Critical Behavior and Psychopathologic Variables of the Parent-Child Couple in Living Kidney Transplantation

Pistorio, Maria Luisa; Pasquale, Concetta De; Veroux, Massimiliano; Martinelli, Valentina; Giaquinta, Alessia

doi:10.1016/j.transproceed.2020.03.003

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Living donation is associated with many complex emotions experienced by donors and recipients, that can be positive (increased emotional engagement and attachment) or negative (strained relationships arising from misaligned expectations, jealousy, and disappointment when adverse outcomes occur) 15 . The emotions experienced can be quite different based on the type of living donor, 16 and this can have a significant potential impact on outcomes by affecting adherence to medical care. One could speculate, that potentially, LURD Tx recipients could be at a higher risk of non‐adherence, since a pre‐existing emotional attachment between the donor and recipient, at least in pediatric recipients, is less likely, making recipients feel less ‘obliged’ to take optimal care of themselves to preserve the well‐being of the Tx.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of living unrelated donor kidney transplants in children: An Organ Procurement and Transplant Network database analysis

Butani

Tancredi

2022

Pediatric Transplantation

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Background There are conflicting data on long‐term outcomes of pediatric LURD renal Txs compared to Txs of kidneys from other donor sources. Methods An analysis of the OPTN database was conducted in children (<18 years) who had received their 1st kidney‐only Tx between January 1, 2000, and September 30, 2021. The primary outcome measure was time to graft failure or death. Cox event history regression model for time to primary outcome, categorized by donor source and adjusting for confounders was performed. Results Of the 12 089 subjects, 327 (2.7%) received kidneys from LURDs, 4349 (36%) from LRDs and 7413 (61%) from DD. One year graft failure rate was 3.56%. On regression analyses, compared to LRD kidney recipients, LURD recipients had comparable graft survival (graft failure AHR 1.15, 95th percentile confidence interval 0.87–1.51; p .31) and DD recipients had lower graft survival (graft failure hazard ratio 1.26, 95th percentile confidence interval 1.10–1.43; p < .001). When using living unrelated kidney recipients as the reference group, DD kidney recipients had comparable graft survival, with a wide confidence interval (hazard ratio for graft failure 1.09; 0.83–1.43, p .53). Conclusions Pediatric LURD kidney recipients have comparable graft survival to LRD kidney recipients; DD kidney recipients had the poorest survival. Our study, the largest to date, should encourage centers to embrace non‐commercial living‐unrelated transplantation as a viable option for children, preferable to DD kidneys.

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Section: Discussionmentioning

confidence: 99%

Outcomes of living unrelated donor kidney transplants in children: An Organ Procurement and Transplant Network database analysis

Butani

Tancredi

2022

Pediatric Transplantation

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“…Pistorio reports a prospective study of kidney donor recipient couples followed up to 24 months posttransplantation. It was noted when the donors were parents, the recipients’ problematic behavior is likely to be associated with worse mental status in the donor [67]. A cross-sectional study of living liver donors found that high levels of depression negatively impacted their physical status and self-efficacy [68].…”

Section: Depression In Transplant-related Special Clinical Groupsmentioning

confidence: 99%

Depression in transplantation

Zimbrean¹

2022

Current Opinion in Organ Transplantation

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Purpose of reviewTo review and summarize the literature published between 1 January 2020 and 30 June 2022, on the prevalence, risk factors and impact of depression in transplant population. Recent findingsDepression is common in transplantation candidates and recipients, with a prevalence up to 85.8% in kidney recipients. Multiple studies have indicated after transplantation depression correlates with increased mortality and with higher healthcare utilization. Social risk factors for posttransplant depression include financial difficulties and unemployment, while less is understood about the biological substrate of depression in this population. There is evidence that dynamic psychotherapy is effective for depression in organ transplant recipients, while cognitive behavioral therapy or supportive therapy did not lead to improvement of depression in transplant recipients. For living organ donors, the rates of depression are similar to the general population, with financial factors and the clinical status of the recipient playing a significant role. SummaryDepression is a common finding in transplant population. More research is needed to understand the biological substrate and risk factors and to develop effective treatment interventions.

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“…Kidney transplantation is a replacement procedure for chronic kidney disease that is intended to improve the patient’s quality of life. However, the experience may be a strongly emotional one, accompanied by difficulty in accepting the new organ, lifestyle changes, the side-effects associated with the procedure, anxiety, depression, the redefinition of one’s body, and a change in social and family roles [ 1 , 2 , 3 , 4 , 5 ]. Hence, the associated stress may result in an adverse post-operative course, particularly in terms of compliance to the follow-up process, medical prescriptions, and the consequential risk of rejection [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Expressive Writing in Kidney Transplanted Patients: A Randomized Controlled Trial Study

et al. 2022

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The present study aimed to assess the effectiveness of an expressive writing (EW) intervention on psychological and physiological variables after kidney transplant. The final sample of 26 were randomly assigned to an expressive writing group (EWG) and control group (CG). Outcomes were focused on depression, anxiety, alexithymia, empathy, resilience, locus of control, creatinine, CDK-EPI, and azotemia. Depressive symptoms and alexithymia levels decreased in the EWG, with better adherence. Resilience declined over time in both groups. The EWG showed a significantly higher CDK-EPI, indicating better renal functioning. EW seems an effective intervention to improve the psychological health of transplanted patients, with a possible effect on renal functioning. These findings open the possibility of planning brief psychological interventions aimed at processing emotional involvement, in order to increase adherence, the acceptance of the organ, and savings in healthcare costs.

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Critical Behavior and Psychopathologic Variables of the Parent-Child Couple in Living Kidney Transplantation

Cited by 5 publications

References 15 publications

Outcomes of living unrelated donor kidney transplants in children: An Organ Procurement and Transplant Network database analysis

Outcomes of living unrelated donor kidney transplants in children: An Organ Procurement and Transplant Network database analysis

Depression in transplantation

Effectiveness of Expressive Writing in Kidney Transplanted Patients: A Randomized Controlled Trial Study

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