Critical Analysis of Short-Latency Auditory Evoked Potentials Recording Techniques

Hashimoto, Isao

doi:10.1007/978-1-4684-9007-7_5

Cited by 4 publications

(2 citation statements)

References 128 publications

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“…Previous studies of wave I and wave V suggest that they comprise a very useful, robust response in humans (Boettcher, 2002), with the peaks being generated from different parts of the cochlea and brainstem auditory system. For instance, P1 (wave I for humans) is produced by the auditory nerve; while P4 (mice) and wave V (human) are generated from the lateral lemniscus/inferior colliculus (IC) of the brainstem (Hashimoto, 1989; Hashimoto et al, 1981; Møller & Janetta, 1982, 1983). With age, the degeneration of auditory brainstem neural circuitry contributes to the reduction in ABR peak responses.…”

Section: Discussionmentioning

confidence: 99%

Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss

et al. 2014

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The CBA/CaJ mouse strain's auditory function is normal during the early phases of life and gradually declines over its lifespan, much like human age-related hearing loss (ARHL), but on a mouse life cycle “time frame”. This pattern of ARHL is relatively similar to that of most humans: difficult to clinically diagnose at its onset, and currently not treatable medically. To address the challenge of early diagnosis, CBA mice were used for the present study to analyze the beginning stages and functional onset biomarkers of ARHL. The results from Auditory Brainstem Response (ABR) audiogram and Gap-in-noise (GIN) ABR tests were compared for two groups of mice of different ages, young adult and middle age. ABR peak components from the middle age group displayed minor changes in audibility, but had a significantly higher prolonged peak latency and decreased peak amplitude in response to temporal gaps in comparison to the young adult group. The results for the younger subjects revealed gap thresholds and recovery rates that were comparable to previous studies of auditory neural gap coding. Our findings suggest that age-linked degeneration of the peripheral and brainstem auditory system is already beginning in middle age, allowing for the possibility of preventative biomedical or hearing protection measures to be implemented as a possibility for attenuating further damage to the auditory system due to ARHL.

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Section: Discussionmentioning

confidence: 99%

Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss

et al. 2014

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“…Wave IV is likely to arise in the superior olivary complex (SOC) (Møller & Janetta, 1982;Møller, Jho, Yokoto, & Janetta, 1994). Wave V in the human is likely to be generated in the tracts of the lateral lemniscus, particularly those contralateral to the stimulated ear (Hashimoto, 1989;Hashimoto et al, 1981;Møller, 1999;Møller & Janetta, Figure 1. ABR waveforms from a young adult human (upper wave) and gerbil (lower wave).…”

Section: Characteristics Of the Abrmentioning

confidence: 99%

Presbyacusis and the Auditory Brainstem Response

Boettcher

2002

J Speech Lang Hear Res

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Age-related hearing loss (ARHL or presbyacusis) is an increasingly common form of sensorineural hearing loss (SNHL) as a result of changing demographics, and the auditory brainstem response (ABR) is a common experimental and clinical tool in audiology and neurology. Some of the changes that occur in the aging auditory system may significantly influence the interpretation of the ABR in comparison to the ABRs of younger adults. The approach of this review will be to integrate physiological and histopathological data from human and animal studies to provide a better understanding of the array of age-related changes in the ABR and to determine how age-related changes in the auditory system may influence how the ABR should be interpreted in presbyacusis. Data will be described in terms of thresholds, latencies, and amplitudes, as well as more complex auditory functions such as masking and temporal processing. Included in the review of data will be an attempt to differentiate between age-related effects that may strictly be due to threshold elevation from those that may be due to the aging process.

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Reversibility of brain-stem evoked potential abnormalities in abstinent chronic alcoholics: One year follow-up

Cadaveira

Corominas

Holguı́n

et al. 1994

Electroencephalography and Clinical Neurophysiology

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Brain-stem auditory evoked potentials (BAEPs) were studied in 34 chronic alcoholics who had been abstinent for 1 year, and in age- and sex-matched control subjects. The patients were examined 3 times, at 1 month, 5 months and 1 year after the start of the abstinence treatment. At 1 month of abstinence the alcoholics showed differences with respect to controls in the peak V latency (P < 0.01), and in the III-V (P < 0.01) and I-V (P < 0.01) intervals. After 1 year of abstinence a significant improvement in the V (P < 0.01), III-V (P < 0.01) and I-V (P < 0.01) parameters was recorded. The most notable development was in the 5-12 month period, with shortening in V latency (P < 0.01) and in the I-V interval (P < 0.01); in the first 5 months there was only shortening in the III-V interval (P < 0.01). This improvement was also indicated by a decrease in the number of patients with BAEP parameter abnormalities. The recovery of the functions impaired by chronic alcohol consumption after 1 year of abstinence was incomplete, although the tendency was towards normalization.

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Critical Analysis of Short-Latency Auditory Evoked Potentials Recording Techniques

Cited by 4 publications

References 128 publications

Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss

Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss

Presbyacusis and the Auditory Brainstem Response

Reversibility of brain-stem evoked potential abnormalities in abstinent chronic alcoholics: One year follow-up

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