Critical analysis of algino-carbopol multiparticulate system for the improvement of flowability, compressibility and tableting properties of a poor flow drug

Khandai, Madhusmruti; Chakraborty, Santanu; Ghosh, Ashoke Kumar

doi:10.1016/j.powtec.2013.11.026

Cited by 8 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For C 3 N 4 , the peak at 2831 cm −1 corresponded to the stretching vibration of the aromatic C-N group. Also, the presence of heptazine rings was ascertained from the appearance of peaks at 781 cm −1 and 611 cm −1 [ 48 , 49 ]. Bi=O=Bi vibration in the nanocomposite hydrogel was observed at 848 cm −1 as compared to 883 cm −1 in the case of pristine BiOI in ( Figure 1 b, part (i)).…”

Section: Resultsmentioning

confidence: 99%

Gum Acacia-Crosslinked-Poly(Acrylamide) Hydrogel Supported C3N4/BiOI Heterostructure for Remediation of Noxious Crystal Violet Dye

et al. 2022

View full text Add to dashboard Cite

Herein, we report the designing of a C3N4/BiOI heterostructure that is supported on gum acacia-crosslinked-poly(acrylamide) hydrogel to fabricate a novel nanocomposite hydrogel. The potential application of the obtained nanocomposite hydrogel to remediate crystal violet dye (CVD) in an aqueous solution was explored. The structural and functional analysis of the nanocomposite hydrogel was performed by FTIR (Fourier transform infrared spectroscopy), X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The different reaction parameters, such as CVD concentration, nanocomposite hydrogel dosage, and working pH, were optimized. The C3N4/BiOI heterostructure of the nanocomposite hydrogel depicts Z-scheme as the potential photocatalytic mechanism for the photodegradation of CVD. The degradation of CVD was also specified in terms of COD and HR-MS analysis was carried to demonstrate the major degradation pathways.

show abstract

Section: Resultsmentioning

confidence: 99%

Gum Acacia-Crosslinked-Poly(Acrylamide) Hydrogel Supported C3N4/BiOI Heterostructure for Remediation of Noxious Crystal Violet Dye

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Powder compressibility is commonly used as a flowability indicator and is often expressed using the Hausner ratio, by means of aerated/tapped bulk density ratio and is appropriate to estimate cohesion in powders. In addition, the Carr index is other compressibility indicator to evaluate powder flow properties (Thalberg et al, 2004;Cavalvante-Alves et al, 2008;Khandai et al, 2014). Nowadays, the study of food powder microstructure is relevant and has grown in parallel with the development of microscopy and image processing techniques (Wang, 2006;Pérez-Alonso et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Physical-chemical properties and microstructural characterization of traditional mexican chili (Capsicum annuum L.) powders

Perea-Flores

Morón

Amor

et al. 2021

View full text Add to dashboard Cite

Objective: Evaluate the physical-chemical properties and characterize the microstructure of four varieties of traditional Mexican chili (Capsicum annuum L.) powders: “Arbol”, “Guajillo”, “Piquin” and “Mole ranchero” (Ancho chili). Design/methodology/approach: Physical-chemical properties of chili powders were evaluated by means of moisture content, particle size, aerated and tapped bulk density, Carr index, Hausner ratio, angle of repose (flow properties), capsaicin, and carotenoids content. Microstructure of samples was characterized by Confocal Laser Scanning Microscopy and Scanning Electron Microscopy. ANOVA analysis and Tukey test were performed to evaluate the significant statistical difference between samples at 95% of confidence level. Results: “Arbol”, “Guajillo”, “Piquin” and “Mole Ranchero” chili powders presented a cohesive behavior respect to its flow properties related to aerated and tapped bulk density, angle of repose, Carr Index, and Hausner ratio values under moisture content between 6.59-14.48 gH2O/100g d.s. “Arbol” and “Piquin” chili powders presented the higher capsaicin content, while “Guajillo” and “Mole ranchero” showed the higher carotenoids content. FTIR spectra confirmed the presence of secondary amide, phenolic groups, alkanes, and aliphatic chains that belong to capsaicin structure at specific absorption bands. Microstructure of chili powders presented particles with surface imperfections as cracks and dents, and smooth surface that influence physical-chemical and flowability properties. Limitations on study/implications: Hight moisture content affect the physical-chemical properties, flowability and microstructure of traditional Mexican chili powders. Findings/conclusions: Moisture content between 6.59 and 14.48 gH2O/100g d.s. influences the physical-chemical properties, flowability and microstructure of traditional Mexican chili powders. To improve physical-chemical properties and flowability behavior of chili powders is required that moisture content be lower than 6.59 H2O/100g d.s.

show abstract

“…Tablets and capsules are the most frequently used dosage form because of the manufacturing simplicity, administration convenience with accurate dosing, and high stability [4]. The specific material properties such as flowability play a critical role in tableting and capsule preparation [5]. DVX is a highly hygroscopic and waxy powder unsuitable for tableting and capsule filling procedures [6].…”

Section: Introductionmentioning

confidence: 99%

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

et al. 2017

View full text Add to dashboard Cite

show abstract

Critical analysis of algino-carbopol multiparticulate system for the improvement of flowability, compressibility and tableting properties of a poor flow drug

Cited by 8 publications

References 10 publications

Gum Acacia-Crosslinked-Poly(Acrylamide) Hydrogel Supported C3N4/BiOI Heterostructure for Remediation of Noxious Crystal Violet Dye

Gum Acacia-Crosslinked-Poly(Acrylamide) Hydrogel Supported C3N4/BiOI Heterostructure for Remediation of Noxious Crystal Violet Dye

Physical-chemical properties and microstructural characterization of traditional mexican chili (Capsicum annuum L.) powders

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

Contact Info

Product

Resources

About