Critical Care Delivery in India: Stats, State(s) and Strategies

Ramakrishnan, Nagarajan; Ramakrishnan, Adarsh

doi:10.5005/jp-journals-10071-24445

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Phytochemical studies of Roccella sp . lichens indicated a wide range of metabolites, including dibenzofurans, [3–5] chromones, [6,7] N ‐containing compounds, [8,9] carbohydrates, [10] and terpenoids [11,12] . Nonetheless, chemical data of Roccella montagnei are scarce, with a few reported phytochemical studies [13–17] .…”

Section: Introductionmentioning

confidence: 99%

Bio‐Guided Isolation of Alpha‐Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei

Thuy Le,

Vu,

Duong

et al. 2024

Chemistry & Biodiversity

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A bio‐guided isolation was applied to the Vietnamese lichen Roccella montagnei based on alpha‐glucosidase inhibition. Six compounds were isolated and structurally elucidated, including a new ortho depside, montagneside A (1), together with five known compounds, sekikaic acid (2), lanost‐7‐en‐3β‐ol (3), ethyl orsellinate (4), D‐montagnetol (5), and D‐erythrin (6). Their chemical structures were identified by extensive 1D and 2D NMR analysis, high‐resolution mass spectroscopy, and comparisons with those reported in the literature. D‐Erythrin (6), a major component, was selected for further modification using Smiles rearrangement. Three erythritol derivatives 6a‐6c were synthesized. Compounds 1‐3, 6, and 6a‐6c were evaluated for alpha‐glucosidase inhibition. Compounds 2 and 6a‐6c showed significant alpha‐glucosidase inhibition with IC50 values ranging from 7.9 to 149 µM, respectively. Molecular docking was applied to the most active compound 6a to clarify the inhibitory mechanism.

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Section: Introductionmentioning

confidence: 99%

Bio‐Guided Isolation of Alpha‐Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei

Thuy Le,

Vu,

Duong

et al. 2024

Chemistry & Biodiversity

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“…In an earlier editorial, we had proposed Tele-ICU as one of the models to improve critical care services in India. 9 However, there have been several barriers to Telehealth in India including technology, cost, and user end expectations. 10 Since digital imaging and picture archiving systems are increasingly available, this may be easier and more accepted with Teleradiology, but the time advantage would be lost and it would be challenging to have radiologists available all night working on a quick turnaround time.…”

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Teleradiology: Geography is now History!

Ramakrishnan

2023

Indian Journal of Critical Care Medicine

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An indigenously developed tele-ICU model to treat severe cases of envenomation in remote regions in India

MB,

Parmar,

Singh

et al. 2024

BMJ Case Rep

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In cases of severe envenomation due to snakebites, patients require antivenom, intensive care management, including respiratory support, haemodynamic monitoring and renal replacement therapy. Early recognition and treatment of complications such as acute kidney injury, rhabdomyolysis and coagulopathy are important to improve outcomes.Tele-ICU models can play a critical role in providing access to critical care expertise and nuanced support to remote healthcare facilities that may not have the necessary resources or expertise to manage complex cases of envenomation. With the help of telemedicine technology, remote intensivists can provide timely guidance on diagnosis and ongoing management, improving the quality of care and outcomes for patients. We discuss two patients in resource-constrained regions of India with severe envenomation who were managed with tele-ICU support.

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Critical Care Delivery in India: Stats, State(s) and Strategies

Abstract: How to cite this article: Ramakrishnan A, Ramakrishnan N. Critical Care Delivery in India: Stats, State(s) and Strategies. Indian J Crit Care Med 2023;27(4):231–232.

Cited by 3 publications

References 11 publications

Bio‐Guided Isolation of Alpha‐Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei

Bio‐Guided Isolation of Alpha‐Glucosidase Inhibitory Compounds from Vietnamese Lichen Roccella Montagnei

Teleradiology: Geography is now History!

An indigenously developed tele-ICU model to treat severe cases of envenomation in remote regions in India

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