Critical areas of cell adhesion on micropatterned surfaces

Yan, Changhao; Sun, Jianguo; Ding, Jiandong

doi:10.1016/j.biomaterials.2011.01.078

Cited by 100 publications

(83 citation statements)

References 74 publications

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“…Davidson et al showed that interaction of the normal cells with the topographically patterned surfaces was different from that of the cancer cells and plasma membranes of the normal cells were not easily deformed when the contact area between surface and cells was increased [4]. Yan et al suggested that cell binding locations and properties can be controlled by designing specific micropattern sizes [29]. These findings show that micropatterned surfaces may be used in selective adsorption of different cell types.…”

Section: Introductionmentioning

confidence: 99%

Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

Gengec¹,

Gulsuner²,

Erbil³

et al. 2014

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThe objective of this study is to prepare polymeric surfaces which will adsorb L1210 leukemia cells selectively more than that of healthy human leukocytes in order to develop new treatment options for people with leukemia. Chemically heterogeneous and micropatterned surfaces were formed on round glass slides by dip coating with accompanying phase-separation process where only commercial polymers were used. Surface properties were determined by using optical microscopy, 3D profilometry, SEM and measuring contact angles. Polymer, solvent/nonsolvent types, blend composition and temperature were found to be effective in controlling the dimensions of surface microislands. MTT tests were applied for cell viability performance of these surfaces. Polystyrene/polyethylene-polypropylene blend surfaces were found to show considerable positive selectivity to L1210 leukemia cells where L1210/healthy leukocytes adsorption ratio approached to 9-fold in vitro. Effects of wettability, surface free energy, microisland size geometry on the adsorption performances of L1210/leukocytes pairs are discussed.

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Section: Introductionmentioning

confidence: 99%

Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

Gengec¹,

Gulsuner²,

Erbil³

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…The corresponding fundamental research of cell-biomaterial interactions is a central fundamental topic in biomaterials and regenerative medicine. Many techniques such as surface patterning have been employed to reveal the underlying science [87,[89][90][91][92][93][94]. How to apply those principles into scaffolding, for instance, and how to control surface topography in the interior surfaces of a three-dimensional scaffold, remain as new challenging topics.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Poly(lactide- co -glycolide) porous scaffolds for tissue engineering and regenerative medicine

2012

Self Cite

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Porous scaffolds fabricated from biocompatible and biodegradable polymers play vital roles in tissue engineering and regenerative medicine. Among various scaffold matrix materials, poly(lactide-co-glycolide) (PLGA) is a very popular and an important biodegradable polyester owing to its tunable degradation rates, good mechanical properties and processibility, etc. This review highlights the progress on PLGA scaffolds. In the latest decade, some facile fabrication approaches at room temperature were put forward; more appropriate pore structures were designed and achieved; the mechanical properties were investigated both for dry and wet scaffolds; a long time biodegradation of the PLGA scaffold was observed and a three-stage model was established; even the effects of pore size and porosity on in vitro biodegradation were revealed; the PLGA scaffolds have also been implanted into animals, and some tissues have been regenerated in vivo after loading cells including stem cells.

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“…It has been found that smaller islands or beads made more endothelial cells to enter into apoptosis, whereas the cells on larger islands grew normally [82,83]. The abovementioned results have been recently reported in other cell lines such as fibroblasts, osteoblasts, and mesenchymal stem cells [84].…”

Section: Effect Of Properties Of Substratementioning

confidence: 80%

Probing the mechanosensitivity in cell adhesion and migration: Experiments and modeling

Huo

2013

Acta Mech Sin

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Cell adhesion and migration are basic physiological processes in living organisms. Cells can actively probe their mechanical micro-environment and respond to the external stimuli through cell adhesion. Cells need to move to the targeting place to perform function via cell migration. For adherent cells, cell migration is mediated by cell-matrix adhesion and cell-cell adhesion. Experimental approaches, especially at early stage of investigation, are indispensable to studies of cell mechanics when even qualitative behaviors of cell as well as fundamental factors in cell behaviors are unclear. Currently, there is increasingly accumulation of experimental data of measurement, thus a quantitative formulation of cell behaviors and the relationship among these fundamental factors are highly needed. This quantitative understanding should be crucial to tissue engineering and biomedical engineering when people want to accurately regulate or control cell behaviors from single cell level to tissue level. In this review, we will elaborate recent advances in the experimental and theoretical studies on cell adhesion and migration, with particular focuses laid on recent advances in experimental techniques and theoretical modeling, through which challenging problems in the cell mechanics are suggested.

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Critical areas of cell adhesion on micropatterned surfaces

Cited by 100 publications

References 74 publications

Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

Selective adsorption of L1210 leukemia cells/human leukocytes on micropatterned surfaces prepared from polystyrene/polypropylene-polyethylene blends

Poly(lactide- co -glycolide) porous scaffolds for tissue engineering and regenerative medicine

Probing the mechanosensitivity in cell adhesion and migration: Experiments and modeling

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