Critical Analysis of Cancer Therapy using Nanomaterials

Juillerat‐Jeanneret, Lucienne

doi:10.1002/9783527610419.ntls0066

Cited by 6 publications

(3 citation statements)

References 156 publications

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“…The drugs are dissolved, entrapped, encapsulated, adsorbed, or chemically linked to the surface of the NPs. The polymer structure and the drug trapping method determine the drug characteristics and its release kinetics from the nanoparticles [ 228 ]. One example of nanoparticle drug delivery approach is the usage of nanoparticles coated choline derivative that is reported to be transported across brain-derived endothelial cells by the cation transporter system [ 229 ].…”

Section: Drug Delivery Approaches and Current Advances In Brain Tumentioning

confidence: 99%

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Bhowmik

Khan

Ghosh

2015

BioMed Research International

215

155

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Brain tumors are one of the most formidable diseases of mankind. They have only a fair to poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain tumor treatment is the presence of blood brain barrier (BBB). BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. Thus, along with the conventional techniques, successful modification of drug delivery and novel therapeutic strategies are needed to overcome this obstacle for treatment of brain tumors. In this review, we have elucidated some critical insights into the composition and function of BBB and along with it we have discussed the effective methods for delivery of drugs to the brain and therapeutic strategies overcoming the barrier.

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Section: Drug Delivery Approaches and Current Advances In Brain Tumentioning

confidence: 99%

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Bhowmik

Khan

Ghosh

2015

BioMed Research International

215

155

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“…Thus, by reducing particle sizes from micrometers to nanometers ( nanonization ), and thus, increasing surface area, one or more order(s) of magnitude increase in dissolution rate can be achieved [ 58 , 59 , 60 ]. Tumor vasculature is highly abnormal, proliferative, activated, and tortuous; it presents increased permeability and gaps, with pores between 350 and 800 nm in diameter, and a cutoff around 400 nm [ 61 ]. Thus preparation of nanoparticles to be 100–200 nm in diameter by any nanosizing technique gives a good predisposition for nanodrug penetration into a tumor body.…”

Section: Medicinal Use Of Arsenic Compoundsmentioning

confidence: 99%

Arsenic in Cancer Treatment: Challenges for Application of Realgar Nanoparticles (A Minireview)

Baláž

Sedlák

2010

Toxins

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While intensive efforts have been made for the treatment of cancer, this disease is still the second leading cause of death in many countries. Metastatic breast cancer, late-stage colon cancer, malignant melanoma, multiple myeloma, and other forms of cancer are still essentially incurable in most cases. Recent advances in genomic technologies have permitted the simultaneous evaluation of DNA sequence-based alterations together with copy number gains and losses. The requirement for a multi-targeting approach is the common theme that emerges from these studies. Therefore, the combination of new targeted biological and cytotoxic agents is currently under investigation in multimodal treatment regimens. Similarly, a combinational principle is applied in traditional Chinese medicine, as formulas consist of several types of medicinal herbs or minerals, in which one represents the principal component, and the others serve as adjuvant ones that assist the effects, or facilitate the delivery, of the principal component. In Western medicine, approximately 60 different arsenic preparations have been developed and used in pharmacological history. In traditional Chinese medicines, different forms of mineral arsenicals (orpiment—As2S3, realgar—As4S4, and arsenolite—arsenic trioxide, As2O3) are used, and realgar alone is included in 22 oral remedies that are recognized by the Chinese Pharmacopeia Committee (2005). It is known that a significant portion of some forms of mineral arsenicals is poorly absorbed into the body, and would be unavailable to cause systemic damage. This review primary focuses on the application of arsenic sulfide (realgar) for treatment of various forms of cancer in vitro and in vivo.

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“…Since then more than 40 nanoparticulate systems have been approved (Boulaiz et al 2011;Schütz et al 2013a;2013b), mainly in the field of cancer treatment and predominantly represented by liposomal and micellar forms of widely used but poorly bioavailable anti-cancer agents. A variety of chemotherapeutic NPs are presently under pre-clinical development, in clinical use, or under advanced clinical trials (Juillerat-Jeanneret, 2006;Schütz et al, 2013a;Schütz et al, 2013b) (Table 1).…”

Section: Introduction: Therapeutic Nanoparticles In Human Medicinementioning

confidence: 99%

Biological impact assessment of nanomaterial used in nanomedicine. Introduction to the NanoTEST project

et al. 2013

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Therapeutic nanoparticles (NPs) are used in nanomedicine as drug carriers or imaging agents, providing increased selectivity/specificity for diseased tissues. The first NPs in nanomedicine were developed for increasing the efficacy of known drugs displaying dose-limiting toxicity and poor bioavailability and for enhancing disease detection. Nanotechnologies have gained much interest owing to their huge potential for applications in industry and medicine. It is necessary to ensure and control the biocompatibility of the components of therapeutic NPs to guarantee that intrinsic toxicity does not overtake the benefits. In addition to monitoring their toxicity in vitro, in vivo and in silico, it is also necessary to understand their distribution in the human body, their biodegradation and excretion routes and dispersion in the environment. Therefore, a deep understanding of their interactions with living tissues and of their possible effects in the human (and animal) body is required for the safe use of nanoparticulate formulations. Obtaining this information was the main aim of the NanoTEST project, and the goals of the reports collected together in this special issue are to summarise the observations and results obtained by the participating research teams and to provide methodological tools for evaluating the biological impact of NPs.

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Critical Analysis of Cancer Therapy using Nanomaterials

Abstract: The sections in this article are Introduction Anticancer Therapies Characteristics of Nanoparticles for Cancer Therapy Nanovectors Biological Issues Nanoparticle Targeting: Passive or Active Nanovectors in Biomedical Applications: Drug Delivery Systems ( … Show more

Cited by 6 publications

References 156 publications

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Arsenic in Cancer Treatment: Challenges for Application of Realgar Nanoparticles (A Minireview)

Biological impact assessment of nanomaterial used in nanomedicine. Introduction to the NanoTEST project

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