than that reported for comparable studies of U.K. and American subjects, but higher than observed in Japanese individuals. Almost 48% of the studied population had a serum cholesterol value less than 5 mmol/l and over 56% had levels less than 5.2 mmol/l.

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Critical discussion on a method for derivation of reference limits in clinical chemistry from a patient population

Cited by 14 publications

References 1 publication

Reference ranges for haematology parameters in pregnancy derived from patient populations

Reference ranges for haematology parameters in pregnancy derived from patient populations

Parathyroid hormone: Data mining for age‐related reference intervals in adults

Cholesterol levels in normal Irish adults: The mater hospital cholesterol screening survey

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