Criterion Validity and Responsiveness of the Steep Ramp Test to Evaluate Aerobic Capacity in Survivors of Cancer Participating in a Supervised Exercise Rehabilitation Program

Weemaes, Anouk T R; Beelen, Milou; Bongers, Bart C.; Weijenberg, Matty P.; Lenssen, Antoine F.

doi:10.1016/j.apmr.2021.04.016

Cited by 21 publications

(23 citation statements)

References 25 publications

(33 reference statements)

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“…Aerobic fitness was estimated using the steep ramp test (SRT), a short‐time maximal cycle ergometer exercise test (Lode Corival Rehab, Lode BV), 14 and expressed as the attained work rate at peak exercise (WR peak ) adjusted for body mass (SRT WR peak in W/kg). After 2 min of unloaded cycling, the work rate was increased by 10 W/10 s in a ramp‐like manner until voluntary exhaustion.…”

Section: Methodsmentioning

confidence: 99%

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Aerobic fitness and muscle density play a vital role in postoperative complications in colorectal cancer surgery

Cuijpers

Bongers

Heldens

et al. 2022

Journal of Surgical Oncology

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Background and Objectives To assess the association of preoperative aerobic fitness and body composition variables with a patient's resilience to the development and impact of postoperative complications after elective colorectal cancer (CRC) surgery. Methods Preoperative aerobic fitness was assessed by steep ramp test performance. Preoperative body composition was assessed by muscle mass and density determined from preoperative computed tomography scan analysis at the L3‐level. Complication development and severity was graded according to Clavien‐Dindo. Complication impact was assessed by the time to recovery of physical functioning after complications. Multivariable logistic regression analyses adjusted for age, sex, comorbidities and tumour location was performed. Results Of 238 included patients, 96 (40.3%) developed postoperative complications. Better preoperative aerobic fitness decreased the likelihood to develop complications, independent of muscle mass (odds ratio [OR]: 0.55, 95% confidence interval [CI]: 0.35−0.85) or muscle density (OR: 0.57, 95% CI: 0.36−0.89). A prolonged time to recovery following complications was associated with lower preoperative muscle density (OR: 4.14, 95% CI: 1.28−13.41), independent of aerobic fitness. Conclusions Lower aerobic fitness increases the risk of complication development, while low muscle density seems associated with a prolonged recovery from complications. Aerobic fitness and muscle density could be valuable additives to preoperative risk assessment.

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Section: Methodsmentioning

confidence: 99%

“…Aerobic fitness was estimated using the steep ramp test (SRT), a short-time maximal cycle ergometer exercise test (Lode Corival Rehab, Lode BV), 14 and expressed as the attained work rate at peak exercise (WR peak ) adjusted for body mass (SRT WR peak in W/kg).…”

Section: Preoperative Aerobic Fitness Assessmentmentioning

confidence: 99%

Aerobic fitness and muscle density play a vital role in postoperative complications in colorectal cancer surgery

Cuijpers

Bongers

Heldens

et al. 2022

Journal of Surgical Oncology

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“…A cardiopulmonary exercise test (CPET) was performed as part of usual-care, to screen for cardiopulmonary contraindications to exercise and to determine aerobic capacity. The CPET was conducted on a cycle ergometer (Lode Corival, Lode BV) as described previously [ 17 ]. After a warm-up phase, the work rate (WR) increased gradually according to an incremental ramp protocol, which was determined based on the participants’ self-reported physical activity level, aiming at a test duration of 8–12 min.…”

Section: Methodsmentioning

confidence: 99%

Exercise training as part of multidisciplinary rehabilitation in cancer survivors: an observational study on changes in physical performance and patient-reported outcomes

Weemaes

Weijenberg

Lenssen

et al. 2022

Support Care Cancer

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Purpose To describe changes in physical performance and patient-reported outcomes in cancer survivors who participated in an exercise program as part of usual-care multidisciplinary rehabilitation and the influence of training adaptations during the coronavirus-19 (COVID-19) pandemic. Methods In an observational cohort study, cancer survivors underwent usual-care multidisciplinary rehabilitation including a 10-week exercise program. During the COVID-19 pandemic, the exercise program was adapted with reduced training time and frequency. Mean changes and 95% confidence intervals in physical performance (peak oxygen uptake (VO2peak), peak work rate during a steep ramp test (SRT-WRpeak), 6-min walking distance, muscle strength) and patient-reported outcomes (health-related quality of life, fatigue, anxiety, and depression) were assessed between the start and the end of the exercise program. Linear regression analysis, adjusting for baseline levels of outcomes, was used to investigate differences in changes in outcomes between participants who underwent the original and the adapted program. Results All outcomes statistically significantly improved over time, regardless of adaptations in the exercise program. VO2peak increased with 9.6% and 7.7% in the original and adapted program, respectively. Significant smaller improvements were observed in SRT-WRpeak (− 3.9%) and upper body muscle strength (− 10.8%) after participation in the adapted compared to the original program. No significant between-group differences were observed for other outcomes. Conclusion Physical performance and patient-reported outcomes statistically and clinically significantly improved in cancer survivors who participated in an exercise program as part of usual-care multidisciplinary rehabilitation. Improvements of performance outcomes were smaller since the training adaptations, though only significant for SRT-WRpeak and upper body strength.

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“…A more detailed description of both tests is provided in the protocol papers of the original studies (10,13). The outcomes of the cardiopulmonary exercise test (V Ȯ2peak ) and Steep Ramp Test (MSEC) have been shown to be highly correlated (ranging from 0.73 to 0.86) in healthy and patient populations including cancer survivors (15)(16)(17)(18)(19)(20).…”

Section: Methodsmentioning

confidence: 99%

Physical Fitness and Chemotherapy Tolerance in Patients with Early-Stage Breast Cancer

Groen

Naaktgeboren

Harten

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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Criterion Validity and Responsiveness of the Steep Ramp Test to Evaluate Aerobic Capacity in Survivors of Cancer Participating in a Supervised Exercise Rehabilitation Program

Abstract: Criterion validity and responsiveness of the steep ramp test to evaluate aerobic capacity in cancer survivors participating in a supervised exercise rehabilitation program,

Cited by 21 publications

References 25 publications

Aerobic fitness and muscle density play a vital role in postoperative complications in colorectal cancer surgery

Aerobic fitness and muscle density play a vital role in postoperative complications in colorectal cancer surgery

Exercise training as part of multidisciplinary rehabilitation in cancer survivors: an observational study on changes in physical performance and patient-reported outcomes

Physical Fitness and Chemotherapy Tolerance in Patients with Early-Stage Breast Cancer

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