Critical Components of the Pluripotency Network Are Targets for the p300/CBP Interacting Protein (p/CIP) in Embryonic Stem Cells

Chitilian, Jennifer M.; Thillainadesan, Gobi; Manias, Janet L.; Chang, Wing Y.; Walker, Emily M.; Isovic, Majdina; Stanford, William L.; Torchia, Joseph

doi:10.1002/stem.1564

Cited by 18 publications

(16 citation statements)

References 55 publications

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“…Yki acts in enteroblasts to support regenerative division of intestinal stem cells (reviewed in Lucchetta and Ohlstein, 2012) while Tai supports stem cell development in the female germline (Konig et al, 2011). Intriguingly the hormone estrogen and the Tai-ortholog NCOA3, which interacts with the estrogen receptor, each support stem cell pools in vertebrates (Chitilian et al, 2014; Nakada et al, 2014), indicative of a potential conserved link between hormone signaling and stem cell renewal. Tai and Yki also each act cell-autonomously to support invasive behavior of somatic border cell clusters in the ovary (Bai et al., 2000; Lucas et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue

Zhang

Robinson

et al. 2015

Developmental Cell

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The Hippo pathway is a conserved signaling cascade that modulates tissue growth. Although its core elements are well defined, factors modulating Hippo transcriptional outputs remain elusive. Here we show that elements of the steroid-responsive ecdysone (Ec) pathway modulate Hippo transcriptional effects in imaginal disc cells. The Ec receptor coactivator Taiman (Tai) interacts with the Hippo transcriptional coactivator Yorkie (Yki) and promotes expression of canonical Yki-responsive genes. Tai enhances Yki-driven growth while Tai loss, or a form of Tai unable to bind Yki, suppresses Yki-driven tissue growth. This growth suppression is not correlated with impaired induction of canonical Hippo-responsive genes but with suppression of a distinct pro-growth program of Yki-induced/Tai-dependent genes, including the germline stem cell factors nanos and piwi. These data reveal Hippo/Ec pathway crosstalk in the form a Yki-Tai complex that collaboratively induces germline genes as part of a transcriptional program that is normally repressed in developing somatic epithelia.

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Section: Discussionmentioning

confidence: 99%

The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue

Zhang

Robinson

et al. 2015

Developmental Cell

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“…Likewise, in human embryonic stem cells, TGF-β was recently found to recruit SMAD2/3 to TEAD/YAP/TAZ complexes in association with OCT4, contributing to the regulation of pluripotency genes (Beyer et al, 2013). The latter have been shown independently to be targets for the p300/CBP-interacting protein (p/CIP), which is required for transcriptional activity of various CBP/p300-dependent transcription factors (Chitilian et al, 2014). These data are consistent with the demonstration that external signaling and the core transcriptional machinery form tightly integrated regulatory networks in embryonic stem cells (Chen et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

et al. 2015

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SUMMARY Cell-cell contacts inhibit cell growth and proliferation in part by activating the Hippo pathway that drives the phosphorylation and nuclear exclusion of the transcriptional coactivators YAP and TAZ. Cell density and Hippo signaling have also been reported to block transforming growth factor β (TGF-β) responses, based on the ability of phospho-YAP/TAZ to sequester TGF-β-activated SMAD complexes in the cytoplasm. Herein, we provide evidence that epithelial cell polarization interferes with TGF-β signaling well upstream and independent of cytoplasmic YAP/TAZ. Rather, polarized basolateral presentation of TGF-β receptors I and II deprives apically delivered TGF-β of access to its receptors. Basolateral ligand delivery nonetheless remains entirely effective to induce TGF-β responses. These data demonstrate that cell-type-specific inhibition of TGF-β signaling by cell density is restricted to polarized epithelial cells and reflects the polarized distribution of TGF-β receptors, which thus affects SMAD activation irrespective of Hippo pathway activation.

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“…In embryonic stem cells, TBX3 is a direct transcriptional target of SRC3 which provides a potential integration of steroid signalling and the determination of HS-MEC lineage specification [165].…”

Section: Tbx3mentioning

confidence: 99%

Hormone-Sensing Mammary Epithelial Progenitors: Emerging Identity and Hormonal Regulation

Tarulli

Laven-Law

Shakya

et al. 2015

J Mammary Gland Biol Neoplasia

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The hormone-sensing mammary epithelial cell (HS-MEC-expressing oestrogen receptor-alpha (ERα) and progesterone receptor (PGR)) is often represented as being terminally differentiated and lacking significant progenitor activity after puberty. Therefore while able to profoundly influence the proliferation and function of other MEC populations, HS-MECs are purported not to respond to sex hormone signals by engaging in significant cell proliferation during adulthood. This is a convenient and practical simplification that overshadows the sublime, and potentially critical, phenotypic plasticity found within the adult HS-MEC population. This concept is exemplified by the large proportion (~80 %) of human breast cancers expressing PGR and/or ERα, demonstrating that HS-MECs clearly proliferate in the context of breast cancer. Understanding how HS-MEC proliferation and differentiation is driven could be key to unraveling the mechanisms behind uncontrolled HS-MEC proliferation associated with ERα- and/or PGR-positive breast cancers. Herein we review evidence for the existence of a HS-MEC progenitor and the emerging plasticity of the HS-MEC population in general. This is followed by an analysis of hormones other than oestrogen and progesterone that are able to influence HS-MEC proliferation and differentiation: androgens, prolactin and transforming growth factor-beta1.

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Critical Components of the Pluripotency Network Are Targets for the p300/CBP Interacting Protein (p/CIP) in Embryonic Stem Cells

Cited by 18 publications

References 55 publications

The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue

The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

Hormone-Sensing Mammary Epithelial Progenitors: Emerging Identity and Hormonal Regulation

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