Critical care of patients with cancer

Shimabukuro‐Vornhagen, Alexander; Böll, Boris; Kochanek, Matthias; Azoulay, E.; Bergwelt‐Baildon, Michael S. von

doi:10.3322/caac.21351

Cited by 111 publications

(68 citation statements)

References 284 publications

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“…The findings are consistent with what Halliday, Baker [34] found, namely that HEN was common in patients diagnosed with upper gastrointestinal (GI) cancer who could not meet nutrition requirements with oral intake. The increased prevalence of cancer survivors furthermore is attributed to the development of more effective modern oncology therapies and advances in critical care [35]. Again, patients and/or family caregivers told us that they were informed or involved in decision making regarding the method of nutritional therapy.…”

Section: Discussionmentioning

confidence: 99%

Perceived needs of patients and family caregivers regarding home-based enteral nutritional therapy in South Africa: A qualitative study

Mooi

Ncama

2020

PLoS ONE

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Introduction The need for specialized care, particularly enteral nutritional therapy in community settings is now increasing with implications for both patients and primary care providers. More research is needed to identify the needs of patients and primary caregivers. The study aimed to explore the perceived support needs regarding the provision of home-based enteral nutritional therapy among critically ill adult patients and family caregivers in the Kwa-Zulu-Natal Province of South Africa. Methods A qualitative study of purposely selected adult patients on homebased enteral nutritional therapy and family caregivers was conducted in a district hospital, a community health centre, two primary health care clinics and selected households in the KwaZulu-Natal Province, South Africa. Semi-structured individual interviews were conducted between June and September 2018 and the content analysis approach was used to analyse data. Results Two major themes and five subthemes emerged from the results of the interviews. The major themes concerned socioeconomic and psychosocial support needs related to the provision of home-based enteral nutritional therapy. Subthemes included the need for financial assistance, need for enteral nutrition products and supplementary supplies, need for infrastructure for continuity of care, and psychological support needs. Conclusion Results of this study confirm the need for developing strategies adapted to a South African context and yonder to meet patients' and family caregivers' needs with regard to nutritional services. More research on the identification of needs through monitoring and evaluation of

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Section: Discussionmentioning

confidence: 99%

Perceived needs of patients and family caregivers regarding home-based enteral nutritional therapy in South Africa: A qualitative study

Mooi

Ncama

2020

PLoS ONE

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“…With recent progress in intensive chemotherapeutic regimens and hematopoietic stem cell transplantation, the cancer-related mortality rate has declined gradually. Thus, ICUs are required to provide life-sustaining treatments for infection or chemotherapy-related toxicity events to patients with cancer [35]. Corapi et al [20] found that the absence of Gal-1 in the T lymphocytes of patients with prostate cancer potentiated anti-tumor immune responses.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients

Chou

Tsai

et al. 2020

Preprint

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Background: Galectin-1 (Gal-1), a member of the β-galactoside binding protein family, is associated with inflammation and chronic kidney disease. However, the effect of Gal-1 on mortality and acute kidney injury (AKI) in critically ill patients remains unclear.Methods: From May 2018 to March 2020, 350 patients admitted to the medical intensive care unit (ICU) of Taipei Veterans General Hospital, a tertiary medical center, were enrolled in this study. Forty-one patients receiving long-term renal replacement therapy were excluded. Serum Gal-1 levels were determined within 24 h of ICU admission. The patients were divided into three equally sized groups according to their serum Gal-1 levels (low, serum Gal-1 < 39 ng/ml; median, 39–70 ng/ml; high, >71 ng/ml). All patients were followed for 90 days or until death.Results: Mortality in the ICU and at 90 days was greater among patients with elevated serum Gal-1 levels. In analyses adjusted for the body mass index, malignancy, sepsis, Sequential Organ Failure Assessment (SOFA) score, and serum lactate level, the serum Gal-1 level remained an independent predictor of 90-day mortality [median vs. low: adjusted hazard ratio (aHR) 2.11, 95% confidence interval (CI) 1.24–3.60, p = 0.006; high vs. low: aHR 3.21, 95% CI 1.90–5.42, p < 0.001]. Higher serum Gal-1 levels were also associated with a higher incidence of AKI within 48 h after ICU admission, independent of the SOFA score and renal function (median vs. low: aHR 2.77, 95% CI 1.21–6.34, p = 0.016; high vs. low: aHR 2.88, 95% CI 1.20–6.88, p = 0.017). The results were consistent among different subgroups with high and low Gal-1 levels.Conclusion: Serum Gal-1 elevation at the time of ICU admission were associated with an increased risk of mortality at 90 days, and an increased incidence of AKI within 48 h after ICU admission.

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“…Actuellement, une prolongation de la survie des patients atteints d'un cancer est observée grâce à une amélioration des bilans oncologiques, à une détection plus précoce de la maladie, à l'utilisation de chimiothérapies intensives et de nouveaux traitements biologiques (immunothérapie et thérapies ciblées) qui aboutissent dans certains cas à une augmentation du taux de guérison 4,5 .…”

Section: Introductionunclassified

Elderly patients with cancer in the ICU

Sirjacques¹,

Ameye²,

Berghmans³

et al. 2018

Rev Med Brux

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RESUME Introduction : Il existe très peu de données sur la survie des patients âgés atteints d'un cancer admis en réanimation. Le but de cette étude est d'évaluer chez ces patients de ≥ ≥ ≥ ≥ ≥ 65 ans les facteurs pronostiques de mortalité hospitalière et de survie après sortie de l'hôpital. Méthodes : Etude rétrospective incluant tous les patients ≥ ≥ ≥ ≥ ≥ 65 ans atteints d'une tumeur solide ou hématologique admis pour une complication aiguë à l'Unité de Soins intensifs (USI) du 1/1/2012 au 31/12/2014. Résultats : 311 admissions (de 270 patients différents) ont été enregistrées. Les principaux motifs d'admission sont d'origine cardiovasculaire (22 %), respiratoire (17 %) et hémodynamique (13 %). Les taux de mortalité à l'USI et durant l'hospitalisation sont respectivement de 10 % et 22 %. Les facteurs pronostiques indépendants de mortalité hospitalière sont l'usage de ventilation non invasive (VNI) ou de ventilation mécanique invasive (VMI) et l'existence d'une limitation thérapeutique dans les premières 24 h. Pour la survie après la sortie de l'hospitalisation, les facteurs pronostiques indépendants sont lescore de Charlson ≥ ≥ ≥ ≥ ≥ 8, le score IGS II ≥ ≥ ≥ ≥ ≥ 37, l'administration d'amines dans les premières 24 h et l'existence d'une limitation thérapeutique dans les premières 24 h. 77 % des patients ont pu bénéficier d'un traitement oncologique après leur sortie de l'hôpital. Conclusion : L'existence d'une limitation thérapeutique est associée avec la mortalité hospitalière et la survie après la sortie de l'hôpital. Cependant, la plupart des patients peuvent encore bénéficier d'un traitement oncologique après leur sortie. Rev Med Brux 2018 ; 39 : 487-94 ABSTRACT Introduction : There is very little data on the survival of elderly patients with cancer admitted to intensive care unit (ICU). The aim of the study is to evaluate in our department prognostic factors for hospital mortality and survival after hospital discharge for patients aged ≥ ≥ ≥ ≥ ≥ 65 years. Patients and Methods : Retrospective study including all patients ≥ ≥ ≥ ≥ ≥ 65 with a solid or hematological tumor admitted for an acute complication in an oncological ICU from 01/01/2012 to 31/12/2014. Results : We recorded 311 admissions for 270 patients. The main reasons for admission were cardiovascular (22 %), respiratory (17 %) and hemodynamic (13 %). ICU and in-hospital mortality rates were respectively 10 % and 22 %.The identified independent prognostic factors for higher hospital mortality were the use of non invasive ventilation (NIV) use or of invasive mechanical ventilation (IMV) use and the existence of a therapeutic limitation in the first 24 hours. After hospital discharge, independent prognostic factors for death were Charlson's score ≥ ≥ ≥ ≥ ≥ 8, SAPS II score e» 37, administration of amines in the first 24 hours and the existence of a lifesustaining therapeutic limitation in the first 24 hours. A total of 77 % of patients were able to benefit from an antineoplastic treatment after hospital discharge. Conclusion : Life-sustaining therapeu...

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Critical care of patients with cancer

Cited by 111 publications

References 284 publications

Perceived needs of patients and family caregivers regarding home-based enteral nutritional therapy in South Africa: A qualitative study

Perceived needs of patients and family caregivers regarding home-based enteral nutritional therapy in South Africa: A qualitative study

Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients

Elderly patients with cancer in the ICU

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