Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma

Takei, Yoji; Fukushiro, Shinji; Ab, Ackerman

doi:10.1097/00000372-198506000-00002

Cited by 61 publications

(38 citation statements)

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“…Original studies and other reports have suggested that DTE is a solitary benign tumor that appears most frequently on the face of young women. 1,3,4 In our current study, we sought to further define the clinical characteristics and histologic behavior of DTE. We discuss the presentation and course of these lesions, and suggest modes for definitive management of these tumors.…”

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confidence: 99%

Desmoplastic trichoepithelioma

Mamelak

Goldberg

Katz

et al. 2010

Journal of the American Academy of Dermatology

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confidence: 99%

Desmoplastic trichoepithelioma

Mamelak

Goldberg

Katz

et al. 2010

Journal of the American Academy of Dermatology

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“…Literature is fully provided with many histological criteria in the differential diagnosis between both entities [16][17][18][19][20]. Nevertheless, the subject is far from being simple, taking into account the number of immunohistochemical studies [1][2][3][4][5][6][7][8][9][10][11], studies in molecular pathology [13], in immunofluorescence [21], or in ultrastructural pathology [12] that have focussed their attention on these different techniques for distinguishing both tumours from each other.…”

Section: Discussionmentioning

confidence: 99%

Advanced differentiation in trichoepithelioma and basal cell carcinoma investigated by immunohistochemistry against neurofilaments.

Fernández-Flores

2009

Folia Histochem Cytobiol.

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Basal cell carcinoma (BCC) and trichoepithelioma (TE) are sometimes diagnostic challenges for the pathologist in terms of their differential diagnosis. Although literature is quite rich in information about histologic and immunohistochemical clues to distinguish the differences between both, no single finding must be completely reliable. Moreover, some consider that TE is a better differentiated follicular tumour, while BCC represents a less developed stage in differentiation. For instance, the latter opinion is supported by the evidence of follicular papillae in TE. The formation of a perifollicular nerve plexus happens later than the formation of the follicular papillae in the development of a normal follicle. The study of the presence of the perifollicular nerve plexus in both tumours which could then provide us with evidence on the stage of differentiation of both tumours. 5 cases of TE and 10 cases of BCC were randomly selected from our archives and an immunohistochemical study for neurofilaments was performed in all the cases. We found a peritumoural nerve plexus in all the cases (TEs and BCCs). Since this plexus is a late sign of differentiation and since both types of neoplasias share it, we conclude that TE and BCC are both terminally differentiated neoplasms. The ability of BCC to infiltrate would have more to do with the acquisition by the tumour of such a property, rather than with a stage of indifferentiation.

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“…However, differentiating DTE from BCC and MAC remains challenging. Takei et al (17) discovered that the majority of clinically diagnosed DTE cases were actually BCC. Other lesions in their series were sebaceous hyperplasias, hamartoma, TE, melanocystic nevi and keratoses.…”

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confidence: 99%

“…Several attempts have been made to overcome those diagnostic challenges in ultrastructural pathology (14), molecular pathology (18), immunofluorescence (19) and immunohistochemical (17,(20)(21)(22)(23) studies. Immunohistochemical markers that have been proposed as criteria for the diagnosis and differentiation between DTE and MBCC are CK20 (for Merkel cells), p53, p75, CD10, CD34, PHLDA, AR, Ki-67 and Bcl-2.…”

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confidence: 99%

“…Costache et al (18) investigated several immunohistological markers, namely CK20, AR, Ki-67, CD34, p53, Bcl-2 and CD10. The study attempted to re-evaluate the histomorphological and immunohistochemical criteria previously proposed by Takei et al (17), which were available for the differentiation of DTE from MBCC, in order to figure out which of the criteria are the most reliable for a definitive diagnosis. The study found that CK20 and AR are the most reliable immunohistochemical markers for the differentiation between DTE and MBCC, supporting the data of previous studies by Abesamis-Cubillan et al (22) and Izikson et al (23).…”

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confidence: 99%

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Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature

et al. 2015

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Abstract. Desmoplastic trichoepithelioma (DTE) is a rare benign adnexal tumor with the characteristic features of asymptomatic, solitary, annular, indurated and centrally depressed papules or plaques, most commonly occurring in younger individuals on the face. Microscopically and clinically, DTE may be difficult to distinguish from other cutaneous adnexal neoplasms, particularly syringoma, cutaneous metastatic breast cancer, morpheaform basal cell carcinoma and microcystic adnexal carcinoma. The present study reports three cases of DTE. The first case was of a 45-year-old male with an asymptomatic flesh-colored plaque below the right edge of the outer canthus that had been present for seven years. The second case was of a 23-year-old female with an asymptomatic skin lesion on the right cheek that had slowly and progressively increased in size. The third case was of a 26-year-old female who presented with a hard yellowish-white plaque, which gradually grew and formed a rectangular, 3x4-cm patch, on the tip of the left brow. This plaque was present for three years without evident cause or subjective symptoms. In all three cases, the routine systemic examinations and laboratory findings were normal. Histopathological and immunohistochemical findings from incisional biopsies of the lesions were consistent with a diagnosis of DTE. DTE treatment methods and immunohistochemical markers were analyzed by reviewing clinical pathological aspects in order to avoid a misdiagnosis and to provide the best available treatment approach for DTE.

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Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma

Cited by 61 publications

References 0 publications

Desmoplastic trichoepithelioma

Desmoplastic trichoepithelioma

Advanced differentiation in trichoepithelioma and basal cell carcinoma investigated by immunohistochemistry against neurofilaments.

Desmoplastic trichoepithelioma: A clinicopathological study of three cases and a review of the literature

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