Critical care issues in the patient with chronic renal failure

Dember, Laura M.

doi:10.1016/s0749-0704(01)00005-7

Cited by 11 publications

(2 citation statements)

References 78 publications

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“…[4][5][6] Patients with ESRD constitute a significant fraction of patients requiring ICU admission. [7] This is only expected to increase with the improvement in life expectancy offered by various modalities of renal replacement therapy (RRT). Only a few studies have looked into the outcome of ESRD patients admitted in ICUs.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Patients with End Stage Renal Disease Admitted to an Intensive Care Unit in India

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Outcome of Patients with End Stage Renal Disease Admitted to an Intensive Care Unit in India

et al. 2010

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“…Dialysis is primarily employed for treating CRF but it accompanies bleeding and hemorrhages at the site of vascular access potentially leading to cardiovascular diseases (Dember, 2002). Pharmacological interventions have not been successful in the clinical setting (Chatterjee and Thiemermann, 2003).…”

Section: Introductionmentioning

confidence: 99%

Wen‐pi‐tang‐Hab‐Wu‐ling‐san, an oriental herbal prescription, attenuates epithelial‐mesenchymal transdifferentiation stimulated by TGF‐β1 in kidney cells

Lee

Kim

Baek

et al. 2007

Phytotherapy Research

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Wen-pi-tang-Hab-Wu-ling-san (WHW), an oriental herbal prescription, is currently used in oriental clinics for the treatment of chronic renal failure (CRF). While its effectiveness has been supported by a series of modern studies, the underlying mechanism remains poorly understood. CRF progression involves tubulointerstitial fibrosis where transforming growth factor-beta1 (TGF-beta1) plays a critical role by inducing epithelial-mesenchymal transdifferentiation (EMT). This study examined whether WHW extract attenuated the TGF-beta1-induced EMT in Madin-Darby canine kidney cells. When the cells were stimulated by TGF-beta1 (2.5 ng/mL), they exhibited an elongated, spindle-shaped appearance but this morphological change was significantly suppressed by WHW extract (1 mg/mL). The WHW extract did not show notable cytotoxicity and even mitigated the cytotoxic effects of TGF-beta1. It inhibited the expression of alpha-smooth muscle actin (alpha-SMA), a marker of EMT, but not the secretion of matrix metalloproteinases stimulated by TGF-beta1. The WHW extract also inhibited the phosphorylation of Smad2 that mediates TGF-beta1 signaling leading to alpha-SMA expression. The present study suggests that WHW extract may provide renal protective effects through modulation of the TGF-beta1/Smad2/alpha-SMA pathway involved in fibrosis.

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