Critical Appraisal of the Clinical Practice Guidelines for the Management of Dyslipidaemias: Lipid Modification to Reduce Cardiovascular Risk: European Society of Cardiology (ESC) and European Atherosclerosis Society (ESC/EAS) 2019 Guidelines

Alhmoud, Eman; Barazi, Raja; Fahmi, Amr Mohamed; Abdu, Abdullah; Higazy, Alya; Hajj, Maguy Saffouh El

doi:10.1111/jphs.12371

Cited by 4 publications

(1 citation statement)

References 7 publications

(6 reference statements)

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“…The inverse association between plasma high-density lipoprotein and the risk of CVD is among the most consistent and reproducible associations in observational epidemiology. Higher plasma Lp(a) concentrations are associated with an increased risk of CVD, but it appears to be a much weaker risk factor for most people than LDL cholesterol [ 52 ]. Commonly, plasma cholesterol is used to calculate cardiovascular risk, whereas LDL is used to evaluate the achieving of target values according to the estimated cardiovascular risk.…”

Section: Resultsmentioning

confidence: 99%

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

et al. 2021

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Background The spread of false medical information on the web is rapidly accelerating. Establishing the credibility of web-based medical information has become a pressing necessity. Machine learning offers a solution that, when properly deployed, can be an effective tool in fighting medical misinformation on the web. Objective The aim of this study is to present a comprehensive framework for designing and curating machine learning training data sets for web-based medical information credibility assessment. We show how to construct the annotation process. Our main objective is to support researchers from the medical and computer science communities. We offer guidelines on the preparation of data sets for machine learning models that can fight medical misinformation. Methods We begin by providing the annotation protocol for medical experts involved in medical sentence credibility evaluation. The protocol is based on a qualitative study of our experimental data. To address the problem of insufficient initial labels, we propose a preprocessing pipeline for the batch of sentences to be assessed. It consists of representation learning, clustering, and reranking. We call this process active annotation. Results We collected more than 10,000 annotations of statements related to selected medical subjects (psychiatry, cholesterol, autism, antibiotics, vaccines, steroids, birth methods, and food allergy testing) for less than US $7000 by employing 9 highly qualified annotators (certified medical professionals), and we release this data set to the general public. We developed an active annotation framework for more efficient annotation of noncredible medical statements. The application of qualitative analysis resulted in a better annotation protocol for our future efforts in data set creation. Conclusions The results of the qualitative analysis support our claims of the efficacy of the presented method.

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Section: Resultsmentioning

confidence: 99%

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

et al. 2021

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Methodological quality and clinical recommendations of guidelines on the management of dyslipidaemias for cardiovascular disease risk reduction: a systematic review and an appraisal through AGREE II and AGREE REX tools

Deffert,

Vilela,

Cobre

et al. 2024

Family Practice

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Background Clinical practice guidelines (CPGs) are statements to assist practitioners and stakeholders in decisions about healthcare. Low methodological quality guidelines may prejudice decision-making and negatively affect clinical outcomes in non-communicable diseases, such as cardiovascular diseases worsted by poor lipid management. We appraised the quality of CPGs on dyslipidemia management and synthesized the most updated pharmacological recommendations. Methods A systematic review following international recommendations was performed. Searches to retrieve CPG on pharmacological treatments in adults with dyslipidaemia were conducted in PubMed, Scopus, and Trip databases. Eligible articles were assessed using AGREE II (methodological quality) and AGREE-REX (recommendation excellence) tools. Descriptive statistics were used to summarize data. The most updated guidelines (published after 2019) had their recommendations qualitatively synthesized in an exploratory analysis. Results Overall, 66 guidelines authored by professional societies (75%) and targeting clinicians as primary users were selected. The AGREE II domains Scope and Purpose (89%) and Clarity of Presentation (97%), and the AGREE-REX item Clinical Applicability (77.0%) obtained the highest values. Conversely, guidelines were methodologically poorly performed/documented (46%) and scarcely provided data on the implementability of practical recommendations (38%). Recommendations on pharmacological treatments are overall similar, with slight differences concerning the use of supplements and the availability of drugs. Conclusion High-quality dyslipidaemia CPG, especially outside North America and Europe, and strictly addressing evidence synthesis, appraisal, and recommendations are needed, especially to guide primary care decisions. CPG developers should consider stakeholders’ values and preferences and adapt existing statements to individual populations and healthcare systems to ensure successful implementation interventions.

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Chronic Brain Ischemia: From Risk Factors to Cerebrovascular Complications

Yusupov

Nurmatov

Абдыкалыкова

et al. 2021

BSP

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Chronic cerebral ischemia is a polyetiological, chronic progressive dysfunction of the brain caused by diffuse and / or small focal damage to the brain tissue in conditions of prolonged insufficiency of cerebral blood supply. The review reflects the current understanding of chronic cerebral ischemia. The main pathogenetic mechanisms of the onset of chronic cerebral ischemia in patients with arterial hypertension, atherosclerosis and smoking are outlined.

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Critical Appraisal of the Clinical Practice Guidelines for the Management of Dyslipidaemias: Lipid Modification to Reduce Cardiovascular Risk: European Society of Cardiology (ESC) and European Atherosclerosis Society (ESC/EAS) 2019 Guidelines

Cited by 4 publications

References 7 publications

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

Methodological quality and clinical recommendations of guidelines on the management of dyslipidaemias for cardiovascular disease risk reduction: a systematic review and an appraisal through AGREE II and AGREE REX tools

Chronic Brain Ischemia: From Risk Factors to Cerebrovascular Complications

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